scholarly journals A Study to Access the Correlation between Serum Alpha Fetoprotein and Radiological Image Finding in Patients with Malignant Liver Mass

2020 ◽  
Vol 11 (4) ◽  
pp. 6282-6285
Author(s):  
Annamalai T T ◽  
Yuvaraj Muralidharan
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Disease ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Alpha Fetoprotein ◽  
Liver Mass ◽  
Cross Sectional ◽  
Major Health Problem ◽  
Malignant Liver Disease ◽  
Malignant Liver

Malignant liver mass remains a major health problem worldwide. Patients with chronic liver disease, the accuracy of ultrasound scan (US), spiral computed tomography (CT), magnetic resonance imaging (MRI), and alpha-fetoprotein (AFP) in diagnosing hepatocellular carcinoma (HCC) and malignant liver disease is assessed in this study. This study helps to find out the significance of serum alpha protein in patients with malignant liver mass. Retrospective cross-sectional study was done on patients with malignant liver mass. A total of 62 patients were diagnosed with malignant liver mass, out of which 44 are male, and 18 were female. They were grouped into three age groups 30-50 years, 51-70 years and above 70 years. In this study, out of the radiologically diagnosed malignant liver mass, HPE has proven hepatocellular carcinoma where 67.7% and liver secondaries where 29.03%. 55% of malignant liver mass has raised alpha feto proteins. 74% of HCC diagnosed and confirmed on biopsy have elevated alpha feto proteins. Only 11% of multiple malignant liver lesions have elevated alpha feto proteins.AFP receptors are expressed only in the AFP-positive HCC tissues. In the AFP-negative HCC, the rate of tumour growth would probably be expected to be relatively slow, and tumour staging might be lower than in AFP-positive. Based on this study, radiological imaging has been very useful in the diagnosis of various malignant liver masses in both elevated and normal AFP.

Lentil-lectin-reactive alpha-fetoprotein in the differential diagnosis of benign and malignant liver disease.

1986 ◽  
Vol 32 (11) ◽  
pp. 2083-2084 ◽  
Author(s):  
P K Buamah ◽  
R Harris ◽  
O F James ◽  
A W Skillen
Keyword(s):  
Differential Diagnosis ◽  
Liver Disease ◽  
Affinity Chromatography ◽  
Simple Technique ◽  
Alpha Fetoprotein ◽  
Lentil Lectin ◽  
Serum Alpha Fetoprotein ◽  
Malignant Liver Disease ◽  
Malignant Liver ◽  
Sepharose 4B

Abstract Affinity chromatography of serum on lentil lectin bound to Sepharose 4B has been used to identify different forms of alpha-fetoprotein in serum of patients with liver disease. We studied eight patients with non-malignant liver disease, finding that 7-15% of the serum alpha-fetoprotein bound to the lectin. In contrast, for 15 patients with malignant liver disease, 25-83% of the serum alpha-fetoprotein bound to the lectin. Evidently, this simple technique can be used effectively to differentiate these two conditions.

scholarly journals ALPHA FETOPROTEIN;

2017 ◽  
Vol 24 (05) ◽  
pp. 641-645
Author(s):  
Syed Muhammad Ali Shah ◽  
Zamir Butt ◽  
Muhammad Waqas
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Liver Disease ◽  
Screening Test ◽  
Abdominal Ultrasound ◽  
Alpha Fetoprotein ◽  
Screening Tests ◽  
Cross Sectional ◽  
Score Analysis ◽  
Chronic Hcv

BACKGROUND: Hepatocellular carcinoma (HCC) is a primary tumor of theliver, which develops in the setting of chronic liver disease, particularly in patients with chronichepatitis B and C in almost 80% patients. Although there are no specific screening tests fordiagnosis of HCC but alpha-fetoprotein (AFP) and abdominal ultrasound are commonly used.AFP >400 ng/ml is considered diagnostic for HCC. Objective: The objective of study wasto validate the use of alphafetoprotein as screening test for HCC due to chronic HCV. StudyDesign: Observational cross-sectional. Period: March 2014 to August 2016. Setting: AzizBhatti Shaheed Teaching Hospital Gujrat. Materials and Methods: 134 patients aged >35years having liver cirrhosis due to chronic HCV and diagnosed with HCC using biphasic CTscan were included and were followed for 1 year. Serum AFP was divided in 3 categories anda value < 20ng/ml - normal, 20-399 ng/ml - elevated and >400ng/ml - diagnostic of HCC.Liver nodules size and site was noted and divided in 4 categories. Severity of liver diseasewas calculated using Child Pugh Score. Analysis was done using SPSS 20.0. Results: AFP isdiagnostic (>400 ng/ml) in only 29.9% of patients with sensitivity of 43.3% at cut off value of400 ng/ml and is significantly associated with severity of liver disease. Conclusion: AFP cannotbe used as screening test for HCC in patients with cirrhosis due to chronic HCV. Abdominalultrasound should be used for early detection of HCC due to chronic hepatitis C.

