scholarly journals 1594 Invasive Ductal Carcinoma with Osteoclast Giant Cells During Pregnancy: A Case Report and A Review of Literature

2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
H Abdulrahman ◽  
D Johnston ◽  
S Diab ◽  
B Skelly
Keyword(s):  
Invasive Ductal Carcinoma ◽  
English Language ◽  
Ductal Carcinoma ◽  
Histological Finding ◽  
Immunohistochemical Analysis ◽  
Giant Cells ◽  
Axillary Metastasis ◽  
Rare Tumour ◽  
First Case ◽  
Epidemiological Characteristics

Abstract Mammary carcinoma with Osteoclast Giant Cells (OGCs) is a rare tumour. Although several cases were reported, the significance of this histological finding remains incompletely understood. OGCs may occur in several types of breast carcinoma with different epidemiological characteristics but, in association with pregnancy, OGCs has not been reported to date. Here we report a case 37-year-old presenting with a symptomatic breast lump in pregnancy that has been confirmed clinically and radiologically. Microscopic examination of biopsies and surgical specimens showed OGCs accompanying invasive ductal carcinoma with no evidence of axillary metastasis. Immunohistochemical analysis revealed tumour cells to be positive for oestrogen, and progesterone receptors, with human epidermal growth factor negative status (ER6, PR8, HER2 negative). This is the first case of OGCs during pregnancy to be reported, to our best of knowledge, following a search of the literature published in English language.

The First Case of HER2+ Invasive Ductal Carcinoma Arising From a Breast Hamartoma and Literature Review

2017 ◽  
Vol 109 (1) ◽  
pp. 55-59
Author(s):  
Lea Baer ◽  
Sherise Chantell Rogers ◽  
Patricia Farrelly ◽  
Carmen Tornos ◽  
Keith Sweeney
Keyword(s):  
Literature Review ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
First Case ◽  
Breast Hamartoma

Invasive Ductal Carcinoma with Osteoclastic Giant Cells of Breast: Clinicopathologic Characteristics

2013 ◽  
Vol 19 (3) ◽  
pp. 329-330 ◽  
Author(s):  
Yi-Ling Yang ◽  
Yu Fan ◽  
Rong-Gang Lang ◽  
Xiu-Min Ding ◽  
Xin-Min Zhang ◽  
...  
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Giant Cells ◽  
Clinicopathologic Characteristics

scholarly journals Isolated Uterine Metastasis of Invasive Ductal Carcinoma

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Deniz Arslan ◽  
Deniz Tural ◽  
Ali Murat Tatlı ◽  
Emre Akar ◽  
Mükremin Uysal ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Lobular Carcinoma ◽  
Metastatic Breast ◽  
Radical Mastectomy ◽  
Total Abdominal Hysterectomy ◽  
Breast Disease ◽  
Pathological Examination ◽  
First Case

Introduction. Most common metastasis sites of breast cancer are the lungs, bones, liver, and brain, whereas uterine involvement by metastatic breast disease is rare. Metastatic carcinoma of the uterus usually originates from other genital sites, most commonly being from the ovaries. Invasive lobular carcinoma spreads to gynecologic organs more frequently than invasive ductal carcinoma.Case Report. A 57-year-old postmenopausal woman was diagnosed with breast carcinoma 2 years ago and modified radical mastectomy was performed. Pathological examination of tumor revealed invasive ductal carcinoma, stage IIIc. She presented with abdominal pain and distension. Diagnostic workup and gynecologic examination revealed lesions that caused diffuse thickening of the uterus wall. Endometrial sampling was performed for confirmation of the diagnosis. She underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy. Breast carcinoma metastases in endometrium and myometrium were confirmed histopathologically and immunohistochemically.Conclusion. We herein report the first case of isolated uterine patient who had invasive ductal carcinoma of breast.

scholarly journals Ductal carcinoma in situ of the breast with osteoclast-like giant cells: A case report with immunohistochemical analysis

2020 ◽  
Vol 20 ◽  
pp. 200383
Author(s):  
Tsengelmaa Jamiyan ◽  
Hajime Kuroda ◽  
Mitsuhiro Hayashi ◽  
Akihito Abe ◽  
Ken Shimizu ◽  
...  
Keyword(s):  
Case Report ◽  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Immunohistochemical Analysis ◽  
Giant Cells

scholarly journals Invasive ductal carcinoma: relationship between pathological characteristics and the presence of axillary metastasis in 220 cases

2017 ◽  
Vol 44 (2) ◽  
pp. 163-170 ◽  
Author(s):  
RANNIERE GURGEL FURTADO DE AQUINO ◽  
PAULO HENRIQUE DIÓGENES VASQUES ◽  
DIANE ISABELLE MAGNO CAVALCANTE ◽  
AYANE LAYNE DE SOUSA OLIVEIRA ◽  
BRUNO MASATO KITAGAWA DE OLIVEIRA ◽  
...  
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Radical Mastectomy ◽  
Homogeneous Distribution ◽  
Tumor Diameter ◽  
Breast Cancer Patients ◽  
Axillary Metastases ◽  
Axillary Metastasis ◽  
Cross Sectional ◽  
Angiolymphatic Invasion

