Lymphocyte Surface Markers in Acute Lymphoblastic Leukemia of Adults

Abstract In six patients with acute leukemia (about 2% of the patients referred for acute lymphoblastic leukemia) the blast cells invading bone marrow and blood showed all the cytologic, cytochemical, and electron microscopy features of Burkitt's tumor cells. The presence of monoclonal surface immunoglobulins (their synthesis being proved by in vitro culture experiments), the binding of IgG aggregates, and the absence of rosette formation with sheep red cells documented the monoclonal B-cell origin of these blast cells which is in sharp contrast to the findings in common acute lymphoblastic leukemia. The course of the disease was usually rapidly fatal without chemotherapy- induced remission.

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The occurrence of the HL-B alloantigens on the cells of unclassified acute lymphoblastic leukemias.

Journal of Experimental Medicine ◽

10.1084/jem.142.5.1334 ◽

1975 ◽

Vol 142 (5) ◽

pp. 1334-1338 ◽

Cited By ~ 60

Author(s):

S M Fu ◽

R J Winchester ◽

H G Kunkel

Keyword(s):

Acute Lymphoblastic Leukemia ◽

B Cell ◽

B Lymphocyte ◽

Lymphoblastic Leukemia ◽

Sheep Erythrocyte ◽

Cell Lineage ◽

The Other ◽

Surface Markers ◽

Positive Group ◽

Lymphocyte Surface Markers

Six cases of acute lymphoblastic leukemia were studied by a variety of T- and B-lymphocyte surface markers. Two appeared to represent T-cell leukemias with the lymphoblasts forming sheep erythrocyte rosettes. The other four lacked all the usual membrane markers. However, indirect immunofluorescence with alloantisera detected the presence of the Ia-related HL-B antigens on the cells of the latter four cases; these antigens were absent in the first two cases. The primary association of the HL-B antigens with B cells raises the possibility that the positive group of cases are of B-cell lineage.

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Acute leukemia with Burkitt's tumor cells: A study of six cases with special reference to lymphocyte surface markers

Blood ◽

10.1182/blood.v45.2.183.bloodjournal452183 ◽

1975 ◽

Vol 45 (2) ◽

pp. 183-188 ◽

Cited By ~ 1

Author(s):

G Flandrin ◽

JC Brouet ◽

MT Daniel ◽

JL Preud'homme

Keyword(s):

Electron Microscopy ◽

Acute Lymphoblastic Leukemia ◽

Acute Leukemia ◽

Tumor Cells ◽

Lymphoblastic Leukemia ◽

Surface Markers ◽

Lymphocyte Surface Markers ◽

Surface Immunoglobulins ◽

Blast Cells

In six patients with acute leukemia (about 2% of the patients referred for acute lymphoblastic leukemia) the blast cells invading bone marrow and blood showed all the cytologic, cytochemical, and electron microscopy features of Burkitt's tumor cells. The presence of monoclonal surface immunoglobulins (their synthesis being proved by in vitro culture experiments), the binding of IgG aggregates, and the absence of rosette formation with sheep red cells documented the monoclonal B-cell origin of these blast cells which is in sharp contrast to the findings in common acute lymphoblastic leukemia. The course of the disease was usually rapidly fatal without chemotherapy- induced remission.

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