scholarly journals Optical fiber fluoroprobes in clinical analysis.

1983 ◽  
Vol 29 (9) ◽  
pp. 1678-1682 ◽  
Author(s):  
M J Sepaniak ◽  
B J Tromberg ◽  
J F Eastham

Abstract We used quartz optical fibers and laser excitation in developing single-fiber fluoroprobes, to be used to measure molecular fluorescence in minute volumes of body fluids. We illustrate and discuss the analytical capabilities of these fluoroprobes. Limits of detection for the anti-tumor drug doxorubicin are about 10(-7) mol/L, by either conventional fluorescence or sequentially excited fluoroscence modes of detection. We also report the results of preliminary in vivo measurements of doxorubicin in the interstitial fluids of human tumors, heterotransplanted in immune-deficient laboratory mice.

Sensors ◽  
2020 ◽  
Vol 20 (2) ◽  
pp. 511
Author(s):  
Cloé Desmet ◽  
Karim Vindas ◽  
Ricardo Alvarado Meza ◽  
Patrick Garrigue ◽  
Silvia Voci ◽  
...  

The development of sensitive methods for in situ detection of biomarkers is a real challenge to bring medical diagnosis a step forward. The proof-of-concept of a remote multiplexed biomolecular interaction detection through a plasmonic optical fiber bundle is demonstrated here. The strategy relies on a fiber optic biosensor designed from a 300 µm diameter bundle composed of 6000 individual optical fibers. When appropriately etched and metallized, each optical fiber exhibits specific plasmonic properties. The surface plasmon resonance phenomenon occurring at the surface of each fiber enables to measure biomolecular interactions, through the changes of the retro-reflected light intensity due to light/plasmon coupling variations. The functionalization of the microstructured bundle by multiple protein probes was performed using new polymeric 3D-printed microcantilevers. Such soft cantilevers allow for immobilizing the probes in micro spots, without damaging the optical microstructures nor the gold layer. We show here the potential of this device to perform the multiplexed detection of two different antibodies with limits of detection down to a few tenths of nanomoles per liter. This tool, adapted for multiparametric, real-time, and label free monitoring is minimally invasive and could then provide a useful platform for in vivo targeted molecular analysis.


Lab on a Chip ◽  
2019 ◽  
Vol 19 (12) ◽  
pp. 2060-2070 ◽  
Author(s):  
Mohamed Elsherif ◽  
Rosalia Moreddu ◽  
Muhammad Umair Hassan ◽  
Ali K. Yetisen ◽  
Haider Butt

The applications of optical fibers are impeded in implantable medical diagnostics due to incompatibility with biological tissues, and immune reaction in vivo.


2012 ◽  
Vol E95.B (8) ◽  
pp. 2638-2641 ◽  
Author(s):  
Makoto YAMADA ◽  
Akisumi TOMOE ◽  
Takahiro KINOSHITA ◽  
Osanori KOYAMA ◽  
Yutaka KATUYAMA ◽  
...  
Keyword(s):  

2021 ◽  
Vol 11 (7) ◽  
pp. 3254
Author(s):  
Marco Pisco ◽  
Francesco Galeotti

The realization of advanced optical fiber probes demands the integration of materials and structures on optical fibers with micro- and nanoscale definition. Although researchers often choose complex nanofabrication tools to implement their designs, the migration from proof-of-principle devices to mass production lab-on-fiber devices requires the development of sustainable and reliable technology for cost-effective production. To make it possible, continuous efforts are devoted to applying bottom-up nanofabrication based on self-assembly to decorate the optical fiber with highly ordered photonic structures. The main challenges still pertain to “order” attainment and the limited number of implementable geometries. In this review, we try to shed light on the importance of self-assembled ordered patterns for lab-on-fiber technology. After a brief presentation of the light manipulation possibilities concerned with ordered structures, and of the new prospects offered by aperiodically ordered structures, we briefly recall how the bottom-up approach can be applied to create ordered patterns on the optical fiber. Then, we present un-attempted methodologies, which can enlarge the set of achievable structures, and can potentially improve the yielding rate in finely ordered self-assembled optical fiber probes by eliminating undesired defects and increasing the order by post-processing treatments. Finally, we discuss the available tools to quantify the degree of order in the obtained photonic structures, by suggesting the use of key performance figures of merit in order to systematically evaluate to what extent the pattern is really “ordered”. We hope such a collection of articles and discussion herein could inspire new directions and hint at best practices to fully exploit the benefits inherent to self-organization phenomena leading to ordered systems.


