P1890Is chronic obstructive pulmonary disease associated with increased risk of atrial arrhythmias after ST-segment elevation myocardial infarction?

Objective: To study the levels of heat shock protein 70 (HSP70) and annexin V-dependent apoptosis of cells in myocardial infarction (MI) with a different course of the disease and in the setting of chronic obstructive pulmonary disease (COPD).Materials and Methods: Sixty-five patients with MI were examined; 37 of them developed MI in the setting of COPD, and 28 patient had MI without COPD. The subjects were divided into subgroups depending on the presence of ST segment elevation. The control group included 30 somatically healthy individuals.Results: In all examined patients with MI and in patients with MI with COPD, the number of annexin V-associated apoptotic cells and the level of HSP70 was statistically significantly higher than in healthy individuals. The value of the studied biomarkers was statistically significantly higher than in patients without COPD. In patients with MI with ST segment elevation, the values of the studied biomarkers were statistically significantly higher in patients without ST segment elevation in all the examined patients.Conclusions: Higher values of the studied biomarkers in the group of comorbid patients compared with those with MI without COPD may be associated with intensified apoptosis in the setting of chronic systemic inflammation, which worsens the clinical course of both diseases. The greater significance of the levels of HSP70 and annexin V-dependent cell apoptosis in patients with MI with ST segment elevation compared with patients without ST segment elevation is due to the volume of myocardial lesion.

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CORONARY CIRCULATION CHANGES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION: ANGIOGRAPHY DATA

Bulletin physiology and pathology of respiration ◽

10.12737/article_5b1896e7cb8e08.22551994 ◽

2018 ◽

Vol 1 (68) ◽

pp. 34-39

Author(s):

Евгения Димова ◽

Evgeniya Dimova

Keyword(s):

Myocardial Infarction ◽

Chronic Obstructive Pulmonary Disease ◽

Pulmonary Disease ◽

Coronary Arteries ◽

St Elevation Myocardial Infarction ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

St Segment Elevation ◽

St Segment ◽

St Elevation

The aim of the study was to investigate coronary arteries damage during ST-elevation myocardial infarction (STEMI) manifestation in patients with chronic obstructive pulmonary disease (COPD). The protocols of coronary angiography of 90 patients who suffered STEMI were analyzed. The patients were divided into two groups depending on the presence of COPD. The first group (50 people) was formed from the patients who had ST elevation myocardial infarction (STEMI) and COPD. The second group (40 people) had STEMI and no COPD. It was found that in case of COPD and STEMI comorbidity the number of coronary stenosis is bigger than in case of mono AMI patients. In the group of patients with COPD and STEMI the angiographic picture of atherosclerosis damage of coronary arteries demonstrates the prevalence of medium and distal stenosis of major branches and coronary arteries of the second order unlike the group with isolated STEMI. The number of extended stenosis in the group with the comorbid pathology is also higher. The patients with STEMI have the same number of hemodynamically important stenosis as the other group. The correlation between the change of the vessel channel and smoking anamnesis, the level of the systematic inflammation marker (CRP) and the level of lipids in patients with COPD and STEMI was studied. The severity of coronary atherosclerosis directly correlates with CRP level, smoking anamnesis, level of cholesterol, LDLP. The number of distal stenosis, including those that are hemodynamically important, has reverse correlation with the level of HDLP.

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P813Chronic obstructive pulmonary disease is associated with higher mortality from ST-segment elevation myocardial infarction but not from non ST-segment elevation myocardial infarction

European Heart Journal ◽

10.1093/eurheartj/ehy564.p813 ◽

2018 ◽

Vol 39 (suppl_1) ◽

Author(s):

W R Rzechorzek ◽

M R Rodriguez ◽

R D L V De La Villa ◽

A M Manguba ◽

D W Weininger ◽

...

Keyword(s):

Myocardial Infarction ◽

Pulmonary Disease ◽

Obstructive Pulmonary Disease ◽

St Segment Elevation ◽

Segment Elevation Myocardial Infarction ◽

St Segment

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Oral Corticosteroid Use and the Risk of Acute Myocardial Infarction in Chronic Obstructive Pulmonary Disease

Canadian Respiratory Journal ◽

10.1155/2006/935718 ◽

2006 ◽

Vol 13 (3) ◽

pp. 134-138 ◽

Cited By ~ 15

Author(s):

Laetitia Huiart ◽

Pierre Ernst ◽

Xavier Ranouil ◽

Samy Suissa

Keyword(s):

Myocardial Infarction ◽

Chronic Obstructive Pulmonary Disease ◽

Acute Myocardial Infarction ◽

Pulmonary Disease ◽

Systemic Hypertension ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Increased Risk ◽

Acute Exacerbations ◽

Oral Corticosteroids

BACKGROUND: Given the limited efficacy of oral corticosteroids in treating chronic obstructive pulmonary disease (COPD), the possible cardiac side effects of oral corticosteroids are of particular concern in an elderly population. The impact of the use of oral corticosteroids on the risk of acute myocardial infarction (AMI) in a cohort of patients with COPD was studied.METHODS: The Saskatchewan health services databases were used to form a population-based cohort of 5648 patients aged 55 years or older who received a first treatment for COPD between 1990 and 1997. A nested case-control analysis was conducted: 371 cases presenting with a first myocardial infarction were matched with 1864 controls according to the length of follow-up, the date of cohort entry and age. Conditional logistic regression was used to adjust for sex, severity of COPD, systemic hypertension, diabetes and prior cardiovascular disease.RESULTS: Only the current use of corticosteroids was associated with an increased risk of AMI (adjusted RR=2.01 [95% CI 1.13 to 3.58]), particularly when the current dose was larger than 25 mg/day of prednisone or the equivalent (adjusted RR=3.22 [95% CI 1.42 to 7.34]). This observed increase in risk rapidly returned to baseline after the cessation of the medication, suggesting that the use of such high doses reflected the treatment of acute exacerbations of the disease.CONCLUSIONS: An association was found between the current use of oral corticosteroids and the occurrence of an AMI, suggesting that acute exacerbations of COPD are associated with an increased risk of acute coronary syndromes.

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