scholarly journals P6316Prediction of 10-year mortality in adults with congenital heart disease using disease severity and functional indices

2017 ◽  
Vol 38 (suppl_1) ◽  
Author(s):  
F. Ombelet ◽  
E. Goossens ◽  
S. Apers ◽  
W. Budts ◽  
M. Gewillig ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Disease Severity ◽  
Congenital Heart ◽  
Functional Indices

scholarly journals Predicting 15-Year Mortality in Adults With Congenital Heart Disease Using Disease Severity and Functional Indices

2019 ◽  
Vol 35 (7) ◽  
pp. 907-913 ◽  
Author(s):  
Fouke Ombelet ◽  
Eva Goossens ◽  
Silke Apers ◽  
Werner Budts ◽  
Marc Gewillig ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Disease Severity ◽  
Congenital Heart ◽  
Functional Indices

The impact of actual and perceived disease severity on pre-operative psychological well-being and illness behaviour in adult congenital heart disease patients

2013 ◽  
Vol 24 (2) ◽  
pp. 275-282 ◽  
Author(s):  
Edward Callus ◽  
Elisabeth M. W. J. Utens ◽  
Emilia Quadri ◽  
Cristian Ricci ◽  
Mario Carminati ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Disease Severity ◽  
Cardiac Disease ◽  
Congenital Heart ◽  
Well Being ◽  
Illness Behavior ◽  
Psychological State ◽  
Illness Behaviour ◽  
Psychological Well Being

AbstractObjectives: The purpose of this study was to investigate whether the objective medical parameters related to congenital heart disease and patients’ ratings of cardiac disease severity were related to psychological well-being and illness behaviour during the pre-operative period.Methods: A total of 143 patients (63 male patients; 16–73 years old) with congenital heart disease evaluated the severity of their cardiac condition using a numerical rating scale ranging from 0, indicating the least severe condition, to 100, indicating the most severe condition. Psychological well-being was assessed using the Psychological General Well-Being Index (total score ≤60 indicating severe distress) and illness behaviour using the Illness Behavior Questionnaire.Results: Pre-operative psychological well-being was not related to the objective medical parameters reflecting cardiac disease severity. In contrast, total psychological well-being scores correlated significantly with patients’ subjective ratings of disease severity (p < 0.001). When compared with the reference values from the Italian population, the mean scores of the patients on psychological well-being were similar. As regards the Illness Behavior Questionnaire, the scores on denial were higher and those on hypochondria were lower compared with other hospitalised patients.Conclusions: This study shows that the perception of cardiac disease severity, and not the medical parameters in congenital heart disease, is related to the patients’ pre-operative psychological state. Thus, more importance needs to be given to assessing the patients’ pre-operative perception and psychological state independently of cardiac severity. Targeted interventions with regard to the cardiac condition are recommended.

scholarly journals Quality of life of adult congenital heart disease patients: a systematic review of the literature

2013 ◽  
Vol 23 (4) ◽  
pp. 473-485 ◽  
Author(s):  
Theodora Fteropoulli ◽  
Jan Stygall ◽  
Shay Cullen ◽  
John Deanfield ◽  
Stanton P. Newman
Keyword(s):  
Quality Of Life ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Disease Severity ◽  
Congenital Heart ◽  
Adult Congenital Heart Disease ◽  
Adult Population ◽  
Targeted Interventions ◽  
Adult Congenital

AbstractAimsThis review explores the quality of life of adult congenital heart disease patients and the relationship between disease severity and quality of life.MethodsWe searched seven electronic databases and the bibliography of articles. The 31 selected studies fulfilled the following criteria: adult population; quantitative; assessment of quality of life and/or impact of disease severity on quality of life using validated measures; English language. Data extraction forms were used to summarise the results.ResultsThere are evident methodological limitations within the reviewed studies such as heterogeneous populations, designs, and quality of life conceptualisations and measurements. Despite these problems, findings suggest that the quality of life of adult congenital heart disease patients is compromised in the physical domain compared with their healthy counterparts, whereas no differences were found in relation to the psychosocial and environmental/occupational domain. Some severity variables appear to be significant correlates of quality of life and could be considered in a future standardised classification of disease severity.ConclusionThe methodological limitations of past research in relation to the definition and measurement of quality of life, the study designs, and disease severity classifications need to be addressed in future studies in order to provide robust evidence and valid conclusions in this area of study. This will enable the development of targeted interventions for the improvement of quality of life in the adult population of congenital heart disease patients.

