scholarly journals Evaluation of vitamin A supplementation regimens in Ghanaian postpartum mothers with the use of the modified-relative-dose-response test

2006 ◽  
Vol 84 (6) ◽  
pp. 1344-1349 ◽  
Author(s):  
Samuel K Tchum ◽  
Sherry A Tanumihardjo ◽  
Samuel Newton ◽  
Bruno de Benoist ◽  
Seth Owusu-Agyei ◽  
...  
Keyword(s):  
Vitamin A ◽  
Dose Response ◽  
Vitamin A Supplementation ◽  
Response Test ◽  
Postpartum Mothers ◽  
Modified Relative Dose Response

scholarly journals Vitamin A intake and infection are associated with plasma retinol among pre-school children in rural Zambia

2012 ◽  
Vol 15 (9) ◽  
pp. 1688-1696 ◽  
Author(s):  
Christine Hotz ◽  
Justin Chileshe ◽  
Ward Siamusantu ◽  
Uma Palaniappan ◽  
Emmanuel Kafwembe
Keyword(s):  
Vitamin A ◽  
Dose Response ◽  
Acute Phase Proteins ◽  
Vitamin A Deficiency ◽  
Dietary Vitamin ◽  
Response Test ◽  
Post Harvest ◽  
Vitamin A Status ◽  
Plasma Retinol ◽  
Modified Relative Dose Response

AbstractObjectiveTo determine the prevalence of vitamin A deficiency, infection and adequacy of vitamin A intakes among Zambian children, and the contribution of dietary vitamin A and infection to vitamin A status.DesignA cross-sectional survey of vitamin A intakes by the 24 h recall method, vitamin A status by plasma retinol and the modified relative dose-response test, and infection by acute-phase proteins.SettingRural communities in Central and Eastern Provinces of Zambia.SubjectsChildren 2–5 years of age.ResultsThe prevalence of vitamin A deficiency was 56 % by plasma retinol, 48 % with infection-adjusted plasma retinol and 22 % by the modified relative dose-response test. The majority of children (61 %) had a current infection. Vitamin A intakes were relatively high (331 to 585 μg retinol activity equivalents/d in the harvest/early post-harvest and late post-harvest seasons, respectively) and the prevalence of inadequate intakes was <1 % when compared with the Estimated Average Requirement (210 and 275 μg retinol activity equivalents/d for children aged 1–3 and 4–8 years, respectively). Elevated α-1-acid glycoprotein was negatively associated with plasma retinol (P< 0·0 0 1) and vitamin A intake was positively associated with plasma retinol (P< 0·05), but only when estimated assuming a 26:1 retinol equivalence for provitamin A from green and yellow vegetables.ConclusionsInfection and vitamin A intakes were significant determinants of plasma retinol. We cannot conclude which indicator more accurately represents the true vitamin A status of the population. Reasons for the persistent high prevalence of vitamin A deficiency in the presence of adequate vitamin A intakes are unclear, but the high rates of infection may play a role.

The Vitamin A Status of Zambian Children in a Community of Vitamin A Supplementation and Sugar Fortification Strategies as measured by the Modified Relative Dose Response (MRDR) Test

2009 ◽  
Vol 79 (1) ◽  
pp. 40-47 ◽  
Author(s):  
Emmanuel M. Kafwembe ◽  
James Chipipa ◽  
Eric Njunju ◽  
Roma Chilengi
Keyword(s):  
Vitamin A ◽  
Dose Response ◽  
Vitamin A Deficiency ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Vitamin A Supplementation ◽  
Vitamin A Status ◽  
The Status ◽  
Modified Relative Dose Response

The main objective of the study was to determine the vitamin A status of Zambian children less than five years of age in a community where strategies of vitamin A supplementation and consumption of vitamin A fortified sugar have been introduced. In a cross-sectional study, a total of 537 children were enrolled. Their vitamin A status was measured using the modified relative dose response (MRDR) test. Their vitamin A status was compared to the status measured using a similar method in 1996, before vitamin A supplementation through capsule distribution and fortification of sugar was implemented as strategies to reduce vitamin A deficiency in the country. Results showed that the vitamin A status of children improved markedly as a result of these strategies.

scholarly journals Improved Method for Measurement of Retinol and Didehydroretinol in the Modified Relative Dose Response Test to Detect Vitamin A Deficiency

2003 ◽  
Vol 49 (2) ◽  
pp. 338-339 ◽  
Author(s):  
Juergen G Erhardt ◽  
Hans K Biesalski ◽  
Lucie C Malaba ◽  
Neal E Craft
Keyword(s):  
Vitamin A ◽  
Dose Response ◽  
Vitamin A Deficiency ◽  
Improved Method ◽  
Response Test ◽  
Modified Relative Dose Response

scholarly journals High Prevalence of Vitamin A Deficiency Is Detected by the Modified Relative Dose-Response Test in Six-Month-Old Senegalese Breast-Fed Infants

