alpha-Linolenic acid- and docosahexaenoic acid-enriched eggs from hens fed flaxseed: influence on blood lipids and platelet phospholipid fatty acids in humans

1995 ◽  
Vol 62 (1) ◽  
pp. 81-86 ◽  
Author(s):  
L K Ferrier ◽  
L J Caston ◽  
S Leeson ◽  
J Squires ◽  
B J Weaver ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Docosahexaenoic Acid ◽  
Linolenic Acid ◽  
Blood Lipids ◽  
Phospholipid Fatty Acids ◽  
Platelet Phospholipid ◽  
Alpha Linolenic Acid

scholarly journals Polyunsaturated fatty acids and risk of Alzheimer’s disease: a Mendelian randomization study

2019 ◽  
Vol 59 (4) ◽  
pp. 1763-1766 ◽  
Author(s):  
Yasutake Tomata ◽  
Susanna C. Larsson ◽  
Sara Hägg
Keyword(s):  
Fatty Acids ◽  
Arachidonic Acid ◽  
Linoleic Acid ◽  
Docosahexaenoic Acid ◽  
Polyunsaturated Fatty Acids ◽  
Eicosapentaenoic Acid ◽  
Linolenic Acid ◽  
Mendelian Randomization ◽  
Docosapentaenoic Acid ◽  
Alpha Linolenic Acid

Abstract Purpose Observational studies have suggested that polyunsaturated fatty acids (PUFAs) may decrease Alzheimer’s disease (AD) risk. In the present study, we examined this hypothesis using a Mendelian randomization analysis. Methods We used summary statistics data for single-nucleotide polymorphisms associated with plasma levels of n-6 PUFAs (linoleic acid, arachidonic acid) and n-3 PUFAs (alpha-linolenic acid, eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid), and the corresponding data for AD from a genome-wide association meta-analysis of 63,926 individuals (21,982 diagnosed AD cases, 41,944 controls). Results None of the genetically predicted PUFAs was significantly associated with AD risk; odds ratios (95% confidence interval) per 1 SD increase in PUFA levels were 0.98 (0.93, 1.03) for linoleic acid, 1.01 (0.98, 1.05) for arachidonic acid, 0.96 (0.88, 1.06) for alpha-linolenic acid, 1.03 (0.93, 1.13) for eicosapentaenoic acid, 1.03 (0.97, 1.09) for docosapentaenoic acid, and 1.01 (0.81, 1.25) for docosahexaenoic acid. Conclusions This study did not support the hypothesis that PUFAs decrease AD risk.

scholarly journals Dietary Alpha-Linolenic Acid Supports High Retinal DHA Levels

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 301
Author(s):  
Andrew J. Sinclair ◽  
Xiao-Fei Guo ◽  
Lavinia Abedin
Keyword(s):  
Fatty Acids ◽  
Linoleic Acid ◽  
Docosahexaenoic Acid ◽  
Linolenic Acid ◽  
Guinea Pigs ◽  
Alpha Linolenic Acid ◽  
Linear Fashion ◽  
Optimal Function ◽  
Feeding Diets ◽  
Diet Fatty Acids

The retina requires docosahexaenoic acid (DHA) for optimal function. Alpha-linolenic acid (ALA) and DHA are dietary sources of retinal DHA. This research investigated optimizing retinal DHA using dietary ALA. Previous research identified 19% DHA in retinal phospholipids was associated with optimal retinal function in guinea pigs. Pregnant guinea pigs were fed dietary ALA from 2.8% to 17.3% of diet fatty acids, at a constant level of linoleic acid (LA) of 18% for the last one third of gestation and retinal DHA levels were assessed in 3-week-old offspring maintained on the same diets as their mothers. Retinal DHA increased in a linear fashion with the maximum on the diet with LA:ALA of 1:1. Feeding diets with LA:ALA of 1:1 during pregnancy and assessing retinal DHA in 3-week-old offspring was associated with optimized retinal DHA levels. We speculate that the current intakes of ALA in human diets, especially in relation to LA intakes, are inadequate to support high DHA levels in the retina.

scholarly journals Quantitative Determination of Fatty Acids in Marine Fish and Shellfish from Warm Water of Straits of Malacca for Nutraceutical Purposes

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Nurnadia Abd Aziz ◽  
Azrina Azlan ◽  
Amin Ismail ◽  
Suryati Mohd Alinafiah ◽  
Muhammad Rizal Razman
Keyword(s):  
Fatty Acids ◽  
Docosahexaenoic Acid ◽  
Polyunsaturated Fatty Acids ◽  
Eicosapentaenoic Acid ◽  
Linolenic Acid ◽  
Marine Fish ◽  
Saturated Fatty Acids ◽  
Alpha Linolenic Acid ◽  
Straits Of Malacca ◽  
Fish And Shellfish

This study was conducted to quantitatively determine the fatty acid contents of 20 species of marine fish and four species of shellfish from Straits of Malacca. Most samples contained fairly high amounts of polyunsaturated fatty acids (PUFAs), especially alpha-linolenic acid (ALA, C18:3 n3), eicosapentaenoic acid (EPA, C20:5 n3), and docosahexaenoic acid (DHA, C22:6 n3). Longtail shad, yellowstripe scad, and moonfish contained significantly higher (P<0.05) amounts of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and alpha-linolenic acid (ALA), respectively. Meanwhile, fringescale sardinella, malabar red snapper, black pomfret, Japanese threadfin bream, giant seaperch, and sixbar grouper showed considerably high content (537.2–944.1 mg/100g wet sample) of desirable omega-3 fatty acids. The polyunsaturated-fatty-acids/saturated-fatty-acids (P/S) ratios for most samples were higher than that of Menhaden oil (P/S=0.58), a recommended PUFA supplement which may help to lower blood pressure. Yellowstripe scad (highest DHA,ω-3/ω-6=6.4,P/S=1.7), moonfish (highest ALA,ω-3/ω-6=1.9,P/S=1.0), and longtail shad (highest EPA,ω-3/ω-6=0.8,P/S=0.4) were the samples with an outstandingly desirable overall composition of fatty acids. Overall, the marine fish and shellfish from the area contained good composition of fatty acids which offer health benefits and may be used for nutraceutical purposes in the future.

scholarly journals Effects of dietary intake of gamma-linolenic acid on blood lipids and phospholipid fatty acids in healthy human subjects.

1990 ◽  
Vol 8 (1) ◽  
pp. 75-84 ◽  
Author(s):  
Jean-Louis RICHARD ◽  
Claude MARTIN ◽  
Michel MAILLE ◽  
François MENDY ◽  
Bernadette DELPLANQUE ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Dietary Intake ◽  
Linolenic Acid ◽  
Blood Lipids ◽  
Human Subjects ◽  
Phospholipid Fatty Acids ◽  
Gamma Linolenic Acid ◽  
Healthy Human ◽  
Healthy Human Subjects
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