Loss of WT1 Expression After Chemotherapy in a Primary Peritoneal Serous Carcinoma: A Case Report

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S39-S39
Author(s):  
Francia Victoria De Los Reyes
Keyword(s):  
Case Report ◽  
Malignant Neoplasm ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Serous Carcinoma ◽  
En Bloc ◽  
Abdominal Girth ◽  
Small Surface ◽  
P53 Expression ◽  
Platinum Based Chemotherapy

Abstract Objectives Primary peritoneal serous carcinoma (PPSC) is defined as a high-grade malignant neoplasm with widespread peritoneal involvement in the setting of normal-sized ovaries that contain small surface tumoral implants and no other identifiable source of malignant serous neoplasm elsewhere in the gynecologic tract. Methods The aim of this case report is to contribute to the understanding of tumor immunophenotype and describe the behavior of a primary peritoneal serous carcinoma in relation to the conversion of the tumor’s WT1 immunohistochemistry expression from positive to negative after chemotherapy. Results This is a case of a 72-year-old female that presented with a history of increasing abdominal girth of 12 months. She underwent biopsy of the omentum and was diagnosed to have metastatic carcinoma that was positive for WT1, PAX8, CK7, and ER. The patient was initially diagnosed and managed as a case of ovarian serous carcinoma with metastasis to the omentum. She underwent neoadjuvant platinum-based chemotherapy and en-bloc total abdominal hysterectomy with bilateral salpingo-oophorectomy and low anterior resection, with metastasis resection. The criteria of PPSC were fulfilled due to the normal-sized ovaries and minimal ovarian involvement with normal fallopian tubes. Immunohistochemistry of the resection specimen showed negative WT1 and PAX8, and positive ER, CK, and p16 expression, with null p53 expression. Conclusion Following the concept that WT1 expression portends a poorer prognosis, the loss of WT1 expression may be a positive response to the chemotherapy and should be correlated with the time to recurrence. The patient was noted to be recurrence free for 1 year and still does not show signs of the disease at present. This is the first documented case of a previously WT1-positive primary peritoneal serous carcinoma that converted to a negative WT1 expression. This may provide insight on the role of chemotherapy in silencing protein expression.

Uterine-like Mass With Features of an Extrauterine Adenomyoma Presenting 22 Years After Total Abdominal Hysterectomy–Bilateral Salpingo-oophorectomy: A Case Report and Review of the Literature

2005 ◽  
Vol 129 (8) ◽  
pp. 1041-1043 ◽  
Author(s):  
Rachel Redman ◽  
Edward J. Wilkinson ◽  
Nicole A. Massoll
Keyword(s):  
Smooth Muscle ◽  
Case Report ◽  
Benign Tumor ◽  
Broad Ligament ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Rare Entity ◽  
Review Of The Literature ◽  
Hormonal Stimulation ◽  
Pelvic Organs

Abstract Adenomyoma is a benign tumor composed of smooth muscle and benign endometrium. These tumors typically originate within the uterus. An extrauterine adenomyoma is a rare entity. We report a uterine-like mass consistent with an extrauterine adenomyoma presenting 22 years following a total abdominal hysterectomy and bilateral salpingo-oophorectomy. The mass was pear-shaped with uterine-type smooth muscle and a cavity lined by functional endometrial glands and stroma. To our knowledge, only 4 other cases of an extrauterine uterine-like mass are reported in the literature. Three involved the ovary, while one was located adjacent to the broad ligament with normal pelvic organs. Although none of these other uterus-like masses were described as adenomyomas with uterine-like features, the histologic findings are strikingly similar. An understanding of the müllerian system suggests that either an embryologic malformation or a differential multipotentiality existing in the subcoelomic tissues in response to hormonal stimulation results in a supernumerary müllerian structure like a uterus, as observed in this case. The presence of endometrial glands and stroma in the mass confirms that the tissues in this mass are hormonally responsive. It is most likely that this uterine-like mass arose from the tissues of the secondary müllerian system in response to estrogenic stimulation.

