The Clinical Relevance of Lymphocyte Surface Markers in Adult Acute Lymphoblastic Leukemia

Abstract In six patients with acute leukemia (about 2% of the patients referred for acute lymphoblastic leukemia) the blast cells invading bone marrow and blood showed all the cytologic, cytochemical, and electron microscopy features of Burkitt's tumor cells. The presence of monoclonal surface immunoglobulins (their synthesis being proved by in vitro culture experiments), the binding of IgG aggregates, and the absence of rosette formation with sheep red cells documented the monoclonal B-cell origin of these blast cells which is in sharp contrast to the findings in common acute lymphoblastic leukemia. The course of the disease was usually rapidly fatal without chemotherapy- induced remission.

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The occurrence of the HL-B alloantigens on the cells of unclassified acute lymphoblastic leukemias.

Journal of Experimental Medicine ◽

10.1084/jem.142.5.1334 ◽

1975 ◽

Vol 142 (5) ◽

pp. 1334-1338 ◽

Cited By ~ 60

Author(s):

S M Fu ◽

R J Winchester ◽

H G Kunkel

Keyword(s):

Acute Lymphoblastic Leukemia ◽

B Cell ◽

B Lymphocyte ◽

Lymphoblastic Leukemia ◽

Sheep Erythrocyte ◽

Cell Lineage ◽

The Other ◽

Surface Markers ◽

Positive Group ◽

Lymphocyte Surface Markers

Six cases of acute lymphoblastic leukemia were studied by a variety of T- and B-lymphocyte surface markers. Two appeared to represent T-cell leukemias with the lymphoblasts forming sheep erythrocyte rosettes. The other four lacked all the usual membrane markers. However, indirect immunofluorescence with alloantisera detected the presence of the Ia-related HL-B antigens on the cells of the latter four cases; these antigens were absent in the first two cases. The primary association of the HL-B antigens with B cells raises the possibility that the positive group of cases are of B-cell lineage.

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Acute leukemia with Burkitt's tumor cells: A study of six cases with special reference to lymphocyte surface markers

Blood ◽

10.1182/blood.v45.2.183.bloodjournal452183 ◽

1975 ◽

Vol 45 (2) ◽

pp. 183-188 ◽

Cited By ~ 1

Author(s):

G Flandrin ◽

JC Brouet ◽

MT Daniel ◽

JL Preud'homme

Keyword(s):

Electron Microscopy ◽

Acute Lymphoblastic Leukemia ◽

Acute Leukemia ◽

Tumor Cells ◽

Lymphoblastic Leukemia ◽

Surface Markers ◽

Lymphocyte Surface Markers ◽

Surface Immunoglobulins ◽

Blast Cells

In six patients with acute leukemia (about 2% of the patients referred for acute lymphoblastic leukemia) the blast cells invading bone marrow and blood showed all the cytologic, cytochemical, and electron microscopy features of Burkitt's tumor cells. The presence of monoclonal surface immunoglobulins (their synthesis being proved by in vitro culture experiments), the binding of IgG aggregates, and the absence of rosette formation with sheep red cells documented the monoclonal B-cell origin of these blast cells which is in sharp contrast to the findings in common acute lymphoblastic leukemia. The course of the disease was usually rapidly fatal without chemotherapy- induced remission.

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Faculty Opinions recommendation of Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1088852.541966 ◽

2007 ◽

Author(s):

Thomas Habermann

Keyword(s):

Acute Lymphoblastic Leukemia ◽

Prognostic Factor ◽

Medical Research ◽

Research Council ◽

Medical Research Council ◽

Lymphoblastic Leukemia ◽

Eastern Cooperative Oncology Group ◽

Independent Prognostic Factor ◽

Oncology Group ◽

Adult Acute Lymphoblastic Leukemia

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The presence of TEL/AML1 rearrangement and cryptic deletion of the TEL gene in adult acute lymphoblastic leukemia (ALL)

Cancer Genetics and Cytogenetics ◽

10.1016/j.cancergencyto.2005.02.020 ◽

2005 ◽

Vol 162 (2) ◽

pp. 176-178 ◽

Cited By ~ 10

Author(s):

Dong Soon Lee ◽

Young Ree Kim ◽

Hyung Kyun Cho ◽

Chung Kee Lee ◽

Jee Hyung Lee ◽

...

Keyword(s):

Acute Lymphoblastic Leukemia ◽

Lymphoblastic Leukemia ◽

Adult Acute Lymphoblastic Leukemia

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Treatment of adult acute lymphoblastic leukemia with intensive cyclical chemotherapy: a follow-up report

Blood ◽

10.1182/blood.v78.11.2814.2814 ◽

1991 ◽

Vol 78 (11) ◽

pp. 2814-2822 ◽

Cited By ~ 121

Author(s):

CA Linker ◽

LJ Levitt ◽

M O'Donnell ◽

SJ Forman ◽

CA Ries

Keyword(s):

Acute Lymphoblastic Leukemia ◽

Lymphoblastic Leukemia ◽

Disease Free Survival ◽

Remission Induction ◽

Cell Phenotype ◽

Free Survival ◽

Prognostic Features ◽

Adult Acute Lymphoblastic Leukemia ◽

Disease Free

Abstract We treated 109 patients with adult acute lymphoblastic leukemia (ALL) diagnosed by histochemical and immunologic techniques. Patients were excluded only for age greater than 50 years and Burkitt's leukemia. Treatment included a four-drug remission induction phase followed by alternating cycles of noncrossresistant chemotherapy and prolonged oral maintenance therapy. Eighty-eight percent of patients entered complete remission. With a median follow-up of 77 months (range, 48 to 111 months), 42% +/- 6% (SEM) of patients achieving remission are projected to remain disease-free at 5 years, and disease-free survival for all patients entered on study is 35% +/- 5%. Failure to achieve remission within the first 4 weeks of therapy and the presence of the Philadelphia chromosome are associated with a 100% risk of relapse. Remission patients with neither of these adverse features have a 48% +/- 6% probability of remaining in continuous remission for 5 years. Patients with T-cell phenotype have a favorable prognosis with 59% +/- 13% of patients achieving remission remaining disease-free compared with 31% +/- 7% of CALLA-positive patients. Intensive chemotherapy may produce prolonged disease-free survival in a sizable fraction of adults with ALL. Improved therapy is needed, especially for patients with adverse prognostic features.

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