ABSTRACT Objective: to analyze the relation of anatomopathological features and axillary involvement in cases of invasive ductal carcinoma. Methods: this is a cross-sectional study of 220 breast cancer patients submitted to radical mastectomy or quadrantectomy with axilar emptying, from the Mastology Service of the Assis Chateaubriand Maternity School, Ceará, Brazil. We submitted the tumors to histological processing and determined the histological (HG), tubular (TG) and nuclear (NG) grades, and the mitotic index (MI) by the classification of Scarff-Bloom-Richadson, verified the presence of angiolymphatic invasion (AI) and measured the largest tumor diameter (TD). We then correlated these variables with the presence of axillary metastases. Results: the mean patients'age was 56.81 years ± 13.28. Tumor size ranged from 0.13 to 22 cm, with an average of 2.23cm ± 2.79. HG3, TG3 and NG3 prevailed, respectively 107 (48.6%), 160 (72.7%) and 107 (48.6%). Mitotic indexes 1, 2 and 3 presented a homogeneous distribution, respectively 82 (37.2%), 68 (31%) and 70 (31.8%). We observed no relation between the HG, TG and NG with the occurrence of axillary metastases (p=0.07, p=0.22 and p=0.21, respectively). Mitotic indices 2 and 3 were related with the occurrence of axillary metastases (p=0.03). Tumors larger than 2cm and cases that presented angiolymphatic invasion had a higher index of axillary metastases (p=0.0003 and p<0.0001). Conclusion: elevated mitotic indexes, tumors with a diameter greater than 2cm and the presence of angiolymphatic invasion were individuallyassociatedwith the occurrence of axillary metastases.

scholarly journals Apocrine Breast Carcinoma - Pathohistological And Immunohistochemical Analysis, Prognosis and Complex Treatment

2021 ◽  
Vol 6 (2) ◽  
Keyword(s):  
Breast Cancer ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Progesterone Receptors ◽  
Immunohistochemical Analysis ◽  
Axillary Lymph ◽  
Complex Treatment ◽  
Receptor Profile ◽  
Muscle Fascia ◽  
Breast Preserving Surgery

Apocrine breast cancer (ABC) is a rarely diagnosed pathomorphological subtype of invasive ductal carcinoma of the breast. We present a clinical case of apocrine breast cancer in a 36-year-old woman. A left-sided breast-preserving surgery (quadrantectomy am blok with underlying muscle fascia) and axillary lymph dissection at all three levels were performed. The complex treatment is continued with adjuvant chemotherapy, followed by radiotherapy of the left mammary gland. The pathomorphological and immunohistochemical characteristics of apocrine breast cancer, the prognosis and the necessary complex treatment are discussed. Immunohistochemical (IHC) analysis of apocrine carcinoma cells reported a characteristic steroid receptor profile with negative IHC expression for estrogen and progesterone receptors and positive for androgen receptors. ABC is prognostically similar to invasive ductal carcinoma / NOS. Apocrine breast cancer needs to be classified as a separate nosological unit, due to growing evidence of a different hormonal profile with different clinical behavior following androgen deprivation therapy.

scholarly journals Breast cancer with choriocarcinomatous and neuroendocrine features

2001 ◽  
Vol 119 (4) ◽  
pp. 154-155 ◽  
Author(s):  
Osvaldo Giannotti Filho ◽  
Luciana Nakao Odashiro Miiji ◽  
Marta Vainchenker ◽  
Ângela Navarro Gordan
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Giant Cells ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Axillary Lymph ◽  
Brazilian Woman ◽  
The Right

CONTEXT: Breast cancer may express the presence of b-human chorionic gonadotrophin in 12% to 18% of cases, using immunohistochemical reactions. Usually the tumors will show positivity in a few scattered cells. Breast cancer with choriocarcinomatous features, as reported by Saigo and Rosen, is a distinct variant of breast cancer. We report a case of breast cancer with choriocarcinomatous and neuroendocrine features. OBJECTIVE: This is a case report of an invasive ductal carcinoma of the breast with choriocarcinomatous and neuroendocrine features. DESIGN: Case Report. CASE REPORT: A 50-year-old Brazilian woman underwent surgery for a lump in the right breast, which had been first noticed about 3 months earlier. The surgery consisted of quadrantectomy followed by right mastectomy with ipsilateral axillary lymph node dissection. The specimen from the quadrantectomy revealed a 7 x 6.5 x 4.5 cm tumor. Histology of the lesion showed the presence of an invasive ductal carcinoma with areas of giant cells and intense atypia. The immunohistochemistry was positive in the pleomorphic areas for human chorionic gonadotrophin, while the less pleomorphic areas showed positivity for synaptophysin and chromogranin.

Colocalized Granular Cell Tumor and Infiltrating Ductal Carcinoma of the Breast

2002 ◽  
Vol 126 (6) ◽  
pp. 731-733 ◽  
Author(s):  
Hikmat Al-Ahmadie ◽  
Per-Olof Hasselgren ◽  
Rawia Yassin ◽  
George Mutema
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Granular Cell Tumor ◽  
Ductal Carcinoma ◽  
Granular Cell ◽  
Cell Tumor ◽  
Palpable Mass ◽  
First Case ◽  
History Of ◽  
Well Differentiated ◽  
The Right

Abstract A 57-year-old woman presented with a 2-year history of a palpable mass in the upper inner quadrant of the right breast. A 1.1-cm, poorly circumscribed, firm tumor nodule was noted, consisting of 2 histologically distinct lesions in the same location, with some areas showing purely well-differentiated invasive ductal carcinoma and others composed of granular cell tumor. In 1 area, the 2 tumors collided and infiltrated each other. The invasive ductal carcinoma was admixed with ductal carcinoma in situ of solid and cribriform types. To our knowledge, this is the first case report demonstrating colocalization of these 2 neoplasms, which raises questions regarding causal relationship. We also review the literature on granular cell tumor of the breast.

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