6154Prospective study on the prognostic value of the repeated carotid intima-media thickness changes assessment in patients with coronary and extra-coronary steno-occlusive arterial disease

The study was aimed to define the predictors for peripheral and carotid revascularization in type 2 diabetic population. In all, 279 patients with type 2 diabetes and peripheral arterial disease were enrolled in a cohort longitudinal study. Study population was followed up for 24 months for the need and performance of peripheral or carotid revascularization. Logistic regression analysis was conducted to identify variables predictive of revascularization, when lipid plasma levels, glycemia, arterial hypertension, blood pressures, ankle-brachial index, intima-media thickness, body mass index, waist circumference, and hip distances were put in a model. Total cholesterol and maximal value of carotid intima-media thickness were presented as factors that independently influenced the performed peripheral revascularization. Waist circumference is defined as independent factor associated with carotid endarterectomy. Measurement of carotid intima-media thickness, waist circumference, and plasma lipid levels in type 2 diabetes with manifested peripheral and carotid arterial disease should be recommended in a manner of proper risk stratification of this population.

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Diagnostic and Prognostic Significance of miR-675-3p in Patients With Atherosclerosis

Clinical and Applied Thrombosis/Hemostasis ◽

10.1177/10760296211024754 ◽

2021 ◽

Vol 27 ◽

pp. 107602962110247

Author(s):

Shuangquan Wang ◽

Wei Shao ◽

Yang Gao ◽

Hongwei Zhao ◽

Deyong Du

Keyword(s):

Adverse Events ◽

Roc Curve ◽

Prognostic Value ◽

Cox Regression ◽

Prognostic Significance ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Value Assessment ◽

Cox Regression Analysis ◽

Media Thickness

In recent years, a rising number of studies have confirmed that microRNA (miRNA) plays a prominent role in the early diagnosis and prognostic value assessment of cardiovascular diseases. The current study was conducted to examine the expression of miR-675-3p in atherosclerosis (AS) patients and to evaluate its clinical diagnosis and prognostic value. 110 AS patients and 70 healthy controls were included in the study. Serum miR-675-3p levels were detected by quantitative real-time PCR (qRT-PCR). The clinical diagnostic significance of serum miR-675-3p in AS patients were investigated by the receiver operating characteristic (ROC) curve. The correlation between miRNA and carotid intima-media thickness (CIMT) was analyzed by the Spearman correlation coefficient. The prognostic significance of serum miR-675-3p was evaluated by the Kaplan-Meier method and Cox regression analysis. The patient’s serum miR-675-3p was significantly increased than the healthy individuals ( P < 0.05). An increase of carotid intima-media thickness (CIMT) was positively correlated with the promotion of serum miR-675-3p levels. The area under the ROC curve (AUC) was 0.918, with high sensitivity and specificity. miR-675-3p is a key independent predictor of cardiovascular adverse events in AS patients (HR = 5.375, 95%CI = 1.590-18.170, P = 0.007), and patients with elevated miR-675-3p were more likely to have cardiovascular adverse events (log-rank P = 0.030). Increased miR-675-3p can be used as a potential marker for the diagnosis of AS, and was associated with the poor prognosis of AS.

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