scholarly journals Ambulatory end-stage liver disease in Ghana; patient profile and utility of alpha fetoprotein and aspartate aminotransferase: platelet ratio index

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yvonne Ayerki Nartey ◽  
Yaw Asante Awuku ◽  
Adwoa Agyei-Nkansah ◽  
Amoako Duah ◽  
Sally Afua Bampoh ◽  
...  
Keyword(s):  
Liver Disease ◽  
Aspartate Aminotransferase ◽  
Cross Sectional Study ◽  
Alpha Fetoprotein ◽  
Sub Saharan Africa ◽  
Teaching Hospitals ◽  
Cross Sectional ◽  
Patient Profile ◽  
End Stage Liver Disease ◽  
End Stage

Abstract Background End-stage liver disease (ESLD) is a major burden on public health, particularly in sub-Saharan Africa, where hepatitis B virus (HBV) is an important risk factor. We aimed to describe clinical characteristics of ESLD from cirrhosis or hepatocellular carcinoma (HCC) and the performance of aspartate aminotransferase (AST)—platelet ratio index (APRI) and alpha fetoprotein (AFP) in Ghana. Methods We performed an observational cross-sectional study in outpatient hepatology clinics at three teaching hospitals in Ghana, West Africa. One hundred and forty-one HCC, 216 cirrhosis and 218 chronic HBV patients were recruited by convenience sampling. Sociodemographic, history and examination, laboratory, and disease staging information were shown using descriptive statistics. Performance of the APRI score in diagnosis of cirrhosis and AFP in the diagnosis of HCC was determined using AUROC analysis. Results Median age at presentation was 44 years for HCC and 46 years for cirrhosis. HBV was found in 69.5% of HCC and 47.2% of cirrhosis cases, and HCV in 6.4% and 3.7% respectively. APRI cut-off of 2 had sensitivity of 45.4% and specificity of 95% in diagnosis of cirrhosis, and cut-off of 1 had sensitivity of 75.9% and specificity of 89%. AUC of AFP was 0.88 (95% CI 0.81–0.94) in diagnosis of HCC. Low monthly income was associated with lower odds of undertaking AFP. Thirty one percent of cirrhotic persons were Child–Pugh C, and 67.9% of HCC patients had advanced or terminal disease at presentation. Conclusions Our findings emphasize the young age of ESLD patients in Ghana and the advanced nature at presentation. It highlights shortcomings in surveillance and the need for policies to address the burden and improve outcomes in Ghana.

scholarly journals CORRELATION BETWEEN ALPHA FETOPROTEIN AND PLATELET PROFILE IN HEPATOCELLULAR CARCINOMA

2019 ◽  
Vol 26 (1) ◽  
pp. 87
Author(s):  
Rahmawati Rahmawati ◽  
Agus Alim Abdullah ◽  
Ibrahim Abdul Samad
Keyword(s):  
Hepatocellular Carcinoma ◽  
Platelet Count ◽  
Liver Damage ◽  
Tumor Size ◽  
Cross Sectional Study ◽  
T Test ◽  
Alpha Fetoprotein ◽  
Sectional Study ◽  
Chi Square ◽  
Cross Sectional

