scholarly journals Co-segregation of intermale aggression with the pseudoautosomal region of the Y chromosome in mice.

Genetics ◽  
1994 ◽  
Vol 136 (1) ◽  
pp. 225-230 ◽  
Author(s):  
P L Roubertoux ◽  
M Carlier ◽  
H Degrelle ◽  
M C Haas-Dupertuis ◽  
J Phillips ◽  
...  
Keyword(s):  
Sexual Dimorphism ◽  
Y Chromosome ◽  
Pseudoautosomal Region ◽  
Attack Behavior ◽  
Laboratory Mice ◽  
Conspecific Male ◽  
Intermale Aggression

Abstract The sexual dimorphism of aggression has led to a search for its Y chromosomal correlates. We have previously confirmed that initiation of attack behavior against a conspecific male is Y-dependent in two strains of laboratory mice (NZB and CBA/H). We provide evidence that the non-pseudoautosomal region of the Y is not involved and that only the pseudoautosomal region of the Y is correlated with initiation of attack behavior. The autosomal correlates also contribute to this behavior in an additive or interactive manner with the pseudoautosomal correlates.

scholarly journals The Y chromosome effect on intermale aggression in mice depends on the maternal environment.

Genetics ◽  
1991 ◽  
Vol 129 (1) ◽  
pp. 231-236
Author(s):  
M Carlier ◽  
P L Roubertoux ◽  
C Pastoret
Keyword(s):  
Y Chromosome ◽  
Maternal Effect ◽  
Attack Behavior ◽  
Laboratory Mice ◽  
Maternal Environment ◽  
Intermale Aggression ◽  
Ovarian Graft

Abstract Two parental strains of laboratory mice, NZB and CBA/H, were chosen for their differences in attack behavior. NZB have higher scores than CBA/H. An effect of the Y chromosome on attack behavior was determined for two maternal environments. Each male was tested once in a dyadic encounter with an A/J male as a standard opponent. The two reciprocal F1s and the four reciprocal backcrosses were used. In each group, the proportion of attacking males was used as the dependent variable. In the first experiment, the ovarian graft method was used to test for an effect of variation of the overall maternal environment: parental vs. F1. The results demonstrated an interaction between the Y chromosome and the maternal environment. By use of the adoption method, it was shown in the second experiment that this maternal effect was probably postnatal (and not prenatal).

scholarly journals Cutting Edge: The Y Chromosome Controls the Age-Dependent Experimental Allergic Encephalomyelitis Sexual Dimorphism in SJL/J Mice

2009 ◽  
Vol 182 (4) ◽  
pp. 1789-1793 ◽  
Author(s):  
Karen M. Spach ◽  
Melissa Blake ◽  
Janice Y. Bunn ◽  
Ben McElvany ◽  
Rajkumar Noubade ◽  
...  
Keyword(s):  
Sexual Dimorphism ◽  
Y Chromosome ◽  
Experimental Allergic Encephalomyelitis ◽  
Cutting Edge ◽  
Allergic Encephalomyelitis ◽  
Age Dependent ◽  
Experimental Allergic

scholarly journals Meiotic Behavior of Achiasmate Sex Chromosomes in the African Pygmy Mouse Mus mattheyi Offers New Insights into the Evolution of Sex Chromosome Pairing and Segregation in Mammals

Genes ◽  
2021 ◽  
Vol 12 (9) ◽  
pp. 1434
Author(s):  
Ana Gil-Fernández ◽  
Marta Ribagorda ◽  
Marta Martín-Ruiz ◽  
Pablo López-Jiménez ◽  
Tamara Laguna ◽  
...  
Keyword(s):  
Dna Repair ◽  
Y Chromosome ◽  
Sex Chromosomes ◽  
Sex Chromosome ◽  
Mammalian Species ◽  
Evolutionary Process ◽  
Small Region ◽  
Pseudoautosomal Region ◽  
Evolution Of Sex ◽  
African Pygmy Mouse