2012 ◽  
Vol 142 (11) ◽  
pp. 1991-1996 ◽  
Author(s):  
Anta Agne-Djigo ◽  
Nicole Idohou-Dossou ◽  
Komlan M. Kwadjode ◽  
Sherry A. Tanumihardjo ◽  
Salimata Wade
Keyword(s):  
Vitamin A ◽  
Dose Response ◽  
Vitamin A Deficiency ◽  
Response Test ◽  
High Prevalence ◽  
Breast Fed ◽  
Modified Relative Dose Response

scholarly journals Refinement of the modified-relative-dose-response test as a method for assessing vitamin A status in a field setting: experience with Indonesian children

1996 ◽  
Vol 64 (6) ◽  
pp. 966-971 ◽  
Author(s):  
S A Tanumihardjo ◽  
J C Cheng ◽  
D Permaesih ◽  
Muherdiyantiningsih ◽  
E Rustan ◽  
...  
Keyword(s):  
Vitamin A ◽  
Dose Response ◽  
Response Test ◽  
Vitamin A Status ◽  
Field Setting ◽  
Modified Relative Dose Response

scholarly journals Adequate vitamin A liver stores estimated by the modified relative dose response test are positively associated with breastfeeding but not vitamin A supplementation in Senegalese urban children 9–23 months old: A comparative cross-sectional study

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0246246
Author(s):  
Mane Hélène Faye ◽  
Marie-Madeleine A. Diémé ◽  
Nicole Idohou-Dossou ◽  
Abdou Badiane ◽  
Adama Diouf ◽  
...  
Keyword(s):  
Vitamin A ◽  
Dose Response ◽  
Cross Sectional Study ◽  
Dietary Vitamin ◽  
Sectional Study ◽  
Hypervitaminosis A ◽  
Cross Sectional ◽  
Vitamin A Supplementation ◽  
Age Related ◽  
Modified Relative Dose Response

Vitamin A supplementation (VAS) in 6-59-month-old children is recommended but its sustainability is currently questioned. In Senegal, available data suggest that VAS should be maintained, but geographic and age-related specificities need to be addressed to better implement and target VAS programming. The objective of this comparative cross-sectional study, conducted in urban settings of Dakar, was to compare the vitamin A liver stores (VALS) assessed using the modified-relative dose response (MRDR) test between supplemented and non-supplemented 9–23 month-old children and to study their relationship with VAS. The supplemented group (n = 119) received VAS (either 100 000 UI or 200 000 UI) 2 to 6 months before evaluation while the non-supplemented group (n = 110) had not received VAS during the past 6 months. In addition to MRDR, serum retinol concentrations (SR), and biomarkers of subclinical inflammation were measured. Children’s health-related data and feeding patterns were collected. Mean MRDR values (VAS: 0.030 ± 0.017, non-VAS: 0.028 ± 0.016, P = 0.389) and inflammation-adjusted SR (VAS: 1.34 ± 0.37, non-VAS: 1.3 ± 0.35, P = 0.515) of children were adequate. Low prevalence of VALS (VAS: 5.2%, non-VAS: 5.4%) and inflammation-adjusted VAD (VAS: 2.6%, non-VAS: 0.9%) were detected despite high presence of infections and inflammation. Children were mostly still being breastfed (VAS: 85.7%, non-VAS: 77.3%) and complementary feeding indicators were similar in both groups. Only breastfeeding was associated with VALS and was found to reduce by 76% at least, the odds of VAD (adjusted OR = 0.24, 95% CI: 0.07–0.8, P = 0.020). Based on MRDR values, VAS was not related to improved VALS and SR as well as VAD reduction among these children with adequate VALS. Reinforcing breastfeeding advocacy and morbidity prevention/control are essential in this setting. Scaling-back VAS in this subpopulation should be examined regarding the risk of hypervitaminosis A after an evaluation of dietary vitamin A intake sufficiency and a more quantitative assessment of VALS.

Vitamin A status in preschool-age Indonesian children as assessed by the modified relative-dose-response assay

1990 ◽  
Vol 52 (6) ◽  
pp. 1068-1072 ◽  
Author(s):  
S A Tanumihardjo ◽  
Muhilal ◽  
Y Yuniar ◽  
D Permaesih ◽  
Z Sulaiman ◽  
...  
Keyword(s):  
Vitamin A ◽  
Dose Response ◽  
Preschool Age ◽  
Vitamin A Status ◽  
Modified Relative Dose Response
Sign in / Sign up

Export Citation Format

Share Document