scholarly journals Beneficial early effects of statin treatment on coronary microvascular dysfunction and left ventricular remodeling in patients with acute anterior myocardial infarctions

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. P2225-P2225
Author(s):  
K. Ishida ◽  
M. Koike ◽  
H. Uzui ◽  
N. Amaya ◽  
K. Arakawa ◽  
...  
Keyword(s):  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Microvascular Dysfunction ◽  
Statin Treatment ◽  
Left Ventricular ◽  
Myocardial Infarctions ◽  
Coronary Microvascular Dysfunction ◽  
Early Effects

scholarly journals Traditional Chinese Medicine Tongxinluo Improves Cardiac Function of Rats with Dilated Cardiomyopathy

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Fang-Fang Shen ◽  
Ting-Hui Jiang ◽  
Jin-Qi Jiang ◽  
Ying Lou ◽  
Xu-Min Hou
Keyword(s):  
Cardiac Function ◽  
Dilated Cardiomyopathy ◽  
Rat Model ◽  
Normal Saline ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Microvascular Dysfunction ◽  
Left Ventricular ◽  
Coronary Microvascular Dysfunction ◽  
High Dose

The study aimed at testing the hypothesis that tongxinluo capsule might exert its cardioprotective effect by preventing ventricular remodeling and improving coronary microvascular function in a rat model of doxorubicin-induced dilated cardiomyopathy (DCM). Rats that survived DCM induction were randomly divided into three groups to be given 1.5 g·kg−1·day−1(TXL-H,n=9) or 0.15 g·kg−1·day−1(TXL-L,n=10) of tongxinluo, or normal saline at the same volume (DCM-C,n=10) intragastrically. Age matched normal rats treated with normal saline were used as normal controls (NOR-C,n=9). After four weeks of treatment, the DCM-C, TXL-H, and TXL-L groups exhibited significant cardiac dysfunction, left ventricular remodeling, and coronary microvascular dysfunction, compared with the NOR-C rats. However, myocardial functional parameters were significantly improved and microvascular density (MVD) increased in the TXL-H group compared with the DCM-C group (allP<0.01). Left ventricular remodeling was prevented. There were close linear relationships between CVF and LVEF (r=-0.683,P<0.05), MVD and LVEF (r=0.895,P<0.05), and MVD and CVF (r=-0.798,P<0.05). It was indicated that high-dose tongxinluo effectively improved cardiac function in rat model of DCM.

scholarly journals Coronary Microcirculation in Aortic Stenosis: Pathophysiology, Invasive Assessment, and Future Directions

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Jo M. Zelis ◽  
Pim A. L. Tonino ◽  
Nico H. J. Pijls ◽  
Bernard De Bruyne ◽  
Richard L. Kirkeeide ◽  
...  
Keyword(s):  
Aortic Stenosis ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Myocardial Dysfunction ◽  
Clinical Care ◽  
Microvascular Dysfunction ◽  
Left Ventricular ◽  
Link Type ◽  
Microcirculatory Function ◽  
Epicardial Stenosis

With the increasing prevalence of aortic stenosis (AS) due to a growing elderly population, a proper understanding of its physiology is paramount to guide therapy and define severity. A better understanding of the microvasculature in AS could improve clinical care by predicting left ventricular remodeling or anticipate the interplay between epicardial stenosis and myocardial dysfunction. In this review, we combine five decades of literature regarding microvascular, coronary, and aortic valve physiology with emerging insights from newly developed invasive tools for quantifying microcirculatory function. Furthermore, we describe the coupling between microcirculation and epicardial stenosis, which is currently under investigation in several randomized trials enrolling subjects with concomitant AS and coronary disease. To clarify the physiology explained previously, we present two instructive cases with invasive pressure measurements quantifying coexisting valve and coronary stenoses. Finally, we pose open clinical and research questions whose answers would further expand our knowledge of microvascular dysfunction in AS. These trials were registered with NCT03042104, NCT03094143, and NCT02436655.

Oral Nitrate Administration Ameliorates Cardiogenic Shock due to Eclipsed Mitral Regurgitation

Cardiology ◽  
2016 ◽  
Vol 134 (3) ◽  
pp. 327-330 ◽  
Author(s):  
Mai Kimura ◽  
Takashi Kohno ◽  
Mitsushige Murata ◽  
Tadaki Nakahara ◽  
Kai Sugihara ◽  
...  
Keyword(s):  
Mitral Regurgitation ◽  
Cardiogenic Shock ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Coronary Spasm ◽  
Microvascular Dysfunction ◽  
Left Ventricular ◽  
Mitral Leaflet ◽  
Life Threatening ◽  
Lateral Posterior

Eclipsed mitral regurgitation (MR) has been reported as transient massive functional MR caused by a sudden coaptation defect in the absence of left ventricular remodeling or epicardial coronary artery stenosis. Coronary spasm or microvascular dysfunction has been suggested to be associated with the pathogenesis. Here, we present a 68-year-old woman with eclipsed MR with cardiogenic shock ameliorated by nitrate. She was admitted for transient shock with massive functional MR. Transient MR was associated with a complete absence of mitral leaflet coaptation owing to tethering of the lateral posterior mitral leaflet. The leaflet tethering was triggered by transient myocardial ischemia around the anterolateral papillary muscle, which could have been caused by coronary spasm and/or microvascular dysfunction. During admission, she experienced similar repeated episodes, which were ameliorated by oral nitrate administration. This is the first described case of eclipsed MR with shock ameliorated by nitrate. Although eclipsed MR, a cause of life-threatening shock, is uncommon, we need to keep in mind that nitrate administration could be a treatment option even in patients with cardiogenic shock.

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