scholarly journals Do low doses of folic acid result in maximum lowering of homocysteine?

2005 ◽  
Vol 82 (4) ◽  
pp. 717-718 ◽  
Author(s):  
Lynn B Bailey
Keyword(s):  
Folic Acid ◽  
Low Doses

scholarly journals A dual-isotope-labeling method of studying the bioavailability of hexaglutamyl folic acid relative to that of monoglutamyl folic acid in humans by using multiple orally administered low doses

2006 ◽  
Vol 84 (5) ◽  
pp. 1128-1133 ◽  
Author(s):  
Alida Melse-Boonstra ◽  
Petra Verhoef ◽  
Clive E West ◽  
Johannes A van Rhijn ◽  
Richard B van Breemen ◽  
...  
Keyword(s):  
Folic Acid ◽  
Isotope Labeling ◽  
Low Doses ◽  
Dual Isotope ◽  
Labeling Method

Low doses of folic acid can reduce hyperhomocysteinemia-induced glomerular injury in spontaneously hypertensive rats

2020 ◽  
Vol 43 (11) ◽  
pp. 1182-1191 ◽  
Author(s):  
Ning Gao ◽  
Yuzhen Zhang ◽  
Lei Lei ◽  
Li Li ◽  
Ping Cao ◽  
...  
Keyword(s):  
Folic Acid ◽  
Spontaneously Hypertensive Rats ◽  
Low Doses ◽  
Glomerular Injury ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

The chemotherapy of Plasmodium berghei. I. Resistance to drugs

Parasitology ◽  
1953 ◽  
Vol 43 (3-4) ◽  
pp. 246-252 ◽  
Author(s):  
June P. Thurston
Keyword(s):  
Methylene Blue ◽  
Folic Acid ◽  
Plasmodium Berghei ◽  
Resistant Strain ◽  
Active Metabolite ◽  
Parent Strain ◽  
Low Doses ◽  
Aminobenzoic Acid ◽  
Acute Infections

1. Strains of P. berghei resistant to sulphadiazine, pyrimethamine, and methylene blue were produced by treating acute infections with low doses of drug.2. The strain resistant to methylene blue was sensitive to pamaquin, mepacrine, sulphadiazine, proguanil, pyrimethamine, and 2 : 4-diamino-6 : 7-camphano-pteridine.3. The pyrimethamine-resistant strain was cross-resistant to proguanil and its active metabolite CPT, 2 : 4-diamino-6 : 7-camphanopteridine, 2 : 4-diamino-6 : 7-(l′-ethylindolo)-pteridine, and 2 : 4-diamino-5-p-chlorophenylpyrimidine.4. The sulphadiazine-resistant strain was cross-resistant to pyrimethamine, sulphanilamide, proguanil and its active metabolite CPT, 2 : 4-diamino-6 : 7-dinhexylpteridine, and 2 : 4-diamino-6 : 7-diisopropylpteridine. It was as sensitive as the parent strain to quinine, mepacrine, chloroquin, pamaquin, methylene blue, and M 3349.5. The action of sulphadiazine against the sulphadiazine-resistant strain was inhibited by the same doses of p-aminobenzoic acid and folic acid as were required with the parent strain, although the dose of sulphadiazine was increased 30-fold.

scholarly journals The Blood Picture of Pyridoxine Deficiency in the Monkey

Blood ◽  
1952 ◽  
Vol 7 (4) ◽  
pp. 436-444 ◽  
Author(s):  
KENNETH J. POPPEN ◽  
L. D. GREENBERG ◽  
J. F. RINEHART
Keyword(s):  
Folic Acid ◽  
Rhesus Monkeys ◽  
Macrocytic Anemia ◽  
Target Cells ◽  
Severe Anemia ◽  
Low Doses ◽  
Blood Picture ◽  
Pyridoxine Deficiency ◽  
Mean Diameter ◽  
Cell Thickness

Abstract 1. Pyridoxine deficiency in the monkey results in a severe anemia characterized by hypochromia, increase in mean diameter, decrease in mean cell thickness, dehydration, the appearance of "target" cells and increased resistance to hemolysis. 2. The administration of pyridoxine results in restoration of hematologic values to normal, correction of dehydration and disappearance of "target" cells. 3. Further evidence is offered relating "target" cells to dehydration and, in addition, possibly to hepatic damage. 4. A delayed macrocytic anemia which was not corrected by low doses of vitamin B12, folic acid or iron is described in control animals. This anemia occurred chronologically one to two years later than the induced anemia of pyridoxine deficiency and is not necessarily related. The cause of this anemia is unknown. 5. Normal hematologic data on twenty-one M. rhesus monkeys is presented.

