3288CT-derived fractional flow reserve in patients with stable angina pectoris: A real world follow-up study

2018 ◽  
Vol 39 (suppl_1) ◽  
Author(s):  
T V Kvist ◽  
B L Noergaard ◽  
H E Boetker ◽  
O N Mathiassen ◽  
E L Grove ◽  
...  
Keyword(s):  
Angina Pectoris ◽  
Fractional Flow Reserve ◽  
Real World ◽  
Stable Angina ◽  
Stable Angina Pectoris ◽  
Fractional Flow ◽  
Follow Up Study ◽  
Flow Reserve

scholarly journals Coronary Intervention for Stable Angina Pectoris: The use of Fractional Flow Reserve as a decision making tool for Coronary Angioplasty

2013 ◽  
pp. 43-7
Author(s):  
Januar Wibawa Martha
Keyword(s):  
Decision Making ◽  
Angina Pectoris ◽  
Fractional Flow Reserve ◽  
Stable Angina ◽  
Coronary Angioplasty ◽  
Stable Angina Pectoris ◽  
Fractional Flow ◽  
Health Economic Analysis ◽  
Flow Reserve ◽  
Decision Making Tool

Coronary angioplasty is a definitive, percutaneous intervention to improve myocardial oxygen supply. The benefit of coronary angioplasty for stable angina pectoris is still a controversy. The COURAGE trial had shown that angioplasty for stable angina pectoris gave no additional benefit compared with optimal medical therapy, while the recently done FAME II trial showed the opposite. FAME II trial proved that angioplasty could reduce MACEs in stable angina pectoris patients. The conflicting results from COURAGE and FAME II trials is due to the difference in decision making methodology used for angioplasty. COURAGE used plain angiogram while FAME II utilized Fractional Flow Reserve (FFR) as a tool to decide whether a lesion should undergo angioplasty. The result of FAME II demonstrate FFR is far more reliable to determine coronary lesion which cause ischemia, hence a better decision making tool for angioplasty. The specificity of FFR is proven high, while angiography has an excessive false positives. The use of FFR before angioplasty is still low although there is a considerable evidence that FFR is a better decion making tool for angioplasty compared to angiography. Health economic analysis displayed the use of FFR for stable angina pectoris is cost effective in the long term.

Value of C-reactive protein in patients with stable angina pectoris, coronary narrowing (30% to 70%), and normal fractional flow reserve

2003 ◽  
Vol 92 (6) ◽  
pp. 702-705 ◽  
Author(s):  
Martijn Meuwissen ◽  
Robbert J de Winter ◽  
Steven A.J Chamuleau ◽  
Mechteld Heijne ◽  
Karel T Koch ◽  
...  
Keyword(s):  
Angina Pectoris ◽  
Fractional Flow Reserve ◽  
Stable Angina ◽  
C Reactive Protein ◽  
Stable Angina Pectoris ◽  
Fractional Flow ◽  
Reactive Protein ◽  
Flow Reserve

Abstract 15758: Relationship Between Physiological Coronary Artery Stenosis Severity Assessed by Fractional Flow Reserve and Optical Coherence Tomography Findings in Stable Angina Pectoris

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Tetsumin Lee ◽  
Tadashi Murai ◽  
Yoshihisa Kanaji ◽  
Eisuke Usui ◽  
Makoto Araki ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Coronary Artery ◽  
Angina Pectoris ◽  
Stable Angina ◽  
Coronary Stenosis ◽  
Coronary Artery Stenosis ◽  
Stable Angina Pectoris ◽  
Fractional Flow ◽  
Flow Reserve ◽  
Stenosis Severity

Backgrounds: The aim of the present study is to investigate the relationship between physiological coronary artery stenosis severity and lesion instability by Optical Coherence Tomography (OCT) in patients with stable angina pectoris (SAP). Methods and Results: We investigated 198 culprit lesions of 180 SAP patients who underwent OCT imaging and fractional flow reserve (FFR) measurement before PCI procedure. Physiological coronary stenosis severity was assessed by FFR analysis, and lesions were divided into two groups on the basis of FFR values; severe stenosis group (group S): FFR <0.75 (n=78, 39%), moderate stenosis group (group M): FFR ≥0.75 (n=120, 61%) according to the previous study. Thin-capped fibroatheroma (TCFA) was defined as lipid-rich plaque (lipid arc ≥90°) with fibrous cap thickness <70μm. The median FFR values in total lesions, group S, and group M were 0.77 (interquartile range [IQR]: 0.69—0.83), 0.65 (0.57—0.72), and 0.81 (0.78—0.87), respectively. There were no significant differences in patient characteristics expect for the frequency of previous myocardial infarction (S: 15%, M: 38%, P <0.01) and previous PCI (S: 29%, M: 60%, P <0.01). In angiographic analysis, there were significant differences in the frequency of culprit lesion location in LAD (S: 72%, M: 49%, P <0.01), minimum lumen diameter (S: 1.07±0.36 mm, M: 1.35±0.32 mm, P <0.01), % diameter stenosis (S: 58.9 % [53.1—70.8], M: 52.8 % [47.7—57.5], P <0.01), and lesion length (S: 13.7 mm [10.6—17.5], M: 11.5 mm [9.2—14.5], P = 0.02) between the two groups. In OCT analysis, there were significant differences in the lipid arc (S: 200° [160—232], M: 168° [143—211], P <0.01), CT (S: 110 μm [63—157], M: 140 μm [93—197], P <0.01), and frequency of TCFA (S: 27%, M: 9%, P <0.01) between the two groups. Subgroup analysis of LAD lesions showed similar results between the two groups. Conclusions: Lesions of physiologically severe coronary stenosis in SAP were associated with lesion instability assessed by OCT. These findings may challenge the concept that lesions responsible for acute coronary syndromes are mild in most cases provided that plaque rupture of TCFA evenly results in coronary events in the wide range of stenosis severity in patients with SAP.

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