Clinical evaluation of Eastman Kodak's Ektachem 400 Analyzer.

1983 ◽  
Vol 29 (3) ◽  
pp. 498-501 ◽  
Author(s):  
C L Kadinger ◽  
R T O'Kell
Keyword(s):  
Carbon Dioxide ◽  
Clinical Trial ◽  
Computer System ◽  
Clinical Evaluation ◽  
Preventive Maintenance ◽  
Storage Space ◽  
Component Design ◽  
Modular Component ◽  
Potentiometric Tests

Abstract We evaluated the performance of the Kodak Ektachem 400 Analyzer in a 16-week clinical trial. We assessed four potentiometric tests and nine colorimetric tests for precision and correlation with results obtained some other commonly used instruments (Technicon SMA II and C800 System, Du Pont aca II, and Baker CentrifiChem). The comparison was favorable for all tests except albumin, sodium, and carbon dioxide. The reagents are stable. Little refrigerator storage space is needed. The computer system and the modular component design of the Ektachem 400 Analyzer make operation, troubleshooting, and preventive maintenance relatively easy.

A Controlled Clinical Trial of Local Anesthesia for Lumbar Punctures in Newborns

PEDIATRICS ◽  
1991 ◽  
Vol 88 (4) ◽  
pp. 663-669 ◽  
Author(s):  
Fran L. Porter ◽  
J. Philip Miller ◽  
F. Sessions Cole ◽  
Richard E. Marshall
Keyword(s):  
Carbon Dioxide ◽  
Clinical Trial ◽  
Heart Rate ◽  
Lumbar Puncture ◽  
Local Anesthesia ◽  
Subcutaneous Administration ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Transcutaneous Oxygen ◽  
Experimental Group

To evaluate the efficacy of subcutaneous administration of lidocaine for reducing physiologic instability in acutely ill newborns during clinically required procedures, 81 neonates who required lumbar punctures within the first month of life were stratified by birth weight and respiratory support and randomly assigned to an experimental or a control group. The experimental group received an injection of 0.1 mL/kg of 1% lidocaine prior to the lumbar puncture. The control group received a nonanesthetized lumbar puncture without placebo. Changes in heart rate, respiratory rate, transcutaneous oxygen and carbon dioxide tensions, and heart rate variability from baseline, preparatory (positioning/handling), lumbar puncture, and recovery periods were measured. The administration of lidocaine did not minimize physiologic instability in response to the lumbar puncture nor was it associated with any detectable adverse effects other than prolonging the duration of the lumbar puncture. Although significant physiologic changes were observed in response to preparatory procedures, few additional changes beyond those occurred in response to lumbar punctures in either the experimental or control group. It is concluded that local anesthesia failed to influence manifestations of physiologic instability during neonatal lumbar punctures and that preparatory procedures were more destabilizing than either the administration of lidocaine or the lumbar puncture itself. The results suggest that the management of newborns requires emphasis on minimizing the destabilizing effects of required and frequent handling procedures.

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