INVESTIGATIONS ON THE PROBLEM OF METAMORPHOSIS. V. SOME FACTORS DETERMINING THE FACET NUMBER IN THE DROSOPHILA MUTANT BAR

Abstract Remarkably little is known about the molecular mechanisms that drive sexual behavior. We have identified a new gene, quick-to-court (qtc), whose mutations cause males to show high levels of male-male courtship. qtc males also show a novel phenotype: when placed in the presence of a virgin female, they begin courtship abnormally quickly. qtc mutations are striking in their specificity, in that many aspects of male sexual behavior are normal. We have cloned the qtc gene and found that it encodes a predicted coiled-coil protein and is expressed in the olfactory organs, central nervous system, and male reproductive tract.

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A CHANGE IN THE BAR GENE OF DROSOPHILA INVOLVING FURTHER DECREASE IN FACET NUMBER AND INCREASE IN DOMINANCE

The Journal of General Physiology ◽

10.1085/jgp.2.1.69 ◽

1919 ◽

Vol 2 (1) ◽

pp. 69-71 ◽

Cited By ~ 9

Author(s):

Charles Zeleny

Keyword(s):

Bar Gene ◽

Facet Number

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PARTIAL “SWEET TASTE BLINDNESS” AND CONFIGURATIONAL REQUIREMENT OF STIMULANTS IN A DROSOPHILA MUTANT

The Japanese Journal of Genetics ◽

10.1266/jjg.53.71 ◽

1978 ◽

Vol 53 (1) ◽

pp. 71-73 ◽

Cited By ~ 4

Author(s):

TEIICHI TANIMURA ◽

KUNIO ISONO ◽

TOSHIHIDE KIKUCHI

Keyword(s):

Sweet Taste ◽

Drosophila Mutant

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Identification and mapping of human cDNAs homologous to Drosophila mutant genes through EST database searching

Trends in Genetics ◽

10.1016/0168-9525(96)81477-6 ◽

1996 ◽

Vol 12 (9) ◽

pp. 344

Author(s):

S Banfi

Keyword(s):

Database Searching ◽

Est Database ◽

Mutant Genes ◽

Drosophila Mutant

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Royal jelly attenuates metabolic defects in a Drosophila mutant with elevated TORC1 activity

Biology Open ◽

10.1242/bio.054999 ◽

2020 ◽

Vol 9 (11) ◽

pp. bio054999

Author(s):

Yang Cheng ◽

Jiadong Cai ◽

Yuanyuan Fu ◽

Congjing Feng ◽

Yue Hao ◽

...

Keyword(s):

Royal Jelly ◽

Cell Metabolism ◽

Health Benefit ◽

Caste Differentiation ◽

Energy Status ◽

Metabolic Defects ◽

Age Related ◽

Essential Components ◽

Drosophila Mutant

ABSTRACTTarget of rapamycin complex 1 (TORC1) is a master regulator of cell metabolism, and its dysregulation has been linked to an array of pathologies, including cancer and age-related diseases. Nprl3, a component of GTPase-activating protein towards Rags complex 1 (GATOR1), inhibits TORC1 activity under nutrient scarcity status. The nprl3 mutant exhibits some metabolic defects due to hyper TORC1 activity in Drosophila. Royal jelly (RJ) is a honeybee-secreted product and plays an essential role in caste differentiation that requires TORC1 activity. RJ is also used as a health-benefit food for its potential roles on antioxidant and anti-aging. In this study, nprl3-mutant flies were used to measure the effect of RJ on metabolic modulation. Interestingly, RJ feeding significantly increased survival and decreased TORC1 activity in the nprl3 mutant. RJ feeding also ameliorated the abnormal reactive oxygen species (ROS) levels and energy status in the nprl3 mutant. The proteins in RJ were characterized to be the essential components in increasing nprl3 mutant viability. These findings suggest that RJ modulates some metabolic defects associated with elevated TORC1 activity and that the nprl3-mutant fly might be a useful tool for investigating the bioactive components of RJ in vivo.

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