Utility of 3D Printed Cardiac Models for Medical Student Education in Congenital Heart Disease: Across a Spectrum of Disease Severity

2019 ◽  
Vol 40 (6) ◽  
pp. 1258-1265 ◽  
Author(s):  
Jennifer Smerling ◽  
Charles C. Marboe ◽  
Jay H. Lefkowitch ◽  
Martina Pavlicova ◽  
Emile Bacha ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Medical Student ◽  
Disease Severity ◽  
Congenital Heart ◽  
Medical Student Education ◽  
Student Education ◽  
3D Printed ◽  
Cardiac Models

scholarly journals Intra-atrial re-entrant tachycardia in patients with congenital heart disease: factors associated with disease severity

EP Europace ◽  
2017 ◽  
Vol 20 (8) ◽  
pp. 1343-1351 ◽  
Author(s):  
Ivo Roca-Luque ◽  
Nuria Rivas Gándara ◽  
Laura Dos Subirà ◽  
Jaume Francisco Pascual ◽  
Jordi Pérez-Rodon ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Disease Severity ◽  
Congenital Heart ◽  
Factors Associated

Abstract 14979: Endostatin as a Predictor of Severity and Survival in Pediatric Congenital Heart Disease Associated Pulmonary Hypertension

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Caroline Daly ◽  
Megan Griffiths ◽  
Jun Yang ◽  
Melanie Nies ◽  
Rachel L Damico ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Disease Severity ◽  
Congenital Heart ◽  
Right Atrial ◽  
Pulmonary Vascular Disease ◽  
Multiple Time ◽  
Angiogenic Inhibitor ◽  
Kaplan Meier ◽  
Increased Risk

Introduction: Pediatric pulmonary arterial hypertension (PAH) is a multifactorial pulmonary vascular disease with high mortality. Endostatin (ES), an angiogenic inhibitor, is associated with disease severity and mortality in adults with PAH and poor lung growth in children. Hypothesis: Increased ES is associated with worse disease severity and outcomes in pediatric PAH. Methods: Serum ES levels were measured in two cohorts of pediatric PAH (IPAH, FPAH and APAH) patients; the cross-sectional CCHMC PAH Biobank (PAHB, N=175) and a longitudinal cohort from Children’s Hospital of Colorado (CHC, N=61). Outcomes included medical therapy, functional and hemodynamic measures, and survival (death, transplant, palliative shunt). Adjusted logistic and linear regressions and Kaplan-Meier analysis were used to assess the relationship between ES and clinical outcomes. Results: In both cohorts, ES was significantly higher in PAH associated with congenital heart disease (APAH-CHD, PAHB n=70, p=0.002; CHC n=29, p=0.007) and was highest in those with a ventricular shunt (n=24, p=0.001). In APAH-CHD, ES was associated with a decreased 6MWD (-108m, -187- -30, p=0.01) and increased mean right atrial pressure (mRAP 1.8mmHg, 0.3-3.3, p=0.02). Longitudinally, in the APAH-CHD subgroup when adjusted for age, sex, and multiple time points, higher ES was associated with increased PVRi and mPAP (PVRi 2.5WU*m 2 , 0.7-4.3, p=0.007; mPAP 10mmHg, 4.5-15, p<0.001). Kaplan-Meier analysis (Figure 1) demonstrated that ES was associated with worse outcomes in both cohorts, with an adjusted Cox proportional hazard ratio of 4.3 (1.13-16, p=0.03) in the PAHB. Conclusions: ES was associated with worse functional measures, pulmonary vascular hemodynamics, and survival in pediatric APAH-CHD. These observations suggest that serum ES could act as a pulmonary vascular specific biomarker to identify those who are at increased risk of developing PAH and predict poor outcomes in APAH-CHD.

The impact of illness perceptions and disease severity on quality of life in congenital heart disease

2015 ◽  
Vol 26 (1) ◽  
pp. 100-109 ◽  
Author(s):  
Claire E. O’Donovan ◽  
Liz Painter ◽  
Boris Lowe ◽  
Hayley Robinson ◽  
Elizabeth Broadbent
Keyword(s):  
Quality Of Life ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Disease Severity ◽  
Congenital Heart ◽  
Illness Perceptions ◽  
Psychological Outcomes ◽  
Relative Impact ◽  
Regression Analyses

AbstractBackgroundDespite an increasing prevalence of adults living with a CHD, little is known about the psychosocial impact of CHD. We sought to investigate the relative impact of disease severity and patients’ perceptions about their condition on depression, anxiety, and quality of life over a period of a year.MethodsA total of 110 patients aged over 16 years completed an initial questionnaire containing measures for anxiety, depression, quality of life, and illness perceptions when they attended the Adult Congenital Heart Disease Clinic. Cardiologists rated the patients’ disease severity and illness course. A year later, patients were invited to complete the same measures. Regression analyses were performed to determine the relative impact of illness perceptions and disease severity on psychological outcomes a year later.ResultsAt baseline, 23% of the study population had depressive symptoms and 30% had elevated trait anxiety. After controlling for associations with disease-related variables, illness perceptions explained 28% of the variance in depression, 40% anxiety, and 27% overall quality of life at baseline. Baseline illness perceptions bivariately predicted quality of life, cardiac anxiety, and depression 1 year later, and regression analyses controlling for other factors showed that they were significant predictors of outcomes 1 year later.ConclusionSymptoms of depression and anxiety are common among adults with CHD. Patients’ illness perceptions are related to psychological outcomes, especially cross-sectionally. Future research could investigate whether an intervention to discuss patients’ perceptions about their CHD can improve mental health and quality of life.

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