Hematology abnormalities are commonly found in Hepatocellular Carcinoma (HCC) patients. Platelet (PLT) count in HCC can be low, normal or high, and influenced by tumor and liver damage. There are limited studies about the correlationp between AFP and platelet profile of HCC in Indonesia, especially in Makassar. This study is aimed to analyze the correlation between AFP and platelet profile in HCC patients. A retrospective cross-sectional study was carried out from  January 2016 to June 2017 on 231 HCC subjects. The correlation between AFP and platelet profile, the correlation of AFP and platelet profile with the diagnosis were analyzed by Independent t-test and Chi-Square. There was no significant correlation between AFP and PLT profile and no significant correlation between AFP and HCC with and without cirrhosis with p>0.05 and p=0.094, respectively. Platelet count and PCT were significantly lower in cirrhotic HCC ompared to non-cirrhotic HCC (p<0.01, p<0.01, respectively), PDW and MPV were significantly higher in cirrhotic HCC compared to non-cirrhotic HCC  (p<0.05, p<0.05,  respectively). Mean platelet count and PCT in cirrhotic HCC were significantly lower compared to non- cirrhotic HCC, and mean PDW and MPV in cirrhotic HCC c were significantly higher compared to non-cirrhotic HCC. Further research was suggested to evaluate tumor size and nodules of HCC.

scholarly journals Prevalence of hypertension and associated risk factors among Bhutanese Monks in Thimphu, Bhutan: A cross-sectional study

2020 ◽  
pp. 28-31
Author(s):  
Kinley Bidha ◽  
Nazmul Alam
Keyword(s):  
Risk Factors ◽  
Prevalence Rate ◽  
Strong Association ◽  
Age Groups ◽  
Significant Risk ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Major Health Problem ◽  
Associated Risk Factors

Hypertension is a major health problem and it accounts for more than 9.4 million people to die every year globally due to its high complications. It is a major risk factor for cardiovascular diseases and high research importance has been given due to its high prevalence. The objective of the present study was to determine the prevalence of hypertension and to assess its risk factors among monks populations in Thimphu. A cross-sectional study with purposive sampling method was conducted among the five different monasteries in Thimphu. A self administered questionnaire was structured for 307 monks from age 18 and above. The prevalence rate of hypertension in the present study was 32.6% among Bhutanese monks. Hypertension is significantly higher in elder age groups which conclude that hypertension increase with the increase of age and have a strong association. Alcohol use, betel consumption, and physical inactivity were found to be significant risk factors for developing hypertension. With the 32.6% prevalence rate, only 26% of them are receiving medications. There is an impending need for effective intervention strategies.

scholarly journals Accuracy of Serum Golgi Protein 73 and Alpha Fetoprotein (AFP) to Diagnose Hepatocellular Carcinoma

2021 ◽  
Vol 8 (9) ◽  
pp. 468-473
Author(s):  
Karina Dwi Swastika ◽  
Gontar Alamsyah Siregar ◽  
Dharma Lindarto
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Cross Sectional Study ◽  
Alpha Fetoprotein ◽  
Control Group ◽  
Healthy Population ◽  
Sectional Study ◽  
Cross Sectional ◽  
Golgi Protein ◽  
Common Malignancy

Background: Hepatocellular Carcinoma (HCC) is one of the most common malignancy in the liver. Modalities of diagnostic are often an obstacle in HCC surveillance. Alpha fetoprotein (AFP) is one of protein that often used in the diagnostic of HCC in chronic liver disease. Golgi protein 73 (GP73), is one of the candidate biomarkers in early diagnostic of HCC and found in biliary epithelial cells but rarely expressed by normal hepatocytes. Expression of GP73 was reported to be increased in a large number of malignancies. Aims of this study to evaluate differences in Golgi protein 73 serum (sGP73) and AFP in diagnosing hepatocellular carcinoma in patients with liver cirrhosis. Materials and Methods: This cross-sectional study was conducted at Haji Adam Malik Hospital in 2020. Serum level of GP73 and others biomarker was detected using enzyme-like immunosorbent assay. Results: From 90 subjects, Liver cirrhosis and HCC group had significantly higher AFP than the control group. AFP was superior in determining HCC to GP73. At a cut off value of > 394.5.00 ng/mL, AFP yielded a sensitivity of 83.3% and specificity of 67%, for discriminating liver cirrhosis and HCC (AUC 0.84), while GP73 with cut off value of > 82.5 ng/mL, sensitivity of 70% and specificity of 57% (AUC 0.74). Conclusion:GP73 was significantly higher in HCC patients in comparison to non-HCC patients and healthy population. Compared with alpha fetoprotein, GP73 was superior in discriminating HCC in healthy population but inferior in group of liver cirrhosis. Keywords: Golgi Protein 73, Alpha Fetoprotein, Hepatocellular carcinoma.

