Abstract
Background: Previous studies have shown that p53 gene is expressed in muscle invasive bladder cancer (MIBC) , but the relationship between p53 gene and prognosis of muscle invasive bladder tumor is controversial. Methods: Download p53 gene expression profiles and clinical data of 412 cases bladder cancer from the Cancer Genome Atlas (TCGA) database on c-BioPortal website, and analyze their relationship. Carrying on mutation and survival analysis with c-BioPortal tools. Results: ① Among 412 cases, 207 cases had mutations, including 161 cases missense mutations and 68 cases truncation mutations. Among them, 22 cases had both missense and truncation mutations, and 1 case had frameshift mutation, with high incidence of mutations.② Expression of p53 was negatively correlated with TNM stage, distant metastasis, lymph node metastasis and clinical stage for studying objects (P<0.05) , and positively correlated with lymphatic infiltration and pathological stage (P<0.05) .There was no correlation between p53 expression and mutation (P>0.05) . ③ There was no significant difference between expression and mutation of p53 and total survival and disease-free survival of bladder cancer patients (P>0.05) . ④ Cox multivariate analysis of p53 expression and prognosis of bladder cancer indicated, lymph node metastasis and infiltration of bladder cancer, distant metastasis of bladder cancer was independent adverse factors of bladder cancer prognosis (P<0.05) , and p53 expression and mutation in bladder cancer was not independent factors affecting prognosis of bladder cancer. Conclusion: Although p53 has a high mutation rate in myometrial invasive bladder cancer, there is no clear difference in survival and disease-free survival period, and it can not be considered that p53 mutation can affect the prognosis of myometrial invasive bladder cancer.
Pd-L1 Expression in Muscle-Invasive Bladder Cancer Cystectomy Specimens and Lymph Node Metastasis