P3573Different contribution of sympathetic nerve activity to pulse wave velocity and arterial velocity pulse index in healthy subjects

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
H Sugimoto ◽  
H Murai ◽  
T Hamaoka ◽  
Y Mukai ◽  
O Inoue ◽  
...  
Keyword(s):  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Sympathetic Nerve ◽  
Healthy Subjects ◽  
Sympathetic Nerve Activity ◽  
Pulse Wave ◽  
Velocity Pulse ◽  
Nerve Activity ◽  
Reflected Wave ◽  
The Relationship

Abstract Background Pulse Wave Velocity (PWV) is associated with the net effect of arterial stiffness and sympathetic nerve activity. Recent study demonstrated the significant relationship between PWV and muscle sympathetic nerve activity (MSNA). Arterial Velocity pulse Index (AVI) is a newly developed parameter, which could evaluate vascular reflected wave, regardless of aortic form. Vascular reflected wave is considered to be associated with sympathetic nerve activity, however little is known about the relationship between AVI and MSNA. Purpose The purpose of this study was to evaluate the relationship between AVI or PWV and MSNA in healthy subject. Method 21 healthy subjects were included in this study. AVI was measured by NAS-1000 (Nihon Koden, Japan), calculated from the time series of occlusive cuff pressure in the left upper arm. Brachial-ankle PWV (baPWV) was measured by BP-203RPEIII (Omron Healthcare, Japan). MSNA was recorded from left peroneal nerve by microneurography using tungsten microelectrode. All measurements were performed in the same day morning. Results The mean age was 31+5 years and body mass index (BMI) 22.5+3.0 kg/m2. In regression analysis, baPWV was significantly associated with age (r=0.64 P<0.05) but not with MSNA or BMI. AVI was significantly associated with MSNA (r=0.73, P<0.05) but not with age and BMI. Conclusion We found that different contribution of MSNA to baPWV and AVI and revealed that AVI was associated with MSNA in healthy subjects. These results suggest that AVI could reflect sympathetic nerve activity compared to baPWV.

An independent relationship between muscle sympathetic nerve activity and pulse wave velocity in normal humans

2010 ◽  
Vol 28 (5) ◽  
pp. 979-984 ◽  
Author(s):  
Ewa Świerblewska ◽  
Dagmara Hering ◽  
Tomas Kara ◽  
Katarzyna Kunicka ◽  
Piotr Kruszewski ◽  
...  
Keyword(s):  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Pulse Wave ◽  
Muscle Sympathetic Nerve Activity ◽  
Nerve Activity ◽  
Normal Humans

scholarly journals Influence of sympathetic nerve activity on aortic hemodynamics and pulse wave velocity in women

2017 ◽  
Vol 312 (2) ◽  
pp. H340-H346 ◽  
Author(s):  
Ronée E. Harvey ◽  
Jill N. Barnes ◽  
Emma C. J. Hart ◽  
Wayne T. Nicholson ◽  
Michael J. Joyner ◽  
...  
Keyword(s):  
Pulse Wave Velocity ◽  
Postmenopausal Women ◽  
Young Women ◽  
Sympathetic Nerve ◽  
Sympathetic Activity ◽  
Sympathetic Nerve Activity ◽  
Pulse Wave ◽  
Nerve Activity ◽  
Ganglionic Blockade ◽  
Aortic Hemodynamics

Central (aortic) blood pressure, arterial stiffness, and sympathetic nerve activity increase with age in women. However, it is unknown if the age-related increase in sympathetic activity influences aortic hemodynamics and carotid-femoral pulse wave velocity (cfPWV), an index of central aortic stiffness. The goal of this study was to determine if aortic hemodynamics and cfPWV are directly influenced by sympathetic nerve activity by measuring aortic hemodynamics, cfPWV, and muscle sympathetic nerve activity (MSNA) in women before and during autonomic ganglionic blockade with trimethaphan camsylate. We studied 12 young premenopausal (23 ± 4 yr) and 12 older postmenopausal (57 ± 3 yr) women. These women did not differ in body mass index or mean arterial pressure ( P > 0.05 for both). At baseline, postmenopausal women had higher aortic pulse pressure, augmented pressure, augmentation index adjusted for a heart rate of 75 beats/min, wasted left ventricular pressure energy, and cfPWV than young women ( P < 0.05). During ganglionic blockade, postmenopausal women had a greater decrease in these variables in comparison to young women ( P < 0.05). Additionally, baseline MSNA was negatively correlated with the reductions in aortic pulse pressure, augmented pressure, and wasted left ventricular pressure energy during ganglionic blockade in postmenopausal women ( P < 0.05) but not young women. Baseline MSNA was not correlated with the changes in augmentation index adjusted for a heart rate of 75 beats/min or cfPWV in either group ( P > 0.05 for all). Our results suggest that some aortic hemodynamic parameters are influenced by sympathetic activity to a greater extent in older postmenopausal women than in young premenopausal women. NEW & NOTEWORTHY Autonomic ganglionic blockade results in significant decreases in multiple aortic pulse wave characteristics (e.g., augmented pressure) and central pulse wave velocity in older postmenopausal women but not in young premenopausal women. Certain aortic pulse wave parameters are negatively influenced by sympathetic activity to a greater extent in older postmenopausal women.

