scholarly journals P3448Validity of accelerometer cut-points and level of free-living physical activity in the oldest old patients with coronary artery disease

2017 ◽  
Vol 38 (suppl_1) ◽  
Author(s):  
M. Back ◽  
S. Strauch ◽  
M. Hagstromer
2015 ◽  
Vol 65 (10) ◽  
pp. A1618
Author(s):  
Nobutaka Ikeda ◽  
Hisao Hara ◽  
Yukio Hiroi ◽  
Masato Nakamura ◽  
Kaoru Sugi

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0137759 ◽  
Author(s):  
Stephanie A. Prince ◽  
Jennifer L. Reed ◽  
Amy E. Mark ◽  
Christopher M. Blanchard ◽  
Sherry L. Grace ◽  
...  

Author(s):  
Martin Bahls ◽  
Michael F. Leitzmann ◽  
André Karch ◽  
Alexander Teumer ◽  
Marcus Dörr ◽  
...  

Abstract Aims Observational evidence suggests that physical activity (PA) is inversely and sedentarism positively related with cardiovascular disease risk. We performed a two-sample Mendelian randomization (MR) analysis to examine whether genetically predicted PA and sedentary behavior are related to coronary artery disease, myocardial infarction, and ischemic stroke. Methods and results We used single nucleotide polymorphisms (SNPs) associated with self-reported moderate to vigorous PA (n = 17), accelerometer based PA (n = 7) and accelerometer fraction of accelerations > 425 milli-gravities (n = 7) as well as sedentary behavior (n = 6) in the UK Biobank as instrumental variables in a two sample MR approach to assess whether these exposures are related to coronary artery disease and myocardial infarction in the CARDIoGRAMplusC4D genome-wide association study (GWAS) or ischemic stroke in the MEGASTROKE GWAS. The study population included 42,096 cases of coronary artery disease (99,121 controls), 27,509 cases of myocardial infarction (99,121 controls), and 34,217 cases of ischemic stroke (404,630 controls). We found no associations between genetically predicted self-reported moderate to vigorous PA, accelerometer-based PA or accelerometer fraction of accelerations > 425 milli-gravities as well as sedentary behavior with coronary artery disease, myocardial infarction, and ischemic stroke. Conclusions These results do not support a causal relationship between PA and sedentary behavior with risk of coronary artery disease, myocardial infarction, and ischemic stroke. Hence, previous observational studies may have been biased. Graphic abstract


2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Wan-Ting Huang ◽  
Chieh-Yu Liu ◽  
Huei-Fong Hung ◽  
Shu-Pen Hsu ◽  
Ai-Fu Chiou

2014 ◽  
Vol 36 (11) ◽  
pp. 1518-1530 ◽  
Author(s):  
Janey C. Peterson ◽  
Mary E. Charlson ◽  
Martin T. Wells ◽  
Margaret Altemus

2015 ◽  
Author(s):  
Elizabeth G Nabel

Numerous observational studies have demonstrated an inverse relationship between physical activity and risk of many chronic illnesses. The protective effect of exercise is strongest against coronary artery disease, hypertension, stroke, type 2 diabetes mellitus, obesity, anxiety, depression, osteoporosis, and cancers of the colon and breast. Despite these proven benefits, only 25% of adults in the United States exercise at recommended levels. Globally, physical inactivity is the fourth leading risk factor for death, followed by overweight and obesity. This module describes exercise physiology, including cardiovascular response to dynamic exercise, pulmonary response, musculoskeletal response, metabolic effects, effects on blood lipid levels, hematologic effects, effects on vascular inflammation, effects on body fluids, and psychological effects. Exercise and the elderly and the relationship between exercise and longevity are reviewed. Prescribing exercise and complications of exercise are also discussed. Tables describe the categories of patients screened for possible coronary artery disease, exercise time required to consume 2,000 kcal, and exercise advice for patients. Figures include a graph showing the number of adults who met the federal physical activity guidelines criteria, the top 10 global risk factors for death in 2004, the process of providing energy for the muscle, and trends in physician prescriptions for exercise. This module contains 4 highly rendered figures, 3 tables, 35 references, and 5 MCQs.


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