Cervical Ectopic Pregnancy: Case Report

1970 ◽  
Vol 25 (2) ◽  
pp. 92-94
Author(s):  
Laila Parveen Banu ◽  
Sameena Chowdhury ◽  
Kohinoor Begum ◽  
Ferdousi Islam ◽  
Saria Tasnim
Keyword(s):  
Case Report ◽  
Ectopic Pregnancy ◽  
Vaginal Bleeding ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Naked Eye ◽  
Life Threatening ◽  
Eye Examination ◽  
Cervical Ectopic Pregnancy

A thirty year old lady para 3+0 presented with complaints of amenorrhoea for eight weeks and slight per vaginal bleeding for 28 days with frequent bouts of profuse bleeding. Total abdominal hysterectomy was done. Naked eye examination of the specimen was suggestive of cervical ectopic pregnancy (CEP). Histopathology report confirmed cervical implantation of placenta. CEP is an extremely rare life threatening form of ectopic pregnancy. (J Bangladesh Coll Phys Surg 2007; 25 : 92-94)

Cure of metastatic uterine carcinosarcoma to lungs: A case report

2003 ◽  
Vol 13 (1) ◽  
pp. 88-89
Author(s):  
A. Shamseddine ◽  
A. Taher ◽  
Y. Abou-Mourad ◽  
M. Seoud ◽  
A. Khalil
Keyword(s):  
Case Report ◽  
Systemic Chemotherapy ◽  
Pulmonary Nodules ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Uterine Sarcoma ◽  
Uterine Carcinosarcoma ◽  
Pelvic Radiotherapy ◽  
Term Survival

Most patients with advanced or recurrent uterine sarcoma experience disease progression and ultimately die. We present a case of uterine sarcoma with lung metastasis treated with systemic chemotherapy and with no evidence of disease for more than 5 years. A 77-year-old woman underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy for carcinosarcoma of the uterus followed by external pelvic radiotherapy. Ten months later, the tumor recurred in the apex of the vagina and was treated with brachytherapy. After 6 months of remission, she presented with pulmonary metastasis. After four cycles of systemic chemotherapy with cisplatin and ifosfamide, the pulmonary nodules completely disappeared. Currently she is still in complete remission after more than 5 years, but unfortunately she has developed myelodysplastic syndrome. This is the first reported case in the literature of cured metastatic uterine carcinosarcoma to lungs, with long-term survival of 5 years.

Mucoepidermoid variant of adenosquamous carcinoma arising in ovarian dermoid cyst: a case report and review of the literature

2006 ◽  
Vol 16 (Suppl 1) ◽  
pp. 379-384
Author(s):  
A. Karateke ◽  
A. Gurbuz ◽  
G. Kir ◽  
B. Haliloglu ◽  
C. Kabaca ◽  
...  
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Dermoid Cyst ◽  
Adenosquamous Carcinoma ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Review Of The Literature ◽  
Lymph Node Sampling ◽  
Aortic Lymph Node ◽  
Ovarian Dermoid Cyst

A 40-year-old woman with mucoepidermoid variant of adenosquamous carcinoma arising in dermoid cyst in left ovary is presented. The patient was staged as IC. Total abdominal hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and pelvic and para-aortic lymph node sampling were carried out. The disease recurred in postoperative 12th month. To our best knowledge, this is 12th case of adenosquamous carcinoma in dermoid cyst and third case of mucoepidermoid variant of adenosquamous carcinoma in the literature.

scholarly journals The Smallest Reported Malignant Struma Ovarii: A Case Report

2018 ◽  
Vol 11 (3) ◽  
pp. 693-698 ◽  
Author(s):  
Nobuko Yasutake ◽  
Hirotsugu Noguchi ◽  
Yuta Ibayashi ◽  
Hiroaki Nakamura ◽  
Kazuki Tateishi ◽  
...  
Keyword(s):  
Case Report ◽  
Treatment Decision ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Struma Ovarii ◽  
Malignant Struma Ovarii ◽  
Gynecology And Obstetrics ◽  
Good Clinical Condition ◽  
Stage Ia ◽  
Peripheral Areas