The Effect of Benign and Malignant Liver Disease on the Tumour Markers CA19-9 and CEA

1998 ◽  
Vol 35 (1) ◽  
pp. 99-103 ◽  
Author(s):  
S Maestranzi ◽  
R Przemioslo ◽  
H Mitchell ◽  
R A Sherwood
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Liver Disease ◽  
Liver Dysfunction ◽  
Significant Proportion ◽  
Biliary Cirrhosis ◽  
Positive Correlations ◽  
Malignant Liver Disease ◽  
Malignant Liver ◽  
Benign Liver

The serum concentrations of CA19-9 and carcinoembryonic antigen (CEA) were measured in 150 consecutive patients with histologically proven liver disease admitted to a liver unit for transplant assessment. A significant proportion of the cases studied had a CA19-9 above the upper limit of the reference range (35 kU/L): alcoholic liver disease (73%), primary sclerosing cholangitis (61%), primary biliary cirrhosis (60%), chronic hepatitis B (71%), chronic hepatitis C (84%), autoimmune hepatitis (36%) and hepatocellular carcinoma (54%). CEA was only elevated in a small proportion of the patients with benign liver disease and the degree of elevation was small (15-37 μg/L). Significantly raised CEA was observed in two patients (15%) with hepatocellular carcinoma. Statistically significant correlations were observed between the serum CA19-9 concentration and standard parameters of liver dysfunction: positive correlations with aspartate aminotransferase, alkaline phosphatase and bilirubin and negative correlations with albumin and γ-glutamyltransferase. Positive relationships were also observed between CA19-9 and both CEA and creatinine. Both increased production of CA19-9 from biliary epithelial cells and decreased clearance due to cholestasis may be contributing to the elevation of CA19-9 in the bloodstream. Our data indicate that caution is needed in the interpretation of CA19-9 results in the presence of liver dysfunction.

scholarly journals Ambulatory end-stage liver disease in Ghana; patient profile and utility of alpha fetoprotein and aspartate aminotransferase - platelet ratio index.

2020 ◽  
Author(s):  
Yvonne Ayerki Nartey ◽  
Yaw Asante Awuku ◽  
Adwoa Agyei-Nkansah ◽  
Amoako Duah ◽  
Sally Afua Bampoh ◽  
...  
Keyword(s):  
Liver Disease ◽  
Aspartate Aminotransferase ◽  
Cross Sectional Study ◽  
Alpha Fetoprotein ◽  
Sub Saharan Africa ◽  
Teaching Hospitals ◽  
Cross Sectional ◽  
Patient Profile ◽  
End Stage Liver Disease ◽  
End Stage

Abstract Background: End-stage liver disease (ESLD) is a major burden on public health, particularly in sub-Saharan Africa, where hepatitis B virus (HBV) is an important risk factor. We aimed to describe clinical characteristics of ESLD from cirrhosis or hepatocellular carcinoma (HCC) and the performance of aspartate aminotransferase (AST) - platelet ratio index (APRI) and alpha fetoprotein (AFP) in Ghana. Methods: We performed an observational cross-sectional study in outpatient hepatology clinics at three teaching hospitals in Ghana, West Africa. One hundred and forty-one HCC, 216 cirrhosis and 218 chronic HBV patients were recruited by convenience sampling. Sociodemographic, history and examination, laboratory, and disease staging information were shown using descriptive statistics. Performance of the APRI score in diagnosis of cirrhosis and AFP in the diagnosis of HCC was determined using AUROC analysis.Results: Median age at presentation was 44 years for HCC and 46 years for cirrhosis. HBV was found in 69.5% of HCC and 47.2% of cirrhosis cases, and HCV in 6.4% and 3.7% respectively. APRI cut-off of 2 had sensitivity of 45.4% and specificity of 95% in diagnosis of cirrhosis, and cut-off of 1 had sensitivity of 75.9% and specificity of 89%. AUC of AFP was 0.88 (95% CI 0.81-0.94) in diagnosis of HCC. Low monthly income was associated with lower odds of undertaking AFP. Thirty one percent of cirrhotic persons were Child-Pugh C, and 67.9% of HCC patients had advanced or terminal disease at presentation. Conclusions: Our findings emphasize the young age of ESLD patients in Ghana and the advanced nature at presentation. It highlights shortcomings in surveillance and the need for policies to address the burden and improve outcomes in Ghana.

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