Electrophoretic mobility, concentration, and activity of alpha 1-antitrypsin in serum of patients undergoing bone-marrow transplantation.

1987 ◽  
Vol 33 (1) ◽  
pp. 193-195 ◽  
Author(s):  
R E Mullins ◽  
B Bennett ◽  
R L Hunter
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Aplastic Anemia ◽  
Electrophoretic Mobility ◽  
Functional Activity ◽  
Marrow Transplantation ◽  
Bone Marrow Transplants ◽  
Life Threatening ◽  
Alpha 1 Antitrypsin

Abstract We have observed an electrophoretically abnormal, nonfunctional species of alpha 1-antitrypsin in serum from patients who were receiving bone-marrow transplants for treatment of leukemia or aplastic anemia. Three of four patients in whose serum this protein appeared died soon after; the fourth recovered, and the disappearance of the abnormal alpha 1-antitrypsin paralleled his recovery. This suggests that the inability to maintain functional activity of alpha 1-antitrypsin predisposes patients to life-threatening complications during recovery from bone-marrow transplants.

scholarly journals Treatment of aplastic anemia by bone marrow transplantation in identical twins

Blood ◽  
1980 ◽  
Vol 55 (6) ◽  
pp. 1033-1039 ◽  
Author(s):  
FR Appelbaum ◽  
A Fefer ◽  
MA Cheever ◽  
JE Sanders ◽  
JW Singer ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Aplastic Anemia ◽  
Marrow Transplantation ◽  
Identical Twins

REGRESSION OF OXYMETHOLONE-INDUCED HEPATIC TUMORS AFTER BONE MARROW TRANSPLANTATION IN APLASTIC ANEMIA

1980 ◽  
Vol 30 (2) ◽  
pp. 90-96 ◽  
Author(s):  
ROBERT R. MONTGOMERY ◽  
JONATHAN M. DUCORE ◽  
JOHN H. GITHENS ◽  
CHARLES S. AUGUST ◽  
MICHAEL L. JOHNSON
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Aplastic Anemia ◽  
Marrow Transplantation ◽  
Hepatic Tumors

Survival and quality of life in 23 patients with severe aplastic anemia treated with bone marrow transplantation (BMT)

1987 ◽  
Vol 54 (3) ◽  
pp. 137-146 ◽  
Author(s):  
W. Hinterberger ◽  
H. Gadner ◽  
P. H�cker ◽  
A. Hajek-Rosenmayr ◽  
W. Graninger ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Aplastic Anemia ◽  
Marrow Transplantation ◽  
Severe Aplastic Anemia

scholarly journals Effect of natural killer cells on syngeneic bone marrow: in vitro and in vivo studies demonstrating graft failure due to NK cells in an identical twin treated by bone marrow transplantation

Blood ◽  
1985 ◽  
Vol 66 (5) ◽  
pp. 1043-1046
Author(s):  
GD Goss ◽  
MA Wittwer ◽  
WR Bezwoda ◽  
J Herman ◽  
A Rabson ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Aplastic Anemia ◽  
Nk Cells ◽  
Natural Killer ◽  
Marrow Transplantation ◽  
Bone Marrow Failure ◽  
Cell Activity ◽  
High Dose

Bone marrow transplantation for severe idiopathic aplastic anemia was undertaken in a patient, using his monozygotic twin brother as the donor. In spite of the use of syngeneic bone marrow, failure of engraftment occurred on two occasions. In vitro studies demonstrated that natural killer (NK) cells from the recipient markedly inhibited the growth of donor bone marrow granulocyte progenitor cells. On a third attempt, successful bone marrow engraftment was achieved following high-dose cyclophosphamide, which has previously been shown to be inhibitory to NK cells. We conclude that NK cell activity may play an important role in bone marrow failure as well as being responsible for at least some cases of aplastic anemia.

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