P125 Basement membrane remodelling as a biomarker for monitoring disease activity in Crohn’s disease patients: the role of laminin

Patients with Crohn’s disease, an inflammatory bowel disease, struggle with chronic somatic symptoms that could bring about emotional distress. This study assessed the relative role of somatization, and depressive and anxiety symptoms in disease activity among 619 Crohn’s patients (18–79 years; 58.3% women). Structural equation modeling revealed that somatization was the only unique predictor of disease activity beyond depression and anxiety. In addition, the effect of somatization on disease activity was stronger in men compared to women. Findings suggest that somatization represents a distinct domain of psychological distress that may play a role in the health of patients with Crohn’s disease.

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The Role of MR Enterography in Assessing Crohn’s Disease Activity and Treatment Response

Gastroenterology Research and Practice ◽

10.1155/2016/8168695 ◽

2016 ◽

Vol 2016 ◽

pp. 1-13 ◽

Cited By ~ 23

Author(s):

Matthew P. Moy ◽

Jenny Sauk ◽

Michael S. Gee

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Disease Activity ◽

Treatment Response ◽

Imaging Modality ◽

The United States ◽

Response To Therapy ◽

Mr Enterography ◽

Oral Contrast

MR enterography (MRE) has become the primary imaging modality in the assessment of Crohn’s disease (CD) in both children and adults at many institutions in the United States and worldwide, primarily due to its noninvasiveness, superior soft tissue contrast, and lack of ionizing radiation. MRE technique includes distention of the small bowel with oral contrast media with the acquisition of T2-weighted, balanced steady-state free precession, and multiphase T1-weighted fat suppressed gadolinium contrast-enhanced sequences. With the introduction of molecule-targeted biologic agents into the clinical setting for CD and their potential to reverse the inflammatory process, MRE is increasingly utilized to evaluate disease activity and response to therapy as an imaging complement to clinical indices or optical endoscopy. New and emerging MRE techniques, such as diffusion-weighted imaging (DWI), magnetization transfer, ultrasmall superparamagnetic iron oxide- (USPIO-) enhanced MRI, and PET-MR, offer the potential for an expanded role of MRI in detecting occult disease activity, evaluating early treatment response/resistance, and differentiating inflammatory from fibrotic strictures. Familiarity with MR enterography is essential for radiologists and gastroenterologists as the technique evolves and is further incorporated into the clinical management of CD.

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Role of biomarkers in diagnosis and evaluation of disease activity of Crohn’s disease

World Chinese Journal of Digestology ◽

10.11569/wcjd.v24.i32.4389 ◽

2016 ◽

Vol 24 (32) ◽

pp. 4389

Author(s):

Yi Zhang ◽

Pei-Xue Wang ◽

Hong-Jie Zhang

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Disease Activity

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Role of MR Enterography in Evaluation of Disease Activity in Pediatric Crohn’s Disease: Correlation between MR Enterography and Pediatric Crohn’s Disease Activity Index Scores

Journal of Gastrointestinal and Abdominal Radiology ◽

10.1055/s-0040-1701328 ◽

2020 ◽

Vol 03 (02) ◽

pp. 118-125

Author(s):

Shilpa Radhakrishnan ◽

Amarnath Chellathurai ◽

Srinivas Sankaranrayanan ◽

Dharani Sankar ◽

Suja Rajan

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Disease Activity ◽

Activity Index ◽

Disease Activity Index ◽

Mr Enterography ◽

Clinical Activity ◽

Positive Correlation

Abstract Objectives The aim of the study was to assess the role of MR Enterography (MRE) in the diagnosis and follow-up of children with Crohn’s disease (CD) and to correlate disease activity indices with known MRE features of active disease. Methods This was a retrospective study including 24 patients (median age 11 years, 17 males) with clinically and histologically proven CD who underwent MRE. Two previously validated MRE scores—Magnetic Resonance Enterography Global Score (MEGS) and CD MRI index (CDMI)—were calculated. A correlative analysis was made between the Pediatric Crohn’s Disease Activity Index (PCDAI) score and MRE scores as well as individually with each MR variable. Comparison of both the MR scores was made between patients with different disease activity. Results MEGS and PCDAI scores showed strong positive correlation (r = 0.724, p = < 0.001); CDMI and PCDAI scores showed moderate positive correlation (r = 0.661, p = 0.0004). There was statistically significant difference in the MR scores between patients grouped by clinical activity. Among individual MR variables, mural thickness and enhancement best predicted the disease activity. Conclusions MRE-based scores and findings correlate with clinical activity in pediatric CD. Thereby, MRE can be considered a valuable tool in the management of CD, predicting disease activity and offering a potential alternative to endoscopy in monitoring patients during follow-up.