The Morphology of the Rat Kidney Following Folic Acid Administration

1970 ◽  
Vol 28 ◽  
pp. 200-201
Author(s):  
Aline Byrnes ◽  
Elsa E. Ramos ◽  
Minoru Suzuki ◽  
E.D. Mayfield
Keyword(s):  
Folic Acid ◽  
De Novo ◽  
Specific Activity ◽  
Rat Kidney ◽  
Present Report ◽  
Intracellular Localization ◽  
Male Rats ◽  
Renal Hypertrophy ◽  
Electron Microscopic ◽  
Biochemical Alterations

Renal hypertrophy was induced in 100 g male rats by the injection of 250 mg folic acid (FA) dissolved in 0.3 M NaHCO3/kg body weight (i.v.). Preliminary studies of the biochemical alterations in ribonucleic acid (RNA) metabolism of the renal tissue have been reported recently (1). They are: RNA content and concentration, orotic acid-c14 incorporation into RNA and acid soluble nucleotide pool, intracellular localization of the newly synthesized RNA, and the specific activity of enzymes of the de novo pyrimidine biosynthesis pathway. The present report describes the light and electron microscopic observations in these animals. For light microscopy, kidney slices were fixed in formalin, embedded, sectioned, and stained with H & E and PAS.

The Response of Testes Cells to Low Level, Single dose Helium Particle Irradiation

1982 ◽  
Vol 40 ◽  
pp. 252-253
Author(s):  
D.E. Philpott ◽  
W. Sapp ◽  
C. Williams ◽  
J. Stevenson ◽  
S. Black ◽  
...  
Keyword(s):  
Stem Cell ◽  
Single Dose ◽  
B Cell ◽  
Cell Survival ◽  
Spermatogonial Stem Cell ◽  
Low Doses ◽  
Particle Irradiation ◽  
Stem Cell Survival ◽  
Irradiation Injury ◽  
Radio Sensitivity

Spermatogonial stem-cell survival after irradiation injury has been studied in rodents by histological counts of surviving cells. Many studies, including previous work from our laboratory, show that the spermatogonial population demonstrates a heterogeneous response to irradiation. The spermatogonia increase in radio-sensitivity as differentiation proceeds through the sequence As - Apr - A1 - A2 - A3 - A4 - In - B. The stem (As) cell is the most resistant and the B cell is the most sensitive. The purpose of this work is to investigate the response of spermatogonial cell to low doses (less than 10 0 rads) of helium particle irradiation.

Potentiation of bromotrichloromethane hepatotoxicity in male rats exposed to 10 ppm dietary chlordecone: Electron Microscopic and biochemical study

1990 ◽  
Vol 48 (3) ◽  
pp. 284-285
Author(s):  
O. M. Faroon ◽  
R. W. Henry ◽  
M. G. Soni ◽  
H. M. Mehendale
Keyword(s):  
Free Radical ◽  
Biochemical Study ◽  
Prior Exposure ◽  
Male Rats ◽  
Cellular Injury ◽  
Low Doses ◽  
Mixed Function Oxidase ◽  
Electron Microscopic ◽  
Potent Inducer ◽  
Cellular Energy

Previous work has shown that mirex undergoes photolytic dechlorination to chlordecone (CD) (KeponeR) in the environment. Much work has shown that prior exposure to nontoxic levels of CD causes potentiation of hepatotoxicity and lethality of CCl4, BrCCl3 and other halomethane compounds. Potentiation of bromotrichloromethane hepatotoxicity has been associated with compounds that stimulate the activity of hepatic mixed-function oxidase (MFO). An increase in the metabolism of halomethane by the MFO to a free radical initiates peroxidative decomposition of membranal lipids ending in massive cellular injury. However, not all MFO inducers potentiate BrCCl3 hepatotoxicity. Potentiation by much larger doses of phenobarbital is minimal and th at by a more potent inducer of MFO, mirex, is negligible at low doses. We suggest that the CD and bromotrichloromethane interaction results in a depletion of cellular energy and thereby reducing the cellular ability to undergo mitosis.

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