Role of essential fatty acids: dangers in the US Department of Agriculture dietary recommendations (“pyramid”) and in low-fat diets

1994 ◽  
Vol 60 (6) ◽  
pp. 973-974 ◽  
Author(s):  
E N Siguel ◽  
R H Lerman
2001 ◽  
Vol 73 (4) ◽  
pp. 685-744 ◽  
Author(s):  
J. L. Beare-Rogers ◽  
A. Dieffenbacher ◽  
J. V. Holm

The intertwining of lipid nutrition with many other disciplines makes contributions from different directions imperative. Chemistry, biochemistry, physiology, food science and technology, industrial processing, and consumer acceptance provide concepts and terms used in lipid nutrition. This document is the product of a working group comprising members of the Committee on the Biological Role of Fatty Acids in Human Nutrition of the International Union of Nutritional Sciences and of the Commission on Oils, Fats, and Derivatives of the International Union of Pure and Applied Chemistry. Shorthand formulas and systematic and trivial names of some biologically important fatty acids are given in Table 1 (saturated fatty acids), Table 2 (monoenoic fatty acids), and Table 3 (polyenoic fatty acids).Fatty acid compositions of foods have been based on the data of the USDA reference that means official grade standards for agriculture of the U.S. Department of Agriculture. Because foods may show large variations in their composition the figures in the annexed tables serve as guidelines only, except those of the Codex alimentarius (Tables 4 and 5), where accepted ranges of the figures are reported. Further, as these standards are in constant revision the reader may contact directly the USDA Agriculture Marketing Service for the last editions of these standards. It is evident that the explanation of the referred terms is a compromise between technological and scientific correctness and the readers' lack of interest in many of the details. But, sometimes a more exhaustive explanation is necessary. Further information then may be found in cross references, although they have been reduced to those of utmost necessity. Terms in the text where cross references are available are printed in boldfaced type. As research and science are progressing and knowledge is increasing, consequently, views on certain nutritional aspects are constantly changing, e.g., the role of essential fatty acids in human nutrition. Therefore, such a work will never be complete, and readers are invited to send their comments and observations to the authors for incorporation into a next edition.


Lipids ◽  
1991 ◽  
Vol 26 (1) ◽  
pp. 37-45 ◽  
Author(s):  
P. E. Wainwright ◽  
Y. S. Huang ◽  
B. Bulman-Fleming ◽  
D. E. Mills ◽  
P. Redden ◽  
...  

1986 ◽  
Vol 6 (8) ◽  
pp. 931-955 ◽  
Author(s):  
Olukemi Olubajo ◽  
Mary W. Marshall ◽  
Joseph T. Judd ◽  
James T. Adkins

1993 ◽  
Vol 265 (2) ◽  
pp. R414-R419 ◽  
Author(s):  
T. Xia ◽  
N. Mostafa ◽  
B. G. Bhat ◽  
G. L. Florant ◽  
R. A. Coleman

In the suckling rat, chick embryo, and hibernating marmot, fatty acids provide the major source of energy, and despite the high rate of hepatic beta-oxidation, these animals selectively retain long-chain polyunsaturated derivatives of C18:2n-6 and C18:3n-3. To determine whether the hepatic microsomal activity monoacylglycerol acyltransferase (MGAT) (EC 2.3.1.22) could provide a mechanism to selectively acylate monoacylglycerols that contain essential fatty acids, we tested the ability of MGAT activity from each of the three species to acylate sn-2-monoC18:1-, sn-2-monoC18:2-, sn-2-monoC18:3-, and sn-2-monoC20:4-glycerols. Hepatic MGAT activity acylated sn-2-monoC18:3-glycerol and sn-2-monoC18:2-glycerol in preference to sn-2-monoC18:1-glycerol in each of the three different lipolytic animals. MGAT's acyl group specificity could not be explained by invoking differences in membrane fluidity because the apparent affinity for sn-2-monoC20:4-glycerol was not increased. Further, sn-2-monoC18:3-glycerol remained a preferred substrate under assay conditions when both the C18:3 and C18:1 species were present in equal amounts. As would be predicted in the presence of high activity of a selective MGAT, the hepatic glycerolipids from neonatal rats showed increases in dienoic, trienoic, and C22:6 fatty acids and relative decreases in monoenoic, saturated, and C20:4 fatty acids. We hypothesize that, during lipolysis, the reacylation of sn-2-monoacylglycerols by MGAT may provide a mechanism by which essential fatty acids are retained within specific tissues.


2007 ◽  
Vol 7 ◽  
pp. 1440-1462 ◽  
Author(s):  
Gerhard Bannenberg ◽  
Makoto Arita ◽  
Charles N. Serhan

Controlled resolution or the physiologic resolution of a well-orchestrated inflammatory response at the tissue level is essential to return to homeostasis. A comprehensive understanding of the cellular and molecular events that control the termination of acute inflammation is needed in molecular terms given the widely held view that aberrant inflammation underlies many common diseases. This review focuses on recent advances in the understanding of the role of arachidonic acid and ω-3 polyunsaturated fatty acids (PUFA)–derived lipid mediators in regulating the resolution of inflammation. Using a functional lipidomic approach employing LC-MS-MS–based informatics, recent studies, reviewed herein, uncovered new families of local-acting chemical mediators actively biosynthesized during the resolution phase from the essential fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). These new families of local chemical mediators are generated endogenously in exudates collected during the resolution phase, and were coined resolvins and protectins because specific members of these novel chemical families control both the duration and magnitude of inflammation in animal models of complex diseases. Recent advances on the biosynthesis, receptors, and actions of these novel anti-inflammatory and proresolving lipid mediators are reviewed with the aim to bring to attention the important role of specific lipid mediators as endogenous agonists in inflammation resolution.


BioScience ◽  
2019 ◽  
Vol 70 (1) ◽  
pp. 90-96 ◽  
Author(s):  
David E Naugle ◽  
Brady W Allred ◽  
Matthew O Jones ◽  
Dirac Twidwell ◽  
Jeremy D Maestas

Abstract Conservationists are increasingly convinced that coproduction of science enhances its utility in policy, decision-making, and practice. Concomitant is a renewed reliance on privately owned working lands to sustain nature and people. We propose a coupling of these emerging trends as a better recipe for conservation. To illustrate this, we present five elements of coproduction, contrast how they differ from traditional approaches, and describe the role of scientists in successful partnerships. Readers will find coproduction more demanding than the loading dock approach to science delivery but will also find greater rewards, relevance, and impact. Because coproduction is novel and examples of it are rare, we draw on our roles as scientists within the US Department of Agriculture–led Sage Grouse Initiative, North America's largest effort to conserve the sagebrush ecosystem. As coproduction and working lands evolve, traditional approaches will be replaced in order to more holistically meet the needs of nature and people.


1961 ◽  
Vol 38 (6) ◽  
pp. 297-301 ◽  
Author(s):  
G. A. Dhopeshwarkar ◽  
James F. Mead

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