S18-2HOW TO DIAGNOSE AND TREAT SAFELY ALCOHOL DEPENDENCE IN PATIENTS WITH ALCOHOLIC LIVER DISEASE?

Background: Alcoholism is a potentially fatal condition damages skin directly or through organ dysfunction. Studies suggested that dermatological manifestations have also been found to be a marker of alcohol misuse. The aim of the study was to assess the various cutaneous manifestations of alcohol dependence.Methods: This study consisted of 205 cases diagnosed with alcohol dependency attending dermatology department and psychiatry wards, above 18 years of age. A detailed clinical examination and dermatological examination including hair, nails, oral and genital mucosa was performed. Alcoholic liver disease was diagnosed on clinical findings, abdominal sonogram and LFT.Results: Among the study cases 50.25% cases had alcoholic liver disease. The severity of alcohol dependence score ranged from 1-60 with Ameena score of 24.68. It was seen that 45.23% (90) of alcoholics were mildly dependent, 41.7% (83) of alcoholics were moderately dependent, and 13.07% (26) were severely dependent on alcohol. Seborrheic dermatitis, urticaria, hyperhidrosis was among the commonly encountered dermatoses.Conclusions: Cutaneous manifestations are a significant pointer to underlying, perhaps undetected problem of alcohol dependency and an awareness of these signs is imperative to alter a dermatologist to problems of alcohol abuse even in a busy clinic.

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Severity of alcohol dependence in patients with alcoholic liver disease.

BMJ ◽

10.1136/bmj.287.6403.1420 ◽

1983 ◽

Vol 287 (6403) ◽

pp. 1420-1422 ◽

Cited By ~ 56

Author(s):

A D Wodak ◽

J B Saunders ◽

I Ewusi-Mensah ◽

M Davis ◽

R Williams

Keyword(s):

Liver Disease ◽

Alcohol Dependence ◽

Alcoholic Liver Disease

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Identification and management of alcohol dependence and withdrawal in alcoholic liver disease

Clinical Liver Disease ◽

10.1002/cld.194 ◽

2013 ◽

Vol 2 (2) ◽

pp. 57-60

Author(s):

Jody B. Glance ◽

Andrea DiMartini

Keyword(s):

Liver Disease ◽

Alcohol Dependence ◽

Alcoholic Liver Disease

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Role of peroxisome proliferator-activated receptors in the control of alcohol dependence and concomitant liver pathology

Proceedings of the National Academy of Sciences of Belarus Medical series ◽

10.29235/1814-6023-2019-16-2-244-256 ◽

2019 ◽

Vol 16 (2) ◽

pp. 244-256

Author(s):

I. N. Semenenya ◽

A. H. Shlyahtun ◽

H. F. Raduta

Keyword(s):

Liver Disease ◽

Alcohol Dependence ◽

Alcoholic Liver Disease ◽

Therapeutic Potential ◽

Scattered Data ◽

Peroxisome Proliferator ◽

Liver Pathology ◽

Ppar Agonists ◽

Peroxisome Proliferator Activated Receptors

The article is aimed to summarize the scattered data on the role of peroxisome proliferator-activated receptors (PPAR) and the possibility of using PPAR’s agonists for treatment of alcohol dependence and alcoholic liver disease. Earlier it was shown that some PPAR agonists can reduce ethanol consumption and preference in rodents. Several hypotheses considering the antialcoholic activity of PPAR agonists and the roles of PPAR in the development of alcohol dependence were discussed. In light of these data, the therapeutic potential of PPARs agonists as an agent for the treatment of alcoholism, has been reviewed.

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Intestinal dysbiosis and permeability: the yin and yang in alcohol dependence and alcoholic liver disease

Clinical Science ◽

10.1042/cs20171055 ◽

2018 ◽

Vol 132 (2) ◽

pp. 199-212 ◽

Cited By ~ 35

Author(s):

Peter Stärkel ◽

Sophie Leclercq ◽

Philippe de Timary ◽

Bernd Schnabl

Keyword(s):

Liver Disease ◽

Alcohol Dependence ◽

Alcoholic Liver Disease ◽

Drinking Behavior ◽

Intestinal Barrier ◽

Public Health Problem ◽

Current Evidence ◽

Major Public Health Problem ◽

Chronic Alcohol ◽

Chronic Alcohol Abuse

Alcohol dependence and alcoholic liver disease represent a major public health problem with substantial morbidity and mortality. By yet incompletely understood mechanisms, chronic alcohol abuse is associated with increased intestinal permeability and alterations of the gut microbiota composition, allowing bacterial components, bacteria, and metabolites to reach the portal and the systemic circulation. These gut-derived bacterial products are recognized by immune cells circulating in the blood or residing in remote organs such as the liver leading to the release of pro-inflammatory cytokines which are considered important mediators of the liver–gut–brain communication. Although circulating cytokines are likely not the sole factors involved, they can induce liver inflammation/damage and reach the central nervous system where they favor neuroinflammation which is associated with change in mood, cognition, and drinking behavior. In this review, the authors focus on the current evidence describing the changes that occur in the intestinal microbiota with chronic alcohol consumption in conjunction with intestinal barrier breakdown and inflammatory changes sustaining the concept of a gut–liver–brain axis in the pathophysiology of alcohol dependence and alcoholic liver disease.

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