Determination of volatile alcohols and acetone in serum by non-polar capillary gas chromatography after direct sample injection.

1984 ◽  
Vol 30 (10) ◽  
pp. 1672-1674 ◽  
Author(s):  
N B Smith
Keyword(s):  
Gas Chromatography ◽  
Capillary Gas Chromatography ◽  
Capillary Column ◽  
Internal Standard ◽  
Fused Silica ◽  
Gas Chromatograph ◽  
Ionization Detector ◽  
Flame Ionization ◽  
Split Ratio

Abstract In this method for detection and quantification of volatile alcohols by capillary gas chromatography, the serum sample is deproteinized, then directly injected into the gas chromatograph with 1-propanol as the internal standard. The capillary column is a 30-m bonded methylsilicone-coated, fused-silica column. With helium as the carrier gas, the injector inlet is set at a split ratio of 1/30 and the average linear velocity in the column is 25 cm/s. Injector and flame-ionization detector temperatures are 280 degrees C, oven temperature 35 degrees C. Chromatography time is less than 3 min.

Determination of Trifluralin in Formulations by Gas Chromatography

1971 ◽  
Vol 54 (1) ◽  
pp. 125-127
Author(s):  
Larry G Hambleton
Keyword(s):  
Gas Chromatography ◽  
Chromatographic Method ◽  
Internal Standard ◽  
Flame Ionization Detector ◽  
Gas Chromatograph ◽  
Ionization Detector ◽  
Average Recovery ◽  
Flame Ionization ◽  
Gas Chromatographic Method

Abstract A gas chromatographic method has been developed that is rapid and specific for trifluralin in formulations. The sample is extracted with acetone, an internal standard is added, and the solution is diluted to volume and injected into a gas chromatograph equipped with a flame ionization detector. Three typical trifluralin formulations were analyzed by both the gas chromatographic method and an ultraviolet method. The gas chromatographic method gave an average recovery of 101.2%.

scholarly journals Determination of N-Nitrosodimethylamine in the Smoke of High-Nitrate Tobacco Cigarettes

1973 ◽  
Vol 7 (2) ◽  
Author(s):  
G.P. Morie ◽  
C.H. Sloan
Keyword(s):  
Capillary Column ◽  
Glass Capillary Column ◽  
Gas Chromatograph ◽  
Ionization Detector ◽  
Glass Capillary ◽  
Flame Ionization ◽  
Basic Solutions ◽  
Poly Ethylene ◽  
Gas Chromatographic Method

AbstractA gas chromatographic method was developed for the determination of N-nitrosodimethylamine (NDMA) in cigarette smoke. The NDMA in the smoke of 200 cigarettes was trapped in a solution of sodium hydroxide and separated from most of the smoke components by distillation from acidic and basic solutions. The aqueous solution was extracted for 8 hr. into ethyl ether in a Dean Stark apparatus. To concentrate the solution of NDMA, the ether was distilled until only 5 ml of the solution remained. An aliquot of this solution was analysed by means of a gas chromatograph equipped with a 200-ft. glass capillary column coated with Carbowax 20-M poly(ethylene glycoI). An alkali metal flame ionization detector with a selectivity of 10*/1 for nitrogen compounds to normal hydrocarbons was used. Small amounts (2 ng) of nitrosamines in the presence of large amounts of other compounds were easily detected. N-nitrosodimethylamine-C

scholarly journals Determination of Residues of Eight Synthetic Pyrethroids in Tobacco by Capillary Gas Chromatography

1994 ◽  
Vol 16 (2) ◽  
pp. 65-75
Author(s):  
BS Dattilo ◽  
S Gallo ◽  
G Lionetti
Keyword(s):  
Gas Chromatography ◽  
Film Thickness ◽  
Stationary Phase ◽  
Capillary Gas Chromatography ◽  
Capillary Column ◽  
Limit Of Detection ◽  
Synthetic Pyrethroids ◽  
Gas Chromatograph ◽  
Limit Of Determination

AbstractA method was developed for the simultaneous determination of the residues of the following eight synthetic pyrethroids and their isomers in tobacco: tetramethrin, permethrin, cyfluthrin, cypermethrin, alfamethrin, flucythrinate, fluvalinate and deltamethrin. The pesticides were extracted from ground tobacco by means of acetone:water 9:1 for 5 hours. The extract was diluted with water and partitioned into n-hexane. The organic phase was concentrated to about 1 ml and then purified by a Florisil-SPE column. The gas-chromatographic analyses were run with a gas-chromatograph Carlo Erba Series Mega HRGC 5300 equipped with a capillary column (stationary phase OV-1 - 0.10-0.15 µm film thickness, 25 m long) and a 63Ni electron-capture detector. Two different injection ports were used: split-splitless and cold split-splitless, working both with isothermal and programmed temperatures. Both the limit of detection and the limit of determination were estimated for each compound. Recoveries from fortified samples at level of 1 µgKg-1 are reported.

