scholarly journals Parvovirus B19-induced angiogenesis in fulminant myocarditis

2020 ◽  
Vol 41 (12) ◽  
pp. 1309-1309 ◽  
Author(s):  
Maximilian Ackermann ◽  
Willi L Wagner ◽  
Philipp Rellecke ◽  
Payam Akhyari ◽  
Udo Boeken ◽  
...  
Keyword(s):  
Parvovirus B19 ◽  
Fulminant Myocarditis

Parvovirus B19 myocarditis in children: an observational study

2015 ◽  
Vol 101 (2) ◽  
pp. 177-180 ◽  
Author(s):  
Trisha V Vigneswaran ◽  
Julianne R Brown ◽  
Judith Breuer ◽  
Michael Burch
Keyword(s):  
Parvovirus B19 ◽  
Complete Recovery ◽  
Fulminant Myocarditis ◽  
Circulatory Support ◽  
Free Survival ◽  
St Segment Elevation ◽  
Viral Genomes ◽  
St Segment ◽  
Fractional Shortening ◽  
New Onset

BackgroundThe advent of PCR testing for the presence of viral genomes has led to the identification of parvovirus B19 (PVB19) as a causative agent of myocarditis.MethodsThe clinical presentation, course and outcome of children with PVB19 myocarditis was ascertained through a retrospective review. The PVB19 viral genome was detected by PCR from whole blood or endomyocardial biopsy specimens in patients presenting with new onset heart failure.ResultsSeventeen patients presented at a median age of 1.3 years (range: 0.4–15.4 years) in cardiac failure with a mean fractional shortening of 15±3%. Eleven patients required mechanical ventilation and intravenous inotropes and seven required extra-corporeal mechanical oxygenation. Four of the five deaths occurred in patients who had a short prodromal illness of less than 48 hours. All patients with ST segment elevation died (n=4). All non-fulminant cases survived. Event-free survival occurred in 11/17 (65%) patients. Five (29%) patients died and one patient underwent heart transplantation. Complete recovery of cardiac function occurred within a median of 12 months (range: 1–48) in five patients. There was incomplete recovery in five patients and one patient had persistent dilated cardiomyopathy.ConclusionsPVB19 can cause a devastating myocarditis in children. Children with fulminant myocarditis, ST segment changes or a short prodrome have the worst outcome. Transplantation may be considered, but is rarely required in the acute period if mechanical circulatory support is utilised. If the initial presentation is survived, recovery of the myocardium can occur even in those who had fulminant myocarditis.

Fulminant myocarditis associated with parvovirus B19 infection in a child

2008 ◽  
Vol 42 (1) ◽  
pp. 70-71 ◽  
Author(s):  
Julia Dina ◽  
Astrid Vabret ◽  
Caroline Rambaud ◽  
Alain Checoury ◽  
Stephanie Gouarin ◽  
...  
Keyword(s):  
Parvovirus B19 ◽  
Fulminant Myocarditis ◽  
Parvovirus B19 Infection

scholarly journals Fulminant myocarditis parvovirus B19 related in a young woman

2021 ◽  
Author(s):  
Rita Pesce ◽  
PierPaolo Taffarello ◽  
Stefania Rizzo ◽  
Cristina Basso ◽  
Luisa Cacciavillani ◽  
...  
Keyword(s):  
Young Woman ◽  
Continuous Flow ◽  
Parvovirus B19 ◽  
Surgical Strategy ◽  
Fulminant Myocarditis ◽  
Anatomical Features ◽  
Ultrasound Evaluation ◽  
Lymphocytic Myocarditis ◽  
Percutaneous Device

AbstractWe present the case of a 18-year-old female with fulminant lymphocytic myocarditis caused by Parvovirus B19 (PVB19), successfully treated using temporary LVAD. In the literature there is no consensus on the surgical strategy. While some surgeons prefer to use a single device supporting only the LV, others prefer to start immediately with a biventricular supporting. At pre-procedural ultrasound evaluation, her anatomical features were not suitable for a percutaneous device such as the Impella. Thus, a temporary paracorporeal continuous flow LVAD was inserted. The heart recovery allowed LVAD removal 9 days after the implant.

Parvovirus-B19-associated fulminant myocarditis successfully treated with immunosuppressive and antiviral therapy

2010 ◽  
Vol 15 (4) ◽  
pp. 681-685 ◽  
Author(s):  
Robert Dennert ◽  
Sebastiaan Velthuis ◽  
Dirk Westermann ◽  
Dirk Donker ◽  
Simon Schalla ◽  
...  
Keyword(s):  
Antiviral Therapy ◽  
Parvovirus B19 ◽  
Fulminant Myocarditis

scholarly journals Coinfection of Parvovirus B19 with Influenza A/H1N1 Causes Fulminant Myocarditis and Pneumonia. An Autopsy Case Report

Pathogens ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 958
Author(s):  
Domitille Callon ◽  
Fatma Berri ◽  
Anne-Laure Lebreil ◽  
Paul Fornès ◽  
Laurent Andreoletti
Keyword(s):  
Viral Load ◽  
Influenza A ◽  
Acute Myocarditis ◽  
Parvovirus B19 ◽  
Fatal Outcome ◽  
High Viral Load ◽  
Viral Reactivation ◽  
Fulminant Myocarditis ◽  
Viral Interactions ◽  
Influenza A H1n1

