Impact of oral-health-related quality of life and self-esteem on patients with missing maxillary lateral incisor after orthodontic space closure: a single-blinded, randomized, controlled trial

2020 ◽  
Author(s):  
Matheus Melo Pithon ◽  
Eduardo Otero Amaral Vargas ◽  
Raildo da Silva Coqueiro ◽  
Rogério Lacerda-Santos ◽  
Orlando Motohiro Tanaka ◽  
...  
Keyword(s):  
Oral Health ◽  
Controlled Trial ◽  
Phase 1 ◽  
Self Esteem ◽  
Lateral Incisor ◽  
Phase 2 ◽  
Space Closure ◽  
Related Quality ◽  
Health Related ◽  
Maxillary Lateral Incisor

Summary Background The maxillary lateral incisor is one of the teeth most likely to suffer agenesis, resulting in spacing between the central incisor and the canine. Objective To compare maxillary lateral incisor agenesis with space closure treatment versus non-treatment based on measurements of the self-perceived oral-health-related quality of life (OHRQoL) and self-esteem of the participants. Subjects and methods A total of 44 people, aged 17–49 years, with missing lateral incisors were randomly assigned to two groups (n = 22 in each)—a treated group in which the space was orthodontically closed (TG) and a control group that remained untreated (CG). Randomization was performed by a researcher who was not involved in the clinical part of the study. The outcomes were assessed using the Oral Health Impact Profile and Rosenberg’s Self-Esteem Scale, which were applied before (phase 1) and after (phase 2) the orthodontic treatment in the TG, and at baseline (phase 1) and 12 months after (phase 2) in the CG. All the data were blindly evaluated, supporting the single-blinded design of the study. Results All participants finished the randomized controlled trial, and the demographic characteristics were similar between the groups. In phase 1, the levels of self-esteem and OHRQoL at baseline were similar (P = 0.079, P = 0.693, respectively). In phase 2, the self-esteem scores of the CG decreased and the OHRQoL increased (P = 0.005, P < 0.001, respectively), while self-esteem increased in the TG and the OHRQoL decreased (P < 0.001). The CG had lower scores than the TG for self-esteem, but the opposite was observed for OHRQoL (P < 0.001). Limitations Information bias may have occurred. Since the questionnaires could not have been applied at the same time in both groups, the time difference between the two assessments may have led to random and systematic error. Conclusions The spacing resulting from missing maxillary lateral incisors had a negative impact on the OHRQoL and self-esteem of the participants, while orthodontically closing those spaces had a positive impact on those aspects. Clinical trial registration This study was not registered. Protocol The protocol was not published before trial commencement.

scholarly journals Do aesthetics dental needs interfere in the quality of life of patients?

2017 ◽  
Vol 16 ◽  
pp. 1-10 ◽  
Author(s):  
Karina Ferreira Rizzardi ◽  
Leonardo Caldas Vieira ◽  
Thais Manzano Parisotto ◽  
Cristiane Franco Pinto
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
General Health ◽  
Health Impact ◽  
Self Esteem ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Dental Needs

Aim: The objective was to evaluate oral health-related quality of life (OHRQOL) in patients aging 18 - 60 years, considering oral health, dental aesthetic impact and self-esteem. Methods: The sample comprised 81 patients, regardless gender/ethnicity, seeking for dental aesthetic treatment at University São Francisco, Bragança Paulista-SP. The instruments used to assess the OHRQOL were the questionnaires: 1. Rosenberg Self-Esteem Scale (RSS); 2. Oral Health Impact Profile-14 Brazil (OHIP) and 3. Psychosocial Impact and Aesthetic Dental Questionnaire-Brazil (PIADQ). Data were analyzed by Spearman correlation (α=5%) and descriptive statistics. Results: The older the patient the worse the oral and general health conditions found (p<0.05). Moreover, the age showed significant correlation with OIHP and PIADQ questionnaires scores (p=0.000). The three questionnaires showed moderate positive correlations (p<0.05 r=0.461 – 0.685) among them. In addition, OHIP and QIPED questionnaires correlated with general health and oral health (p<0.05 r=0.230–0.558). Conclusion: It could be concluded that aesthetic dental needs interfere, in fact, in the oral health-related quality of life and in the self-steem of patients seeking for treatment University São Francisco Dental School.