Direct Blood-Injection Method for Gas Chromatographic Determination of Alcohols and Other Volatile Compounds

1971 ◽  
Vol 17 (2) ◽  
pp. 82-85 ◽  
Author(s):  
Naresh C Jain
Keyword(s):  
Sample Preparation ◽  
Volatile Compounds ◽  
Low Cost ◽  
Internal Standard ◽  
Chromatographic Determination ◽  
Gas Chromatograph ◽  
Ionization Detector ◽  
Flame Ionization ◽  
Blood Injection

Abstract An extremely simple, rapid method is described for simultaneously determining methanol, ethanol, acetone, isopropanol, and low-boiling hydrocarbons associated with glue sniffing. Less than 1 µl of blood, mixed with an internal standard, is injected directly into a low-cost gas chromatograph equipped with a flame-ionization detector. No extraction, distillation, and (or) sample preparation is required, and the method is sensitive to less than 10 µg of alcohol per ml.

scholarly journals Simple and Sensitive Methods for the Determination of 2-(4′-Chloromethyl phenyl) Benzonitrile and 2-(4′-Bromomethyl phenyl) Benzonitrile Contents in Valsartan Drug Substance by Gas Chromatography

2013 ◽  
Vol 2013 ◽  
pp. 1-5
Author(s):  
G. Amarnatha Reddy ◽  
K. Hussain Reddy ◽  
M. Narendra Kumar ◽  
Hemant kumar Sharma
Keyword(s):  
Gas Chromatography ◽  
Stationary Phase ◽  
Particle Diameter ◽  
Internal Standard ◽  
Drug Substance ◽  
Ionization Detector ◽  
Chromatographic Separations ◽  
Flame Ionization ◽  
Dimethyl Polysiloxane

Simple and reliable gas chromatographic methods were developed, optimized, and validated for the determination of 2-(4′-chloromethyl phenyl) benzonitrile (2-CMPB) and 2-(4′-bromomethyl phenyl) benzonitrile (2-BMPB) contents in valsartan drug substance, using benzophenone as internal standard (IS). Efficient chromatographic separations were achieved on DB-1, 30 m length with 0.53 mm i.d., and 3 μm particle diameter column consists of 100% dimethyl polysiloxane as a stationary phase by passing helium as a carrier gas. The analytes were extracted in dichloromethane and monitored by flame ionization detector. The performance of these methods was assessed by evaluating specificity, precision, sensitivity, linearity, and accuracy. The limits of detection (LOD) and limits of quantification (LOQ) established for 2-CMPB are 0.10 μg mL−1 and 0.32 μg mL−1, respectively. For 2-BMPB, LOD is 0.31 μg mL−1 and LOQ is 0.95 μg mL−1. The average recoveries for 2-CMPB are in the range of 96.8% to 106.7% and for 2-BMPB (LOQ level) are 99.3%. The methods can be successfully applied for the routine analysis of valsartan drug substance.

scholarly journals A novel method of furan determination in beer using gas chromatography with a flame ionization detector

2019 ◽  
Vol 65 (6) ◽  
Author(s):  
Jana Olšovská ◽  
Tomáš Horák ◽  
Karel Štěrba
Keyword(s):  
Gas Chromatography ◽  
Capillary Column ◽  
Flame Ionization Detector ◽  
Ionization Detector ◽  
Carcinogenic Effect ◽  
Flame Ionization ◽  
Space Technique ◽  
Novel Method ◽  
Inner Diameter

Furan is considered to have a potential carcinogenic effect on human health. Its presence was found in a number of foods including beer. Thus, it is necessary to have a fast and routine method for its determination. This study describes a procedure meeting these requirements using the head-space technique associated with gas chromatography. A capillary column with the length of 60 m, inner diameter of 0.32 mm and the film thickness of 0.25 μm was used for the determination of furan. A flame-ionization detector (FID) was used for the detection. The characteristics of the procedure are presented.

Gas Chromatographic Determination of Phosphamidon Insecticide in Formulations

1972 ◽  
Vol 55 (6) ◽  
pp. 1331-1335 ◽  
Author(s):  
A A Carlstrom
Keyword(s):  
Coefficient Of Variation ◽  
Internal Standard ◽  
Chromatographic Determination ◽  
Flame Ionization Detector ◽  
Gas Chromatograph ◽  
Ionization Detector ◽  
Flame Ionization ◽  
Wide Range ◽  
Peak Areas

Abstract The GLC method described is specific for measuring 4 components of Phosphamidon Insecticide—deschlorophosphamidon, α-phosphamidon, β-phosphamidon, and γ-chlorophosphamidon. The sample is extracted with acetone, an internal standard (dicyclohexyl phthalate) is added, and the solution is diluted to volume and injected into a gas chromatograph equipped with a flame ionization detector. Although the GLC peak areas for phosphamidon are not linear over a wide range of concentration, good results are obtained when sample and standard concentrations are matched to within 10%. A 1.21% coefficient of variation was found for 19 repetitive injections.

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