Introduction: Malignant struma ovarii is a rare neoplasm. It is usually asymptomatic and not commonly diagnosed preoperatively. In addition, there is currently no established diagnostic and therapeutic approach for malignant struma ovarii. Case Report: A 66-year-old asymptomatic female was referred to our hospital. Computed tomography showed the presence of a well-defined mass with enhancement in the internal and peripheral areas. The patient underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy, and partial omentectomy. Histopathology revealed the presence of a papillary thyroid carcinoma arising from a 2.5-cm-diameter struma ovarii (malignant struma ovarii). According to the criteria of the International Federation of Gynecology and Obstetrics, the patient had stage IA disease. Subsequently, she underwent a thyroid scan with normal findings. At the 3-month follow-up, the patient was alive, in good clinical condition, and disease free. Conclusion: In this report, we present the smallest malignant struma ovarii reported so far in the literature. Because of the rarity of these tumors and the lack of firm prognostic factors, the treatment decision should be customized for each patient according to the pathological and clinical parameters.

C0466: Total Abdominal Hysterectomy and Postoperative Bleeding Diathesis: A Case Report

2014 ◽  
Vol 133 ◽  
pp. S57
Author(s):  
T. Vucemilo ◽  
M. Puljiz ◽  
I. Alvir ◽  
I. Mamic ◽  
M. Skoko
Keyword(s):  
Case Report ◽  
Postoperative Bleeding ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Bleeding Diathesis

scholarly journals Torsion of a Uterine Leiomyoma: A Case Report and Review of the Literature

2011 ◽  
Vol 4 ◽  
pp. CMWH.S6780 ◽  
Author(s):  
N.M. Ward ◽  
M.K. Frey ◽  
B.D. Shaktman
Keyword(s):  
Abdominal Pain ◽  
Case Report ◽  
Uterine Leiomyoma ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Review Of The Literature ◽  
Fibroid Uterus

A 55 year-old woman presented with abdominal pain. Transvaginal ultasonography demonstrated an enlarged fibroid uterus. She underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy and was found to have torsion of a large pedunculated leiomyoma. There are fewer than 10 cases reported in the literature of torsion of a uterine leiomyoma.

scholarly journals Submucosal Uterine Fibroid in Grand Multipara Woman: A Case Report

2021 ◽  
Vol 9 (T3) ◽  
pp. 27-30
Author(s):  
Muhammad Rusda ◽  
Arvitamuriany Triyanthi Lubis ◽  
Muhammad Ramadhan Hisworo ◽  
Andrina Yunita Murni Rambe
Keyword(s):  
Case Report ◽  
Uterine Fibroid ◽  
Normal Limit ◽  
Transvaginal Ultrasound ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Normal Limits ◽  
Grand Multiparity ◽  
Chief Complaints ◽  
One Year

Background: to report and analyze a case that diagnosed with submocous uterine fibroid in grand multiparity woman. Methods: Case Report Case: a 49 years woman, P7A0 came with chief complaints vaginal bleeding that has been experienced since one year ago getting worse in 2 months. Her general condition was within normal limit and there was no abnormality in physical examination, by vaginal examination there was blood in the vagina, origin from the External Uterine Orificium (EUO),bimanual examination showed anteflexion uterus with normal size, right and left adnexa within normal limits. From transvaginal ultrasound we found submucous uterine fibroid size 3 x 3 cm, we decided to perform Total Abdominal Hysterectomy. Conclusion: Hysterectomy is a progressive and definitive uterine fibroid procedure. For women who do not want to conceive and/or women over 40-50 years of age, in particular.

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