Parvovirus-B19 (PVB19) is a frequent causative agent of myocarditis. For unclear reasons, viral reactivation can cause acute myocarditis, a leading cause of sudden death in the young. Influenza A/H1N1(2009) virus (IAV/H1N1) is known for causing flu/pneumonia, but the heart is rarely involved. Co-infections of cardiotropic viruses are rarely reported and the mechanisms of viral interactions remain unknown. A 5-year old girl had a flu-like syndrome, when she suddenly presented with a respiratory distress and cardiac arrest. At autopsy, the lungs were found haemorrhagic. Lungs’ histology showed severe bronchiolitis, diffuse haemorrhagic necrosis, and mononuclear inflammation. In the heart, a moderate inflammation was found with no necrosis. IAV/H1N1 was detected in nasal and tracheal swabs, lungs, and the heart. The viral load was high in the lungs, but low in the heart. PVB19 was detected in the heart with a high viral load. Viral co-infection increases the risk of severe outcome but the mechanisms of interaction between viruses are poorly understood. In our case, viral loads suggested a reactivated PVB19-induced acute myocarditis during an IAV/H1N1 pneumonia. Viral interactions may involve an IAV/H1N1-induced cytokine storm, with a fulminant fatal outcome. Clinically, our case shows the importance of investigating inflammatory pathways as therapeutic targets.

scholarly journals Fulminant myocarditis as an early presentation of SARS-CoV-2

2020 ◽  
Vol 13 (9) ◽  
pp. e237553 ◽  
Author(s):  
Tamara Naneishvili ◽  
Arsalan Khalil ◽  
Ryan O'Leary ◽  
Neeraj Prasad
Keyword(s):  
Viral Infections ◽  
Case Reports ◽  
Parvovirus B19 ◽  
Ventilatory Support ◽  
Coxsackie Virus ◽  
Fulminant Myocarditis ◽  
Caucasian Woman ◽  
Myocardial Inflammation ◽  
Second Phase ◽  
Early Presentation

Myocarditis is well known to be caused by viral infections such as Coxsackie virus group B, human herpes virus 6 and parvovirus B19. However, during the current emerging outbreak of SARS-CoV-2, there have been few case reports describing myocarditis as a possible presentation. In our case report we describe, early cardiac manifestations of SARS-CoV-2 in a UK District General Hospital. A 44-year-old Caucasian woman without any comorbidities presented with SARS-CoV-2 related fulminant myocarditis without initial respiratory symptoms. Patient underwent treatment with milrinone and methylprednisolone that showed reduction in myocardial inflammation and significantly improved myocardial contractility. This was then followed by a second phase of SARS-CoV-2 associated pneumonia and renal failure requiring ventilatory support and haemofiltration. Although, not described in the literature, we have found conjunctive use of milrinone and methylprednisolone effective in patient with SARS-CoV-2 fulminant myocarditis.

scholarly journals PARVOVIRUS B19 INDUCED MYOCARDITIS, SIMULATING ACUTE MYOCARDIAL INFARCTION

2021 ◽  
Vol 9 (10) ◽  
pp. 1351-1355
Author(s):  
Harshad Rajge ◽  
◽  
Keshav Kale ◽  
Niti Bhatwal ◽  
G.R. Kane ◽  
...  
Keyword(s):  
Parvovirus B19 ◽  
Supportive Therapy ◽  
Chemotherapeutic Agents ◽  
Cardiac Biomarkers ◽  
Coxsackie Virus ◽  
Fulminant Myocarditis ◽  
St Segment Elevation ◽  
St Segment ◽  
Diagnostic Confusion ◽  
Electrocardiographic Changes

Myocarditis is an inflammation of the myocardium associated with mechanical or electrical dysfunctions that usually lead to inappropriate ventricular dilatation or hypertrophy. A number of inciting factors are known to cause myocarditis- genetic defects, viruses, bacteria, parasites, granulomatous inflammations, collagen vascular disorders, chemotherapeutic agents- to name a few. Among the viruses, Adenovirus, Coxsackie virus, Human Herpes virus six and Parvovirus B19 are the encountered pathogens. We hereby present a case of a 14 years old boy who presented with typical cardiac chest pain associated with electrocardiographic changes of ST segment elevation MI in theinferior leads. Cardiac biomarkers were elevated, adding to the diagnostic confusion of MI. On subjecting the patient to a coronary angiography, his arteries were found to be patent, directing us towards the diagnosis of myocarditis. After getting a cardiac MRI and serum tests, the diagnosis of fulminant myocarditis induced by Parvovirus B19 was made. Fortunately, the patient survived on inotropes and other supportive therapy which helped him overcome the cardiac failure.

Parvovirus B19 transmitted by bone marrow

2000 ◽  
Vol 111 (2) ◽  
pp. 659-661 ◽  
Author(s):  
Erik D. Heegaard ◽  
Bodil Laub Petersen
Keyword(s):  
Bone Marrow ◽  
Parvovirus B19
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