scholarly journals 1000 Basal-Squamous Cell Carcinoma Collision Tumour Of the Preauricular Region

2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
G Hallett ◽  
A Holden ◽  
S Colbert

Abstract Collision tumours are defined as multiple neoplasms adjacent to each other or combined in one area and are particularly rare, with only one other basal-squamous cell carcinoma combination of the head and neck region published in the literature. Case description An 87-year-old farmer presented to the Maxillofacial Surgery department following referral by his general practitioner concerned with multiple suspected skin neoplasms. Four lesions were identified, two of which required surgical excision with 4mm margins. Following histological investigation, the lesion in the right preauricular area was identified as a basal-squamous cell carcinoma collision tumour which was completely excised with clear margins. Discussion This case highlights the possibility of multiple skin neoplasms in a single site and gives an insight into the surgical management of a basal-squamous cell carcinoma collision tumour while aiming to increase clinician awareness of collision tumours especially in high-risk sites such as the head and neck. This case suggests that a 4-5mm surgical margin may be sufficient in removing similar presentations of basal-squamous cell carcinoma collision tumours however highlights the importance of appropriate histological examination of specimens not only to correctly diagnose the tumour but to ensure surgical margins are clear to mitigate recurrence risk. It must be noted that systemic metastases are more common in squamous cell carcinoma than in basal cell carcinoma cases and therefore it is possible that basal-squamous cell carcinoma collision tumours may have higher rates of metastases than traditional basal cell carcinomas.

2021 ◽  
pp. 912-917
Author(s):  
Zainub Ajmal ◽  
Abdul Moiz Khan ◽  
Lezah McCarthy ◽  
Allison Lupinetti ◽  
Syed Mehdi

Leiomyosarcoma (LMS) of the trachea is an extremely rare malignancy with only a few reported cases in English literature. As such the diagnosis can be frequently missed or delayed. We present a case of a 69-year-old male who underwent tracheostomy for airway obstruction secondary to glottic squamous cell carcinoma and treated definitely with radiation therapy. Subsequently, the patient developed LMS of the tracheostomy site. The case further details multiple risk factors that could contribute to development of LMS including radiation exposure, prior malignancy, and chronic inflammation. These risk factors have been well established for LMS in other sites but less so in the head and neck region, which is the subject of our discussion. We also review the current guidelines for head and neck as well as limb sarcomas and discussed role of surgery or radiation and their accompanying challenges in management of this rare malignancy.


1996 ◽  
Vol 105 (5) ◽  
pp. 409-413 ◽  
Author(s):  
Alfio Ferlito ◽  
Kenneth O. Devaney ◽  
Christopher M. Milroy ◽  
Alessandra Rinaldo ◽  
Antonino Carbone

Adenoid squamous cell carcinoma is an uncommon variant of squamous cell carcinoma. The lesion is histologically distinctive and it is usually localized on the skin of the head and neck region; it only rarely involves the mucosal sites. The differential diagnoses include adenosquamous carcinoma, adenoid cystic carcinoma, mucoepidermoid carcinoma, basaloid squamous cell carcinoma, and metastatic adenocarcinoma. Surgery is the treatment of choice. The biologic behavior of this neoplasm is more aggressive when it involves mucosal areas, and the prognosis seems worse than that of conventional squamous cell carcinoma.


2018 ◽  
Vol 7 (1) ◽  
pp. 165 ◽  
Author(s):  
M Sabzijate ◽  
AH Khatibi ◽  
T Ghiasian ◽  
S Rahrotaban ◽  
E Rastegar ◽  
...  

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Seza Tetikkurt ◽  
Faruk Taş ◽  
Funda Emre ◽  
Şule Özsoy ◽  
Zeki Tolga Bilece

A 53-year-old man was admitted for tooth mobility. A mass was identified at the tooth base by CT. Histopathology of the excisional biopsy revealed a moderately differentiated squamous cell carcinoma. Many intact neutrophils were observed within the malignant cell cytoplasm. The patient underwent partial maxillectomy and bilateral neck dissection. Significant neutrophilic emperipolesis was detected in the resected material. Four tumor recurrences developed in the head and neck region during follow-up. Surgery and chemoradiotherapy was performed. The latest tumor recurrence occurred in the peripharyngeal and the posterior parotideal region. The patient was started on pembrolizumab therapy and nearly complete treatment response occurred. Pembrolizumab was discontinued due to the adrenal insufficiency and pulmonary tuberculosis that developed as a treatment side effect. Pembrolizumab was commenced again when tumor recurrence occurred. The patient is currently alive with ongoing pembrolizumab and antituberculous treatment. We present this case to remark the presence of a significant neutrophilic emperipolesis in the squamous cell carcinoma of the hard palate and maxilla which is rarely encountered. Emperipolesis may predict tumor behavior and the consequences of immune-modulating treatment response in squamous cell carcinomas of the head and neck in regard to the findings of our case.


Author(s):  
Pedro Henrique Isaacsson Velho ◽  
Gilberto Castro ◽  
Christine H. Chung

Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease arising from the mucosal epithelia in the head and neck region. The most common risk factors are tobacco use, alcohol consumption, and HPV infection, particularly in the oropharynx. The HPV-positive HNSCC is biologically and clinically distinct from the HPV-negative HNSCC; however, deregulations within the phosphatidylinositol 3-kinase (PI3K) pathway are frequent in both HPV-positive and HPV-negative HNSCC as it is the most frequently altered oncogenic pathway with a gain-of-function in HNSCC. This article reviews the basic biology and clinical data from the trials involving anticancer agents targeting the PI3K pathway in HNSCC. It also discusses the difficulties of translating the preclinical data to tangible clinical efficacy of these agents in patients with HNSCC even when there is significant preclinical data suggesting the PI3K pathway is a promising therapeutic target in HNSCC. We conclude that additional studies to determine appropriate patient selection for the activation of PI3K pathway and to develop targeted agents either as a monotherapy or combination therapy with favorable toxicity profiles are required before a broader clinical application.


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