Prognostic value of signet ring cell histology for survival in stage I and II colon cancer patients: a population-based, propensity score matched analysis

Peritumoral budding and intratumoral budding (ITB) are important prognostic factors for colorectal cancer patients. Scientists worldwide have investigated the role of budding in tumor progression and its prognosis, but guidelines for reliably identifying tumor buds based on morphology are lacking. In this study, next-generation tissue microarray (ngTMA®) construction was used for tumor bud evaluation, and highly detailed rule-out annotation was used for tumor definition in pancytokeratin-stained tissue sections. Initially, tissues of 245 colon cancer patients were evaluated with high interobserver reliability, and a concordance of 96% was achieved. It was shown that high ITB scores were associated with poor distant metastasis-free survival (p = 0.006 with a cut-off of ≥10 buds). This cut-off was defined as the best maximum value from one of two/three ngTMA® cores (0.6 mm diameter). ITB in 30 cases of mucinous, medullary, and signet ring cell carcinoma was analyzed for the subsequent determination of differences in tumor bud analyses between those subtypes. In conclusion, blinded randomized punched cores in the tumor center can be useful for ITB detection. It can be assumed that this method is suitable for its adoption in clinical routines.

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Preoperative Systemic Immune-Inflammation Index (SII) for Predicting the Survival of Patients with Stage I-III Gastric Cancer with a Signet-Ring Cell (SRC) Component

BioMed Research International ◽

10.1155/2020/5038217 ◽

2020 ◽

Vol 2020 ◽

pp. 1-11

Author(s):

Ziyu Zhu ◽

Xiliang Cong ◽

Rui Li ◽

Xin Yin ◽

Chunfeng Li ◽

...

Keyword(s):

Gastric Cancer ◽

Cancer Patients ◽

Prognostic Value ◽

Curative Resection ◽

Signet Ring Cell ◽

Study Cohort ◽

Signet Ring ◽

Ring Cell ◽

Immune Inflammation ◽

Gastric Cancer Patients

Background. Recently, a novel systemic immune-inflammation index (SII) based on peripheral lymphocytes, neutrophils, and platelets has been reported to be correlated with patient prognosis in several malignancies, including gastric cancer. However, the prognostic value of the SII for gastric cancer patients with a signet-ring cell (SRC) component has not yet been reported. In this study, we aimed to assess the prognostic value of the SII in gastric cancer patients with an SRC component after curative resection. Methods. This study was a retrospective analysis of 512 GC patients with an SRC component who underwent curative resection. The prognostic value of the SII was analyzed by the Kaplan-Meier method and Cox proportional hazards regression model. Results. In our study cohort, an optimal cut-off value for the SII of 527 was used to stratify patients with gastric cancer (GC) into low (<527) and high SII (≥527) groups. Our study indicated that a high SII (≥527) was significantly correlated with a large tumor size (p<0.001), infiltration of serosa (p<0.001), lymph node metastasis (p<0.001), and advanced TNM stage (p<0.001). Univariate and multivariate analyses further demonstrated that a low SII was correlated with better clinical outcome and was an independent prognostic predictor in GC patients with an SRC component. Furthermore, the SII retained prognostic value in the subgroup analysis, including subgroup of different TNM stages and pure or mixed signet-ring cell carcinomas (SRCCs). Conclusion. The SII is a simple, promising, and practical prognostic biomarker for patients with surgically resected mixed SRCC and pure SRCC. The SII could complement current prognostic tools for better treatment planning and stratification of patients.

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Poorer prognosis for neuroendocrine carcinoma than signet ring cell cancer of the colon and rectum (CRC-NEC): a propensity score matching analysis of patients from the Surveillance, Epidemiology, and End Results (SEER) database

International Journal of Colorectal Disease ◽

10.1007/s00384-020-03809-2 ◽

2021 ◽

Author(s):

Youwei Chen ◽

Jiangfeng Tu ◽

Shishi Zhou ◽

Jianfei Fu ◽

Qinghua Wang

Keyword(s):

Propensity Score ◽

Propensity Score Matching ◽

Neuroendocrine Carcinoma ◽

Cell Cancer ◽

Signet Ring Cell ◽

Seer Database ◽

Propensity Score Matching Analysis ◽

Signet Ring ◽

Colon And Rectum ◽

Ring Cell

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Evaluation of Traditional Prognostic Factors for Stage I-III Colorectal Cancer Patients Who Survived for Over Five Years After Surgery

Frontiers in Oncology ◽

10.3389/fonc.2021.618820 ◽

2021 ◽

Vol 11 ◽

Author(s):

Dakui Luo ◽

Yufei Yang ◽

Zezhi Shan ◽

Qi Liu ◽

Sanjun Cai ◽

...

Keyword(s):

Vascular Invasion ◽

Perineural Invasion ◽

Cox Regression ◽

Signet Ring Cell ◽

Stage I ◽

Regression Analyses ◽

Pathological Stage ◽

Entire Cohort ◽

Signet Ring ◽

Ring Cell

The aim of this study was to explore the prognostic factors in stage I-III colorectal cancer (CRC) patients who had survived for over five years. A total of 9754 stage I-III CRC patients who received curative surgery in the Department of Colorectal Surgery, Fudan University Shanghai Cancer Center were enrolled in this study. Of them, 3640 patients had survived for over five years after surgery. Univariate and multivariate Cox regression analyses were performed in the entire cohort and those who had survived for over five years. Compared with patients in the entire cohort, patients who had survived for over five years were more likely to be younger, have less disease of signet ring cell histology, perineural invasion and vascular invasion, more well differentiated tumors and stage I disease. In the entire cohort, increased age, signet ring cell, poor differentiation, more advanced pathological stage, perineural invasion and vascular invasion were inversely associated with disease-free survival (DFS) and overall survival (OS) using multivariable Cox regression analyses. Only age, pathological stage and perineural invasion remained significant in patients who had survived for over five years. Moreover, tumor location was an independent factor for OS in this subgroup. Predictors for prognosis of CRC change over time. Age, pathological stage and perineural invasion deserve more attention among patients who have survived for over five years.

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