Abstract 16604: Significant Correlation Between Arterial Velocity Pulse Index and Muscle Sympathetic Nerve Activity in Hypertensive Patients

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
hiroyuki sugimoto ◽  
Hisayoshi Murai ◽  
Takuto Hamaoka ◽  
Yusuke Mukai ◽  
Yoshitaka Okabe ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Muscle Sympathetic Nerve Activity ◽  
Velocity Pulse ◽  
Nerve Activity ◽  
Control Subjects ◽  
Group 2 ◽  
The Relationship ◽  
Group 1

Introduction: Augmented sympathetic nerve activity (SNA) in hypertension (HT) is regarded as a therapeutic target, but there is few non-invasive markers to evaluate SNA in clinical practice. It is reported to associate with SNA which increased arterial reflected wave plays the important role in disease progression in HT, and it is reported to associate with SNA. Recently, Arterial Velocity Pulse Index (AVI) are developed as an index of arterial reflected waves, however the relationship between AVI and SNA is still uncertain. Methods: Patients with essential HT and matched non-hypertensive control subjects were included in this study. HT was diagnosed as systolic blood pressure (SBP) ≧ 140 mmHg or diastolic blood pressure (DBP) ≧ 90 mmHg. Patients with secondary HT was excluded. AVI was measured from left upper arm by NAS-1000 (Nihon Koden, Japan). SNA was evaluated by direct recording of muscle sympathetic nerve activity (MSNA) from peroneal nerves. Results: 50 HT patients and 50 control subjects were included. Age, SBP and DBP were significantly increased in HT group compared to control (Age 63±14 vs 42±16 years, p<0.001; SBP 144±16 vs 115±9 mmHg, p<0.001; DBP 80±14 vs 67±9 mmHg, p<0.001). MSNA and AVI were significantly increased in HT group compared to control (MSNA 34±10 vs 25±8 bursts/min, p<0.05; AVI 28±9 vs 17±5, p<0.05). In univariate analysis, AVI was significantly correlated with MSNA, age, and SBP in HT group. However, no significant relationship was observed between AVI and MSNA in multivariate analysis. Therefore, HT group was divided into two groups according to their severity (group 1, SBP<160mmHg, N=30; group 2, SBP>160 mmHg, N=20). AVI in group 1 showed significantly correlation with MSNA (r=0.49, p<0.05), but no correlation was seen in group 2. Conclusions: AVI was significantly increased in patients with HT compared to control, and AVI is significantly associated with MSNA in HT patients with SBP<160mmHg. These results indicate that AVI is helpful to estimate augmented SNA in patients with mild or moderate hypertension. Further study is warranted to exam the relationship AVI and SNA in reality.

scholarly journals Effects of an Innovative Head-Up Tilt Protocol on Blood Pressure and Arterial Stiffness Changes

2021 ◽  
Vol 10 (6) ◽  
pp. 1198
Author(s):  
Victor N. Dorogovtsev ◽  
Dmitry S. Yankevich ◽  
Nandu Goswami
Keyword(s):  
Blood Pressure ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Healthy Subjects ◽  
Pulse Wave ◽  
Task Force ◽  
Column Height ◽  
Tilt Test ◽  
Test Protocol ◽  
Head Up Tilt

The objective of our study was to identify blood pressure (BP) and pulse wave velocity (PWV) changes during orthostatic loading, using a new the head-up tilt test (HUTT), which incorporates the usage of a standardized hydrostatic column height. Methods: 40 healthy subjects 20–32 years performed HUTT, which was standardized to a height of the hydrostatic column at 133 cm. Exposure time was 10 min in each of 3 positions: horizontal supine 1, HUTT, and horizontal supine 2. The individual tilt up angle made it possible to set the standard value of the hydrostatic column. Hemodynamic parameters were recorded beat to beat using “Task Force Monitor 3040 i”, pulse-wave velocity (PWV) was measured with a sphygmograph–sphygmomanometer VaSera VS1500N. Results: Orthostatic loading caused a significant increase in heart rate (HR) and a decrease in stroke volume (SV) (p < 0.05) but no significant reductions in cardiac output, changes in total vascular resistance (TVR), or BP. An analysis of personalized data on systolic blood pressure (SBP) changes in tilt up position as compared to horizontal position (ΔSBP) revealed non-significant changes in this index in 48% of subjects (orthostatic normotension group), in 32% there was a significant decrease in it (orthostatic hypotension group) and in 20% there was a significant increase in it (orthostatic hypertension group). These orthostatic changes were not accompanied by any clinical symptoms and/or syncope. During HUTT, all subjects had in the PWV a significant increase of approximately 27% (p < 0.001). Conclusion: The new test protocol involving HUTT standardized to a height of hydrostatic column at 133 cm causes typical hemodynamics responses during orthostatic loading. Individual analysis of the subjects revealed subclinical orthostatic disorders (OSD) in up to 52% of the test persons. During HUTT, all test subjects showed a significant increase in PWV. The new innovative HUTT protocol can be applied in multi-center studies in healthy subjects to detect preclinical forms of orthostatic disorders under standard gravity load conditions.

The relationship between aortic augmentation index and pulse wave velocity: an invasive study

2007 ◽  
Vol 25 (2) ◽  
pp. 391-397 ◽  
Author(s):  
Masato Sakurai ◽  
Tetsu Yamakado ◽  
Hideshi Kurachi ◽  
Takaaki Kato ◽  
Kenji Kuroda ◽  
...  
Keyword(s):  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Augmentation Index ◽  
The Relationship
Sign in / Sign up

Export Citation Format

Share Document