scholarly journals Greater whole-body myofibrillar protein breakdown in cachectic patients with chronic obstructive pulmonary disease

2006 ◽  
Vol 83 (4) ◽  
pp. 829-834 ◽  
Author(s):  
Erica PA Rutten ◽  
Frits ME Franssen ◽  
Marielle PKJ Engelen ◽  
Emiel FM Wouters ◽  
Nicolaas EP Deutz ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Myofibrillar Protein ◽  
Whole Body ◽  
Chronic Obstructive ◽  
Protein Breakdown ◽  
Obstructive Pulmonary Disease

scholarly journals Diagnostic performance of lung volumes in assessment of reversibility in chronic obstructive pulmonary disease

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Gamal Agmy ◽  
Manal A. Mahmoud ◽  
Azza Bahaa El-Din Ali ◽  
Mohamed Adam
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Cutoff Point ◽  
Whole Body ◽  
Significant Response ◽  
Chronic Obstructive ◽  
Lung Volumes ◽  
Obstructive Pulmonary Disease ◽  
Gold Stage ◽  
Clinically Significant

Abstract Background Reversibility measured by spirometry in chronic obstructive pulmonary disease (COPD) is defined as an increase in forced expiratory volume in first second (FEV1) that is both more than 12% and 200 mL above the pre-bronchodilator value in response to inhaled bronchodilators. FEV1 only may not fully reverberate the changes caused by reduction in air trapping or hyperinflation. To date, the studies that examined the effect of inhaled bronchodilators (BD) on residual volume (RV) and total lung capacity (TLC) are limited. This study was carried out to assess the differences between flow and volume responses after bronchodilator reversibility testing in patients with different COPD GOLD stages (GOLD stage I to stage IV). Spirometry and whole body plethysmography were done before and 15 min after inhalation of 400 μg salbutamol. Results Majority (53.3%) of cases were volume responders, 18.7% were flow responders, 20% were flow and volume responders, and 8% were non responders. Significant increase in Δ FEV1% was found in 15% of cases while 55% showed a significant increase in Δ FVC (P= < 0.001). Mean difference of Δ FVC (L) post BD was significantly increased with advancing GOLD stage (P= 0.03). A cutoff point > 20% for Δ RV% had 70% sensitivity and 60% specificity and > 12% for Δ TLC% showed 90% sensitivity and 45% specificity for prediction of clinically significant response to BD based on FEV1. A cutoff point > 18% for Δ RV% had 78% sensitivity and 29% specificity and > 14% for Δ TLC% had 50% sensitivity and 70% specificity for prediction of clinically significant response to BD based on FVC. Conclusion ΔFEV1 underestimates the true effect of bronchodilators with advancing GOLD stage. Measurement of lung volumes in addition to the standard spirometric indices is recommended when determining bronchodilator response in COPD patients.

Increased postabsorptive and exercise-induced whole-body glucose production in patients with chronic obstructive pulmonary disease

Metabolism ◽  
2011 ◽  
Vol 60 (7) ◽  
pp. 957-964 ◽  
Author(s):  
Frits M.E. Franssen ◽  
Hans P. Sauerwein ◽  
Mariette T. Ackermans ◽  
Erica P.A. Rutten ◽  
Emiel F.M. Wouters ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Glucose Production ◽  
Whole Body ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Exercise Induced

Enhanced Levels of Whole-body Protein Turnover in Patients with Chronic Obstructive Pulmonary Disease

2000 ◽  
Vol 162 (4) ◽  
pp. 1488-1492 ◽  
Author(s):  
MARIËLLE P. K. J. ENGELEN ◽  
NICOLAAS E. P. DEUTZ ◽  
EMIEL F. M. WOUTERS ◽  
ANNEMIE M. W. J. SCHOLS
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Protein Turnover ◽  
Whole Body ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Body Protein

scholarly journals Chronic Obstructive Pulmonary Disease Does Not Impair Responses to Resistance Training

2021 ◽  
Author(s):  
Knut S. Mølmen ◽  
Daniel Hammarström ◽  
Gunnar S. Falch ◽  
Morten Grundtvig ◽  
Lise Koll ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Resistance Training ◽  
Muscle Strength ◽  
Pulmonary Disease ◽  
Lower Limb ◽  
Endurance Performance ◽  
Whole Body ◽  
Chronic Obstructive ◽  
Core Outcome ◽  
Obstructive Pulmonary Disease

AbstractRationaleSubjects with chronic obstructive pulmonary disease (COPD) are prone to accelerated decay of muscle strength and mass with advancing age. This is mediated by systemic pathophysiologies, which are also believed to impair responses to exercise training, a notion that remains largely unstudied.ObjectivesTo investigate the presence of impaired training responsiveness in COPD, measured as responses to resistance training compared to healthy participants.MethodsCOPD (GOLD grade II-III, n=20, age 69±5) and Healthy (n=58, age 67±4) conducted identical whole-body resistance training interventions, consisting of two weekly, supervised training sessions for 13 weeks. Leg exercises were performed unilaterally, with one leg conducting high-load training (10 repetitions maximum; RM) and the contralateral leg conducting low-load training (30RM).Measurements and Main ResultsMeasurements included muscle strength (n=7), endurance performance (n=6), muscle mass (n=2), muscle quality, muscle biology (vastus lateralis; muscle fiber characteristics, RNA content including transcriptome) and health-related variables (body composition, blood). For core outcome domains, weighted combined factors were calculated from the range of singular assessments.COPD showed marked improvements in lower-limb muscle strength/mass/quality and lower-limb/whole-body endurance performance, resembling or exceeding those of Healthy, measured as both relative and absolute change terms. This was accompanied by similar changes in muscle biological hallmarks (total RNA/rRNA content↑, muscle fiber cross-sectional area↑, type IIX proportions↓, changes in the mRNA transcriptome). Neither of the core outcome domains were differentially affected by resistance training load.ConclusionsCOPD showed marked, unimpaired and hitherto unrecognized responsiveness to resistance training, rejecting the notion of disease-related impairments in training responsiveness.

scholarly journals Neutrophilic Inflammation in the Immune Responses of Chronic Obstructive Pulmonary Disease: Lessons from Animal Models

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Gang Huang ◽  
Xu-Chen Xu ◽  
Jie-Sen Zhou ◽  
Zhou-Yang Li ◽  
Hai-Pin Chen ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Animal Models ◽  
Immune Responses ◽  
Pulmonary Disease ◽  
Whole Body ◽  
Chronic Obstructive ◽  
Small Airways ◽  
Obstructive Pulmonary Disease ◽  
Neutrophilic Inflammation ◽  
Advantages And Disadvantages

Chronic obstructive pulmonary disease (COPD) is a major cause of mortality worldwide, which is characterized by chronic bronchitis, destruction of small airways, and enlargement/disorganization of alveoli. It is generally accepted that the neutrophilic airway inflammation observed in the lungs of COPD patients is intrinsically linked to the tissue destruction and alveolar airspace enlargement, leading to disease progression. Animal models play an important role in studying the underlying mechanisms of COPD as they address questions involving integrated whole body responses. This review aims to summarize the current animal models of COPD, focusing on their advantages and disadvantages on immune responses and neutrophilic inflammation. Also, we propose a potential new animal model of COPD, which may mimic the most characteristics of human COPD pathogenesis, including persistent moderate-to-high levels of neutrophilic inflammation.

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