2011 ◽  
Vol 32 (11) ◽  
pp. 1017-1022 ◽  
Author(s):  
Masamitsu Kido ◽  
Kazuya Ikoma ◽  
Kan Imai ◽  
Masahiro Maki ◽  
Ryota Takatori ◽  
...  

Background: The objective of this study was to evaluate the bone rotation of each joint in the hindfoot and compare the load response in healthy feet with that in flatfeet by analyzing the reconstructive three-dimensional (3D) CT image data during weightbearing. Methods: CT scans of 21 healthy feet and 21 feet with flatfoot deformity were taken in non-load condition followed by full-body weightbearing load condition. The images of the hindfoot bones were reconstructed into 3D models. The volume merge method in three planes was used to calculate the position of the talus relative to the tibia in the tibiotalar joint, the navicular relative to the talus in talonavicular joint, and the calcaneus relative to the talus in the talocalcaneal joint. Results: The talar position difference to the load response relative to the tibia in the tibiotalar joint in a flatfoot was 1.7 degrees more plantarflexed in comparison to that in a healthy foot ( p = 0.031). The navicular position difference to the load response relative to the talus in the talonavicular joint was 2.3 degrees more everted ( p = 0.0034). The calcaneal position difference to the load response relative to the talus in the talocalcaneal joint was 1.1 degrees more dorsiflexed ( p = 0.0060) and 1.7 degrees more everted ( p = 0.0018). Conclusion: Referring to previous cadaver study, regarding not only the cadaveric foot, but also the live foot, joint instability occurred in the hindfoot with load in patients with flatfoot. Clinical Relevance: The method used in this study might be applied to clinical analysis of foot diseases such as the staging of flatfoot and to biomechanical analysis to evaluate the effects of foot surgery in the future. Level of Evidence: III


Author(s):  
Yih-Tun Tseng ◽  
Jhong-Bin Huang ◽  
Che-Hsin Lin ◽  
Chin-Lung Chen ◽  
Wood-Hi Cheng

The GI (graded-index) POFs (Plastic optical fibers), which has been proven to reach distances as long as 1 km at 1.25 Gb/s has a relatively low numerical aperture . Therefore, the efficient coupling of GI POFs to the light source has become critical to the power budget in the system. Efficient coupling for a POFs system normally involves either a separate lens or the direct formation of the lens at the end of the fiber. Forming the lens-like structure directly on the fiber end is preferred for simplicity of fabrication and packaging, such as polishing and fusion, combine different fibers with the cascaded fiber method and hydroflouride (HF) chemical etching. These approaches are well established, but applicable only to glass. Optical assembly architecture for multichannel fibers and optical devices is critical to optical fiber interconnections. Multichannel fiber-pigtail laser diode (LD) modules have potential for supporting higher data throughput and longer transmission distances. However, to be of practical use, these modules must be more precise. This work proposes and manufactures lensed plastic optical fibers (LPOF) array. This novel manipulation can be utilized to fabricate an aspherical lens on a fiber array after the UV curing of the photo-sensitive polymer; the coupling efficiency (CE) is increased and exceeds 47% between the LD array and the fiber array.


Talanta ◽  
1983 ◽  
Vol 30 (2) ◽  
pp. 121-123 ◽  
Author(s):  
J. Wang ◽  
L.D. Hutchins ◽  
S. Selim ◽  
L.B. Cumming

Micromachines ◽  
2018 ◽  
Vol 9 (10) ◽  
pp. 521 ◽  
Author(s):  
Georgia Konstantinou ◽  
Karolina Milenko ◽  
Kyriaki Kosma ◽  
Stavros Pissadakis

We demonstrate a three-port, light guiding and routing T-shaped configuration based on the combination of whispering gallery modes (WGMs) and micro-structured optical fibers (MOFs). This system includes a single mode optical fiber taper (SOFT), a slightly tapered MOF and a BaTiO3 microsphere for efficient light coupling and routing between these two optical fibers. The BaTiO3 glass microsphere is semi-immersed into one of the hollow capillaries of the MOF taper, while the single mode optical fiber taper is placed perpendicularly to the latter and in contact with the equatorial region of the microsphere. Experimental results are presented for different excitation and reading conditions through the WGM microspherical resonator, namely, through single mode optical fiber taper or the MOF. The experimental results indicate that light coupling between the MOF and the single mode optical fiber taper is facilitated at specific wavelengths, supported by the light localization characteristics of the BaTiO3 glass microsphere, with spectral Q-factors varying between 4.5 × 103 and 6.1 × 103, depending on the port and parity excitation.


2017 ◽  
Author(s):  
Karim Vindas ◽  
Elodie Engel ◽  
Patrick Garrigue ◽  
Thierry Livache ◽  
Stéphane Arbault ◽  
...  

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