Comparison of Address-based Sampling and Random-digit Dialing Methods for Recruiting Young Men as Controls in a Case-Control Study of Testicular Cancer Susceptibility

AbstractTesticular cancer is the commonest malignancy arising in men actively serving in the Royal Navy. This study, which includes a literature review of the aetiology of the disease, is designed to determine the relative risk of developing testicular cancer in various occupational groups within the Service by means of a Case-Control study. All cases of testicular cancer occurring in serving personnel between 1976 and June 1994, inclusive, were identified. One hundred and ten cases were found. Four randomly selected controls were matched on the basis of date of birth and length of service to each case. Results reveal statistically significant increased Odds Ratios for members of the Fleet Air Arm (OR=1.90 95% Cl : 1.04–.48), Air Engineers (OR=2.32 95% Cl: 1.20–4.48) and the Aircraft Handling sub-speciality (OR=7.31 95% Cl: 1.81–29.53). It is speculated that exposure to glycol ethers in aviation fuel may be the causative mechanism. No associations were found in relation to ionising radiation exposures or length of time served in nuclear submarines.

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Polymorphisms in IL‐1A are associated with endometrial cancer susceptibility among Chinese Han population: A case–control study

International Journal of Immunogenetics ◽

10.1111/iji.12463 ◽

2020 ◽

Vol 47 (2) ◽

pp. 169-174

Author(s):

Ying Liu ◽

Yao Sun ◽

Jiamin Wu ◽

Zichao Xiong ◽

Shuli Du ◽

...

Keyword(s):

Endometrial Cancer ◽

Case Control Study ◽

Cancer Susceptibility ◽

Case Control ◽

Chinese Han Population ◽

Chinese Han ◽

Han Population ◽

Control Study

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Functional variants of lncRNA LINC00673 and gastric cancer susceptibility: a case-control study in a Chinese population

Cancer Management and Research ◽

10.2147/cmar.s187011 ◽

2019 ◽

Vol Volume 11 ◽

pp. 3861-3868 ◽

Cited By ~ 3

Author(s):

Kexin Zhao ◽

Rui Zhang ◽

Tiantian Li ◽

Zhifan Xiong

Keyword(s):

Gastric Cancer ◽

Chinese Population ◽

Case Control Study ◽

Cancer Susceptibility ◽

Case Control ◽

Functional Variants ◽

Control Study

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Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis

Disease Markers ◽

10.1155/2017/4731891 ◽

2017 ◽

Vol 2017 ◽

pp. 1-9 ◽

Cited By ~ 7

Author(s):

Yanhua Wu ◽

Zhifang Jia ◽

Donghui Cao ◽

Chuan Wang ◽

Xing Wu ◽

...

Keyword(s):

Gastric Cancer ◽

Survival Analysis ◽

Distant Metastasis ◽

Case Control Study ◽

Cancer Susceptibility ◽

Case Control ◽

Cancer Prognosis ◽

Radical Operation ◽

Risk Of Death ◽

Control Study

Gastric cancer (GC) is one of the most prominent global cancer-related health threats. Genes play a key role in the precise mechanisms of gastric cancer. SNPs in mi-RNAs could affect mRNA expression and then affect the risk and prognosis of GC. Firstly, we have decided to perform a case-control study which included 897 GC patients and 992 controls to evaluate the association of miR-219-1 rs213210, miR-938 rs2505901, miR-34b/c rs4938723, and miR-218 rs11134527 polymorphisms with gastric cancer susceptibility. Secondly, among the 897 GC patients above, 755 cases underwent a radical operation, without distant metastasis and with negative surgical margins included in the survival analysis to evaluate the association of the four SNPs above with gastric cancer prognosis. The C/T or C/C genotypes of rs213210 were related to a lower GC risk (OR = 0.76, 95% CI: 0.62–0.93,P=0.009) compared to the T/T genotype. Rs11134527 in miR-218 was associated with GC survival, and the G/A and G/G genotypes of rs11134527 resulted in a decreased risk of death when compared with the A/A genotype (HR = 0.75, 95% CI: 0.61–0.95,P=0.016). This study found that miR-219-1 rs213210 polymorphism was associated with GC susceptibility and rs11134527 in miR-218 was positively correlated with GC prognosis.

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