scholarly journals Comparison of immune microenvironment between different neoadjuvant radiotherapy regimens for rectal cancer

2018 ◽  
Vol 29 ◽  
pp. viii168-viii169
Author(s):  
J. Wu ◽  
Q. Peng ◽  
J. Li ◽  
L. Tang ◽  
Y. Huang ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Immune Microenvironment ◽  
Neoadjuvant Radiotherapy

Surgery, Radio- and Chemo- therapy for Multimodal Treatment of Rectal Cancer

Swiss Surgery ◽  
2001 ◽  
Vol 7 (6) ◽  
pp. 256-274 ◽  
Author(s):  
Link ◽  
Staib ◽  
Kornmann ◽  
Formentini ◽  
Schatz ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Multimodal Treatment ◽  
Local Relapse ◽  
Phase Iii ◽  
Neoadjuvant Radiotherapy ◽  
Term Survival ◽  
Primary Tumors ◽  
Impact On Survival ◽  
Relapse Rates

The possibilities and results of multimodal treatment in rectal cancer were reviewed with respect to the results of surgical treatment only. Based on the results of 4 studies, reducing local relapse rates and increasing long term survival rates significantly, postoperative radiochemotherapy (RCT) + chemotherapy (CT) should remain the recommended standard for R0 resected UICC II and III rectal cancers. The addition of RT to adjuvant CT reduces local relapses without significant impact on survival (NSABP R-02). Vice versa, the addition of CT to RT or an improved CT in the RCT-concept prolongs survival. Preoperative neoadjuvant radiotherapy (RT) reduced local relapse rates in 9 studies, and extended survival in one study that evaluated all eligible patients. Preoperative RT reduced local relapse rates in addition to total mesorectal excision (TME) but did not extend survival. The preoperative RCT + CT downstages resectable and nonresectable tumors and induces a higher sphincter preservation rate. Phase III data justifying its routine use in all UICC II + III stages are not yet available. This treatment may be routinely applied in nonresectable primary tumors or local relapses. Preoperative RCT (or RT) may evolve as standard, if the patient selection is improved and postoperative morbidity and long term toxicity reduced. Intraoperative RT could be added to this concept or be used together with preoperative/postoperative RT at the same indications. Postoperative adjuvant RT reduced local relapses significantly in a single trial, and no impact on survival time is reported. Since postoperative RT is inferior to preoperative RT, this treatment cannot be recommended, if RT is chosen as a single treatment modality in adjunction to surgery. The results of local tumor excisions may be improved with pre- or postoperative RCT + CT. In the future, multimodal treatment of rectal cancer might be more effective, if individualized according to prognostic factors.

VEGFA and PlGF Protein Signature of Primary Stage IV Rectal Cancer Pre and Post Neoadjuvant Radiotherapy, Bevacizumab, and Chemotherapy

2015 ◽  
Vol 3 (3) ◽  
pp. 164-173
Author(s):  
Karin Tamas ◽  
Tonnis H. van Dijk ◽  
Urszula M. Domanska ◽  
Hetty Timmer-Bosscha ◽  
Klaas Havenga ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Stage Iv ◽  
Neoadjuvant Radiotherapy ◽  
Primary Stage ◽  
Protein Signature

scholarly journals EP-1463: Phase II study of adaptive high-dose neoadjuvant radiotherapy in high risk rectal cancer

2018 ◽  
Vol 127 ◽  
pp. S794-S795
Author(s):  
A. Guido ◽  
L. Giaccherini ◽  
L. Fuccio ◽  
S. Fanti ◽  
D. Cuicchi ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
High Risk ◽  
Phase Ii ◽  
Phase Ii Study ◽  
High Dose ◽  
Neoadjuvant Radiotherapy

Neoadjuvant Radiotherapy Versus Surgery Alone for Stage II/III Mid-low Rectal Cancer With or Without High-risk Factors

2019 ◽  
Vol 272 (6) ◽  
pp. 1060-1069 ◽  
Author(s):  
Xiangbing Deng ◽  
Ping Liu ◽  
Dan Jiang ◽  
Mingtian Wei ◽  
Xin Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Rectal Cancer ◽  
High Risk ◽  
Low Rectal Cancer ◽  
Stage Ii ◽  
Neoadjuvant Radiotherapy ◽  
High Risk Factors

scholarly journals Recurrent Intestinal Obstruction after Radiation Therapy: A Case Report and Review of the Literature

2019 ◽  
Vol 2019 ◽  
pp. 1-3
Author(s):  
James Nguyen ◽  
Amani Jambhekar ◽  
Ziyad Nasrawi ◽  
Prasad Gudavalli
Keyword(s):  
Rectal Cancer ◽  
Case Report ◽  
Small Bowel ◽  
Intestinal Obstruction ◽  
Loop Ileostomy ◽  
Neoadjuvant Chemoradiation ◽  
Ileocolic Anastomosis ◽  
Neoadjuvant Radiotherapy ◽  
Diverting Loop Ileostomy ◽  
Radiation Induced

Introduction. In patients who have undergone resection for rectal cancer after neoadjuvant radiotherapy, loop ileostomy is commonly performed with few serious complications. In rare cases, if this irradiated small bowel is strictured, reversal of the affected ileostomy can have dire consequences. We present a case of a 62-year-old male with recurrent intestinal obstruction after closure of his loop ileostomy. Case Report. RC is a 62-year-old male who initially presented with rectal cancer and underwent neoadjuvant chemoradiation prior to a laparoscopic low anterior resection with diverting loop ileostomy. He underwent elective reversal of his ileostomy and developed persistent postoperative obstruction. He underwent resection of the prior reversal site with normal-appearing dilated proximal bowel loops and collapsed distal bowel loops. He again developed an obstructive picture and underwent resection of the prior anastomosis with creation of an ileocolic anastomosis, after which he recovered well postoperatively. Conclusion. In patients who receive radiation adjuvant therapy for colon cancer, radiation-induced stricture should be considered as a cause of small bowel obstruction postoperative. In the setting of a longstanding ileostomy, evaluation of a defunctionalized distal ileum may be necessary to evaluate potential obstruction from radiation changes.

scholarly journals Association of systemic and local inflammation with prognosis in rectal cancer treated with neoadjuvant radiotherapy

2018 ◽  
Vol 29 ◽  
pp. viii169
Author(s):  
J. Li ◽  
X. Zhang ◽  
Y. Huang ◽  
L. Tang ◽  
Q. Peng ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Local Inflammation ◽  
Neoadjuvant Radiotherapy
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