scholarly journals Fitusiran Treatment Impacts on Health-Related Quality of Life in Subjects with Hemophilia A and B with Inhibitors Assessed with the Haemophilia Quality of Life Questionnaire for Adults (Haem-A-QoL)

Blood ◽  
2020 ◽  
Vol 136 (Supplement 1) ◽  
pp. 23-24
Author(s):  
Sylvia Von Mackensen ◽  
Pratima Chowdary ◽  
Sarah Mangles ◽  
Qifeng Yu ◽  
Baisong Mei ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Hemophilia A ◽  
Phase 1 ◽  
Phase 2 ◽  
Publicly Traded ◽  
Advisory Committees ◽  
Related Quality ◽  
Health Related ◽  
Dose Dependent

Background: Fitusiran, an investigational RNA interference treatment for people with hemophilia A or B (PwH), with or without inhibitors, has shown dose-dependent lowering of antithrombin, increase in thrombin generation, and decrease in bleeding frequency in clinical trials. The novel mechanism of action and long pharmacodynamic effect enables once-monthly subcutaneous administration. This sustained hemostatic protection and less burdensome administration may improve patient-reported outcomes (PRO). Objective: To evaluate changes in PRO in terms of patient-relevant improvements in health-related quality of life (HRQoL) in PwH with inhibitors (PwHI) on prophylactic fitusiran treatment. Methods: Fitusiran was evaluated in a phase 1 dose-escalation study (NCT02035605) followed by a phase 2 open-label extension (OLE) study (NCT02554773) with monthly subcutaneous fixed doses of 50 mg or 80 mg. HRQoL was assessed using the Haem-A-QoL and the EuroQol 5 Dimensions (EQ-5D) questionnaires at baseline and at end of study in a cohort of 17 PwHI (Hemophilia A, n=15; Hemophilia B, n=2) from the phase 1 study. Results: Subjects previously treated on-demand or prophylactically had a mean (standard deviation [SD]) age of 34.6 (10.3) years and a mean (SD) number of bleeding episodes in the 6 months before baseline of 16.6 (10.7). Mean (SD) changes from baseline to end of study (day 84 or later) in Haem-A-QoL total (-9.2 [11.2]) and physical health (−12.3 [15.1]) domain scores suggest clinically meaningful improvement (lower scores indicate better HRQoL). Numeric reduction (i.e., improvement) in all other domains appeared to be dose-dependent (greater improvement in the 80 mg group) (Table 1). Changes in EQ-5D utility and EQ-VAS scores were not clinically meaningful. Further analyses in PwH with and without inhibitors from the phase 2 OLE will be presented. Conclusions: Fitusiran prophylaxis may improve HRQoL - particularly the Haem-A-QoL 'Physical health' domain (painful swelling, joint pain, pain with movement, difficulty walking, and time to get ready) as shown in a cohort of 17 PwHI . Additional analyses from ongoing OLE and phase 3 studies are planned to quantify the patient-relevant changes with fitusiran treatment in all hemophilia patients over time. Disclosures Von Mackensen: Sanofi, Bayer, Sobi, Chugai, Kedrion, Spark: Consultancy; Biotest, Sobi, CSL Behring: Honoraria; Novo Nordisk, Sobi: Research Funding. Chowdary:BioMarin: Honoraria; Bayer, CSL Behring, Freeline, Novo Nordisk, Pfizer and Sobi: Research Funding; Chugai, CSL Behring, Novo Nordisk, Pfizer, Roche, Sobi: Speakers Bureau; Bayer, Chugai, CSL Behring, Freeline, Novo Nordisk, Pfizer, Roche, Sanofi, Shire (Baxalta), Sobi, Spark: Membership on an entity's Board of Directors or advisory committees. Mangles:Roche, Takeda, Novo Nordisk: Consultancy, Membership on an entity's Board of Directors or advisory committees; Sobi, Octapharma, Novo Nordisk, Shire and Roche/Chugai: Other: travel funding. Yu:Sanofi: Other: was an employee and stockholder of Sanofi, at the time of study; Albireo Pharmaceuticals, Inc: Current Employment. Mei:Sanofi: Current Employment, Current equity holder in publicly-traded company. Andersson:Sanofi: Current Employment, Current equity holder in publicly-traded company. Dasmahapatra:Sanofi: Current Employment, Current equity holder in publicly-traded company.

