scholarly journals Induction of adenocarcinoma from hamster pancreatic islet cells treated with N-nitrosobis(2-oxopropyl)amine in vitro

1999 ◽  
Vol 20 (2) ◽  
pp. 317-324 ◽  
Author(s):  
B. Schmied
Diabetes ◽  
1996 ◽  
Vol 45 (9) ◽  
pp. 1197-1203 ◽  
Author(s):  
J. Saldeen ◽  
D. T. Curiel ◽  
D. L. Eizirik ◽  
A. Andersson ◽  
E. Strandell ◽  
...  

2002 ◽  
Vol 25 (5) ◽  
pp. 436-441 ◽  
Author(s):  
F. J. Tinahones ◽  
A. Pareja ◽  
F. J. Soriguer ◽  
J. M. Gómez-Zumaquero ◽  
F. Cardona ◽  
...  

2013 ◽  
Vol 228 (7) ◽  
pp. 1568-1576 ◽  
Author(s):  
Tamara Saksida ◽  
Ivana Nikolic ◽  
Milica Vujicic ◽  
Ulf J. Nilsson ◽  
Hakon Leffler ◽  
...  

2007 ◽  
Vol 236 (8) ◽  
pp. 2039-2049 ◽  
Author(s):  
Dongxuan Jia ◽  
Daniel Dajusta ◽  
Ramsey A. Foty

2008 ◽  
Vol 69 (9) ◽  
pp. 543-551 ◽  
Author(s):  
Peter D. Campbell ◽  
Eugene Estella ◽  
Nadine L. Dudek ◽  
Gaurang Jhala ◽  
Helen E. Thomas ◽  
...  

2022 ◽  
Vol 8 ◽  
Author(s):  
Yuhua Gao ◽  
Weijun Guan ◽  
Chunyu Bai

In this study, we isolated and cultured pancreatic ductal cells from canines and revealed the possibility for using them to differentiate into functional pancreatic beta cells in vitro. Passaged pancreatic ductal cells were induced to differentiate into beta-like pancreatic islet cells using a mixture of induced factors. Differentiated pancreatic ductal cells were analyzed based on intracellular insulin granules using transmission electron microscopy, the expression of insulin and glucagon using immunofluorescence, and glucose-stimulated insulin secretion using ELISA. Our data revealed that differentiated pancreatic ductal cells not only expressed insulin and glucagon but also synthesized insulin granules and secreted insulin at different glucose concentrations. Our study might assist in the development of effective cell therapies for the treatment of type 1 diabetes mellitus in dogs.


1998 ◽  
Vol 66 (5) ◽  
pp. 633-638 ◽  
Author(s):  
Anne-Sophie Rivereau ◽  
Sylvaine You ◽  
Sandrine Lalain ◽  
Edouard Gouin ◽  
Pierre Sa??

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