Lentil-lectin-reactive alpha-fetoprotein in the differential diagnosis of benign and malignant liver disease.

Abstract Affinity chromatography of serum on lentil lectin bound to Sepharose 4B has been used to identify different forms of alpha-fetoprotein in serum of patients with liver disease. We studied eight patients with non-malignant liver disease, finding that 7-15% of the serum alpha-fetoprotein bound to the lectin. In contrast, for 15 patients with malignant liver disease, 25-83% of the serum alpha-fetoprotein bound to the lectin. Evidently, this simple technique can be used effectively to differentiate these two conditions.

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Alpha-fetoprotein: Immunochemical Purification and Chemical Properties. Expression in Normal State and in Malignant and non-Malignant Liver Disease

Immunological Reviews ◽

10.1111/j.1600-065x.1974.tb00140.x ◽

1974 ◽

Vol 20 (1) ◽

pp. 38-60 ◽

Cited By ~ 2

Author(s):

Erkki Ruoslahti ◽

Helena Pihko ◽

Markku Seppala

Keyword(s):

Liver Disease ◽

Normal State ◽

Chemical Properties ◽

Alpha Fetoprotein ◽

Malignant Liver Disease ◽

Malignant Liver ◽

And Chemical Properties

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A Study to Access the Correlation between Serum Alpha Fetoprotein and Radiological Image Finding in Patients with Malignant Liver Mass

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11i4.3311 ◽

2020 ◽

Vol 11 (4) ◽

pp. 6282-6285

Author(s):

Annamalai T T ◽

Yuvaraj Muralidharan

Keyword(s):

Hepatocellular Carcinoma ◽

Liver Disease ◽

Age Groups ◽

Cross Sectional Study ◽

Alpha Fetoprotein ◽

Liver Mass ◽

Cross Sectional ◽

Major Health Problem ◽

Malignant Liver Disease ◽

Malignant Liver

Malignant liver mass remains a major health problem worldwide. Patients with chronic liver disease, the accuracy of ultrasound scan (US), spiral computed tomography (CT), magnetic resonance imaging (MRI), and alpha-fetoprotein (AFP) in diagnosing hepatocellular carcinoma (HCC) and malignant liver disease is assessed in this study. This study helps to find out the significance of serum alpha protein in patients with malignant liver mass. Retrospective cross-sectional study was done on patients with malignant liver mass. A total of 62 patients were diagnosed with malignant liver mass, out of which 44 are male, and 18 were female. They were grouped into three age groups 30-50 years, 51-70 years and above 70 years. In this study, out of the radiologically diagnosed malignant liver mass, HPE has proven hepatocellular carcinoma where 67.7% and liver secondaries where 29.03%. 55% of malignant liver mass has raised alpha feto proteins. 74% of HCC diagnosed and confirmed on biopsy have elevated alpha feto proteins. Only 11% of multiple malignant liver lesions have elevated alpha feto proteins.AFP receptors are expressed only in the AFP-positive HCC tissues. In the AFP-negative HCC, the rate of tumour growth would probably be expected to be relatively slow, and tumour staging might be lower than in AFP-positive. Based on this study, radiological imaging has been very useful in the diagnosis of various malignant liver masses in both elevated and normal AFP.

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Small proline rich protein 2a in benign and malignant liver disease

Hepatology ◽

10.1002/hep.26889 ◽

2014 ◽

Vol 59 (3) ◽

pp. 1130-1143 ◽

Cited By ~ 15

Author(s):

Yoshiaki Mizuguchi ◽

Kumiko Isse ◽

Susan Specht ◽

John G. Lunz ◽

Natasha Corbitt ◽

...

Keyword(s):

Liver Disease ◽

Malignant Liver Disease ◽

Malignant Liver ◽

Small Proline Rich Protein ◽

Proline Rich Protein

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Affinity chromatography used in distinguishing alpha-fetoprotein in serum from patients with tumors of hepatic parenchyma and of germ cells.

Clinical Chemistry ◽

10.1093/clinchem/30.7.1257 ◽

1984 ◽

Vol 30 (7) ◽

pp. 1257-1258 ◽

Cited By ~ 9

Author(s):

P K Buamah ◽

C Cornell ◽

A W Skillen

Keyword(s):

Germ Cell ◽

Affinity Chromatography ◽

Germ Cells ◽

Concanavalin A ◽

Primary Liver Cancer ◽

Germ Cell Tumors ◽

Alpha Fetoprotein ◽

Hepatic Parenchyma ◽

Liver Cancers ◽

Serum Alpha Fetoprotein

Abstract We used affinity chromatography on concanavalin A Sepharose to study the serum alpha-fetoprotein of 10 patients with histologically proven germ-cell tumors and 12 patients with primary liver cancer. Less than 50% of the fetoprotein from germ-cell tumors bound to concanavalin A, as compared with more than 80% of the alpha-fetoprotein from primary liver cancers.

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