Acupuncture for pain, mandibular function and oral health‐related quality of life in patients with masticatory myofascial pain: A randomised controlled trial

2020 ◽  
Vol 47 (10) ◽  
pp. 1193-1201
Author(s):  
Franklin Teixeira Salles‐Neto ◽  
Janice Simpson Paula ◽  
João Gabriel de Azevedo José Romero ◽  
Camila Megale Almeida‐Leite
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Randomised Controlled Trial ◽  
Myofascial Pain ◽  
Controlled Trial ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Randomised Controlled

The effect of a domiciliary denture service on oral health related quality of life: a randomised controlled trial

BDJ ◽  
2007 ◽  
Vol 203 (2) ◽  
pp. E3-E3 ◽  
Author(s):  
N. K. Pearson ◽  
B. J. Gibson ◽  
D. M. Davis ◽  
S. Gelbier ◽  
P. G. Robinson
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Randomised Controlled

scholarly journals Dental Fear and Associated Factors among Children and Adolescents: A School-Based Study in Lithuania

2021 ◽  
Vol 18 (16) ◽  
pp. 8883
Author(s):  
Eglė Slabšinskienė ◽  
Aistė Kavaliauskienė ◽  
Miglė Žemaitienė ◽  
Ingrida Vasiliauskienė ◽  
Apolinaras Zaborskis
Keyword(s):  
Oral Health ◽  
Children And Adolescents ◽  
Social Factors ◽  
Dental Treatment ◽  
Self Esteem ◽  
Dental Fear ◽  
School Based ◽  
Related Quality ◽  
Health Related

Dental fear is a challenging problem in dentistry and many contributing factors have been identified. Although this problem among children and adolescents has been studied in the literature for a long time, few such studies have been conducted in Lithuania. This study aimed to evaluate the prevalence of dental fear and examine its association with gender, age and several psychological and social factors among children and adolescents in Lithuania. The cross-sectional survey included a randomly selected sample (n = 1590) of children aged 11–14 and adolescents aged 15–18. The data were supplemented by interviewing the parents of these subjects (n = 1399). Dental fear was measured with a single five-score question. The data collection also included questions on oral health, socioeconomic status, oral health-related quality of life and self-esteem. Poisson regression analysis was used to assess the association between perception of dental fear and potential predictor variables. It was found that 32.2% (95% CI: 29.9–34.4%) of children and adolescents reported no fear of dental treatment, 12.5% (10.8–14.2%) of their peers were highly afraid of dental treatment, and other subjects assessed their dental fear gradually. Girls reported greater dental fear scores than boys, but the level of dental fear did not depend on the age. We identified the groups of subjects by gender and age, and a higher level of dental fear was significantly associated with untreated caries experience, a delay in the age of the subject’s first visit to the dentist, low self-esteem, low oral health-related quality of life, low overall life satisfaction and low family affluence. The results also suggested that dental fear could originate from previous toothache, dentists’ actions, high sensitivity in the child and poor psychological readiness for treatment. It was concluded that dental fear among Lithuanian children and adolescents is a common problem that is associated with gender and several dental, psychological and social factors. The findings indicate that school-based health policies, paediatric dentists and parents should be encouraged to focus on the psychosocial factors associated with dental fear because most of them can be prevented.

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