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PO65 ROLE OF PARIS CLASSIFICATION AND OF THE PCDAI (PEDIATRIC CROHN'S DISEASE ACTIVITY INDEX) AT DIAGNOSIS AND FOR THE PROGNOSIS OF CHILDHOOD ONSET CROHN'S DISEASE

Digestive and Liver Disease ◽

10.1016/s1590-8658(12)60729-4 ◽

2012 ◽

Vol 44 ◽

pp. S285-S286

Author(s):

L. Garassino ◽

M. Baldi ◽

P.L. Calvo ◽

M. Surace ◽

D. Dell'Olio ◽

...

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Disease Activity ◽

Activity Index ◽

Disease Activity Index ◽

Childhood Onset ◽

Crohn’S Disease Activity ◽

Paris Classification

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Role of Doppler ultrasonography evaluation of superior mesenteric artery flow volume in the assessment of Crohn's disease activity

Radiologia Brasileira ◽

10.1590/s0100-39842013000500003 ◽

2013 ◽

Vol 46 (5) ◽

pp. 279-283 ◽

Cited By ~ 1

Author(s):

Fabiana Paiva Martins ◽

Eduardo Garcia Vilela ◽

Maria de Lourdes Abreu Ferrari ◽

Henrique Osvaldo da Gama Torres ◽

Juliana Brovini Leite ◽

...

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Disease Activity ◽

Superior Mesenteric Artery ◽

Mesenteric Artery ◽

Doppler Ultrasonography ◽

Flow Volume ◽

Crohn’S Disease Activity ◽

Artery Flow

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Crohn's disease activity assessed by doppler sonography: the role of aortic flow parameters

Clinics ◽

10.6061/clinics/2013(04)04 ◽

2013 ◽

Vol 68 (4) ◽

pp. 457-462 ◽

Cited By ~ 1

Author(s):

TG Andrade ◽

HS Fogaca ◽

CCS Elia ◽

MT Pitrowsky ◽

HSP Souza

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Disease Activity ◽

Doppler Sonography ◽

Aortic Flow ◽

Flow Parameters ◽

Crohn’S Disease Activity

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Intestinal Ultrasound in Inflammatory Bowel Disease: A Valuable and Increasingly Important Tool

GE Portuguese Journal of Gastroenterology ◽

10.1159/000520212 ◽

2021 ◽

pp. 1-17

Author(s):

Catarina Frias-Gomes ◽

Joana Torres ◽

Carolina Palmela

Keyword(s):

Ulcerative Colitis ◽

Inflammatory Bowel Disease ◽

Crohn’S Disease ◽

Crohn's Disease ◽

Disease Activity ◽

Bowel Disease ◽

Response To Therapy ◽

Inflammatory Bowel

Background: Intestinal ultrasound is emerging as a non-invasive tool for monitoring disease activity in inflammatory bowel disease patients due to its low cost, excellent safety profile, and availability. Herein, we comprehensively review the role of intestinal ultrasound in the management of these patients. Summary: Intestinal ultrasound has a good accuracy in the diagnosis of Crohn’s disease, as well as in the assessment of disease activity, extent, and evaluating disease-related complications, namely strictures, fistulae, and abscesses. Even though not fully validated, several scores have been developed to assess disease activity using ultrasound. Importantly, intestinal ultrasound can also be used to assess response to treatment. Changes in ultrasonographic parameters are observed as early as 4 weeks after treatment initiation and persist during short- and long-term follow-up. Additionally, Crohn’s disease patients with no ultrasound improvement seem to be at a higher risk of therapy intensification, need for steroids, hospitalisation, or even surgery. Similarly to Crohn’s disease, intestinal ultrasound has a good performance in the diagnosis, activity, and disease extent assessment in ulcerative colitis patients. In fact, in patients with severe acute colitis, higher bowel wall thickness at admission is associated with the need for salvage therapy and the absence of a significant decrease in this parameter may predict the need for colectomy. Short-term data also evidence the role of intestinal ultrasound in evaluating therapy response, with ultrasound changes observed after 2 weeks of treatment and significant improvement after 12 weeks of follow-up in ulcerative colitis. Key Messages: Intestinal ultrasound is a valuable tool to assess disease activity and complications, and to monitor response to therapy. Even though longer prospective data are warranted, intestinal ultrasound may lead to a change in the paradigm of inflammatory bowel disease management as it can be used in a point-of-care setting, enabling earlier intervention if needed.

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