Purpose: i) To determine the relationship between the cardiac biomarkers ST2 and NT-proBNP with ejection fraction (EF)
in heart failure (HF) patients. ii) Assess whether a superiority existed between the aforementioned cardiac markers in
diagnosing the HF with reduced EF. iii) Determine the efficacy of both biomarkers in predicting a 30-day cardiovascular
event and rehospitalization in patients with HF with reduced EF iv) To assess the influence of age, gender, BMI, anaemia
and renal failure on the ST2 and NT-proBNP levels. Design and Methods: A prospective double-blind study was conducted
to obtain data from a sample of 64 cardiology patients. A blood sample was collected to test for ST2 and NT-proBNP. An
echocardiogram (to obtain EF value), electrocardiogram and questionnaire were also obtained. Results: Of the 64 patients
enrolled, 59.4% of the population had an EF less than 40%. At the end of the 30- day period, 7 patients were warded, 37
were not warded, one died and 17 were non respondent. Both biomarkers were efficacious at diagnosing HF with a reduced
EF. However, neither of them were efficacious in predicting 30-day rehospitalization. The mean NT-proBNP values being:
not rehospitalized (2114.7486) and 30 day rehospitalization (1008.42860) and the mean ST2 values being: not
rehospitalized (336.1975), and 30-day rehospitalization. (281.9657). Conclusion: Neither ST2 or NT-proBNP was
efficacious in predicting the short- term prognosis in HF with reduced EF. Both however were successful at confirming the
diagnosis of HF in HF patients with reduced EF.
P3985Analysis of the novel cardiac biomarkers ST2, GDF-15, suPAR, H-FABP and Fetuin A in heart failure with reduced ejection fraction