X and Y chromosomes in mammals are different in size and gene content due to an evolutionary process of differentiation and degeneration of the Y chromosome. Nevertheless, these chromosomes usually share a small region of homology, the pseudoautosomal region (PAR), which allows them to perform a partial synapsis and undergo reciprocal recombination during meiosis, which ensures their segregation. However, in some mammalian species the PAR has been lost, which challenges the pairing and segregation of sex chromosomes in meiosis. The African pygmy mouse Mus mattheyi shows completely differentiated sex chromosomes, representing an uncommon evolutionary situation among mouse species. We have performed a detailed analysis of the location of proteins involved in synaptonemal complex assembly (SYCP3), recombination (RPA, RAD51 and MLH1) and sex chromosome inactivation (γH2AX) in this species. We found that neither synapsis nor chiasmata are found between sex chromosomes and their pairing is notably delayed compared to autosomes. Interestingly, the Y chromosome only incorporates RPA and RAD51 in a reduced fraction of spermatocytes, indicating a particular DNA repair dynamic on this chromosome. The analysis of segregation revealed that sex chromosomes are associated until metaphase-I just by a chromatin contact. Unexpectedly, both sex chromosomes remain labelled with γH2AX during first meiotic division. This chromatin contact is probably enough to maintain sex chromosome association up to anaphase-I and, therefore, could be relevant to ensure their reductional segregation. The results presented suggest that the regulation of both DNA repair and epigenetic modifications in the sex chromosomes can have a great impact on the divergence of sex chromosomes and their proper transmission, widening our understanding on the relationship between meiosis and the evolution of sex chromosomes in mammals.

scholarly journals A Short Pseudoautosomal Region in Laboratory Mice

2001 ◽  
Vol 11 (11) ◽  
pp. 1826-1832 ◽  
Author(s):  
Jo Perry ◽  
Steve Palmer ◽  
Anastasia Gabriel ◽  
Alan Ashworth
Keyword(s):  
Pseudoautosomal Region ◽  
Laboratory Mice

Genetic Content of the Neo-Sex Chromosomes in Ctenonotus and Norops (Squamata, Dactyloidae) and Degeneration of the Y Chromosome as Revealed by High-Throughput Sequencing of Individual Chromosomes

2019 ◽  
Vol 157 (1-2) ◽  
pp. 115-122 ◽  
Author(s):  
Artem P. Lisachov ◽  
Alexey I. Makunin ◽  
Massimo Giovannotti ◽  
Jorge C. Pereira ◽  
Anna S. Druzhkova ◽  
...  
Keyword(s):  
Y Chromosome ◽  
X Chromosome ◽  
High Throughput ◽  
Sex Chromosomes ◽  
High Throughput Sequencing ◽  
Anolis Carolinensis ◽  
Pseudoautosomal Region ◽  
Central Component ◽  
Similar System ◽  
Divergence Estimates

Pleurodont lizards are characterized by an ancient system of sex chromosomes. Along with stability of the central component of the system (homologous to the X chromosome of Anolis carolinensis [Dactyloidae], ACAX), in some genera the ancestral sex chromosomes are fused with microautosomes, forming neo-sex chromosomes. The genus Ctenonotus (Dactyloidae) is characterized by multiple X1X1X2X2/X1X2Y sex chromosomes. According to cytogenetic data, the large neo-Y chromosome is formed by fusion of the ancestral Y chromosome with 2 microautosomes (homologous to ACA10 or ACA11 and ACA12), the X1 chromosome is formed by fusion of the ancestral X chromosome with the autosome homologous to ACA10 or ACA11, and the X2 chromosome is homologous to autosome ACA12. To determine more precisely the content and evolution of the Ctenonotus sex chromosomes, we sequenced flow-sorted chromosomes (both sex chromosomes and microautosomes as control) of 2 species with a similar system: C. pogus and C. sabanus. Our results indicate that the translocated part of the X1 is homologous to ACA11, X2 is homologous to ACA12, and the Y contains segments homologous to both ACA11 and ACA12. Molecular divergence estimates suggest that the ancestral X-derived part has completely degenerated in the Y of Ctenonotus, similar to the degeneration of the Norops sagrei Y chromosome (Dactyloidae). The newly added regions show loss of DNA content, but without degeneration of the conserved regions. We hypothesize that the translocation of autosomal blocks onto sex chromosomes facilitated rapid degeneration of the pseudoautosomal region on the ancestral Y.

X-Y chromosome dissociation in wild derived Mus musculus subspecies, laboratory mice, and their Fi hybrids

1982 ◽  
Vol 34 (3) ◽  
pp. 241-252 ◽  
Author(s):  
Y. Matsuda ◽  
H.T. Imai ◽  
K. Moriwaki ◽  
K. Kondo ◽  
F. Bonhomme
Keyword(s):  
Y Chromosome ◽  
Mus Musculus ◽  
Laboratory Mice
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