scholarly journals Inference of cellular level signaling networks using single-cell gene expression data in C. elegans reveals mechanisms of cell fate specification

2016 ◽  
pp. btw796
Author(s):  
Xiao-Tai Huang ◽  
Yuan Zhu ◽  
Leanne Lai Hang Chan ◽  
Zhongying Zhao ◽  
Hong Yan
Keyword(s):  
Gene Expression ◽  
Cell Fate ◽  
Cellular Level ◽  
Signaling Networks ◽  
Expression Data ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
C Elegans ◽  
Cell Gene Expression ◽  
Cell Gene

scholarly journals Analysis of Cell Fate from Single-Cell Gene Expression Profiles in C. elegans

Cell ◽  
2009 ◽  
Vol 139 (3) ◽  
pp. 623-633 ◽  
Author(s):  
Xiao Liu ◽  
Fuhui Long ◽  
Hanchuan Peng ◽  
Sarah J. Aerni ◽  
Min Jiang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Single Cell ◽  
Cell Fate ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
C Elegans ◽  
Cell Gene Expression ◽  
Cell Gene

scholarly journals GiniClust: detecting rare cell types from single-cell gene expression data with Gini index

2016 ◽  
Vol 17 (1) ◽  
Author(s):  
Lan Jiang ◽  
Huidong Chen ◽  
Luca Pinello ◽  
Guo-Cheng Yuan
Keyword(s):  
Gene Expression ◽  
Single Cell ◽  
Gene Expression Data ◽  
Gini Index ◽  
Cell Types ◽  
Expression Data ◽  
Cell Gene Expression ◽  
Cell Gene

scholarly journals Resolution of Cell Fate Decisions Revealed by Single-Cell Gene Expression Analysis from Zygote to Blastocyst

2010 ◽  
Vol 18 (4) ◽  
pp. 675-685 ◽  
Author(s):  
Guoji Guo ◽  
Mikael Huss ◽  
Guo Qing Tong ◽  
Chaoyang Wang ◽  
Li Li Sun ◽  
...  
Keyword(s):  
Gene Expression ◽  
Single Cell ◽  
Cell Fate ◽  
Expression Analysis ◽  
Gene Expression Analysis ◽  
Cell Fate Decisions ◽  
Cell Gene Expression ◽  
Cell Gene

Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development

Development ◽  
1993 ◽  
Vol 117 (2) ◽  
pp. 493-507 ◽  
Author(s):  
P.J. Kooh ◽  
R.G. Fehon ◽  
M.A. Muskavitch
Keyword(s):  
Cell Fate ◽  
Delta Function ◽  
Cellular Level ◽  
Cellular Interactions ◽  
Cell Fate Specification ◽  
Drosophila Development ◽  
Fate Specification ◽  
Endocytic Vesicles ◽  
Derivatives Of ◽  
Subcellular Level

Delta and Notch function are required for cell fate specification in numerous tissues during embryonic and postembryonic Drosophila development. Delta is expressed by all members of interacting cell populations within which fates are being specified and is subsequently down-regulated as cells stably adopt particular fates. Multiphasic expression in the derivatives of many germ layers implies successive requirements for Delta function in a number of tissues. At the cellular level, Delta and Notch expression are generally coincident within developing tissues. At the subcellular level, Delta and Notch are localized in apparent endocytic vesicles during down-regulation from the surfaces of interacting cells, implying an interaction consistent with their proposed roles as signal and receptor in cellular interactions during development.

Genes necessary for C. elegans cell and growth cone migrations

Development ◽  
1997 ◽  
Vol 124 (9) ◽  
pp. 1831-1843 ◽  
Author(s):  
W.C. Forrester ◽  
G. Garriga
Keyword(s):  
Cell Fate ◽  
Single Gene ◽  
Growth Cones ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
C Elegans ◽  
Final Destination ◽  
Multiple Cell

The migrations of cells and growth cones contribute to form and pattern during metazoan development. To study the mechanisms that regulate cell motility, we have screened for C. elegans mutants defective in the posteriorly directed migrations of the canal-associated neurons (CANs). Here we describe 14 genes necessary for CAN cell migration. Our characterization of the mutants has led to three conclusions. First, the mutations define three gene classes: genes necessary for cell fate specification, genes necessary for multiple cell migrations and a single gene necessary for final positioning of migrating cells. Second, cell interactions between the CAN and HSN, a neuron that migrates anteriorly to a position adjacent to the CAN, control the final destination of the HSN cell body. Third, C. elegans larval development requires the CANs. In the absence of CAN function, larvae arrest development, with excess fluid accumulating in their pseudocoeloms. This phenotype may reflect a role of the CANs in osmoregulation.

scholarly journals Putative cell type discovery from single-cell gene expression data

2020 ◽  
Vol 17 (6) ◽  
pp. 621-628 ◽  
Author(s):  
Zhichao Miao ◽  
Pablo Moreno ◽  
Ni Huang ◽  
Irene Papatheodorou ◽  
Alvis Brazma ◽  
...  
Keyword(s):  
Gene Expression ◽  
Single Cell ◽  
Gene Expression Data ◽  
Expression Data ◽  
Cell Type ◽  
Cell Gene Expression ◽  
Cell Gene
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