Inverse Susceptibility to Oxidative Death of Lymphocytes Obtained From Alzheimer's Patients and Skin Cancer Survivors: Increased Apoptosis in Alzheimer's and Reduced Necrosis in Cancer

Abstract Introduction Sleep disturbances are a common problem among cancer survivors. Also, cancer patients can have altered circadian rhythms and these changes can continue to affect the patient long after the conclusion of their treatment. This analysis aims to investigate how the sleep and wake times of cancer survivors differ from the rest of the population, depending on the type of cancer. Methods Data from the 2015-2016 National Health and Nutrition Examination Survey were used. Population-weighted data on N=5,581 individuals provided complete data. History of breast, prostate, and skin cancer (melanoma or other) was self-reported. Sleep duration was self-reported in half-hour increments, and typical bedtime and waketime was self-reported. Covariates included age, sex, and race/ethnicity. Weighted linear regressions with sleep duration, bedtime and waketime were examined, with each cancer type as predictor. Results Prevalence was 1.7% for prostate cancer, 1.5% for breast cancer, 2.3% for non-melanoma skin cancer, and 0.8% for melanoma. In adjusted analyses, prostate cancer was associated with an additional 26.5 minutes of average total sleep (95%CI 2.2,50.9, p=0.03), a 23.1 bedtime minutes earlier (95%CI -40.4,-5.8, p=0.009), and no difference in waketime. Breast cancer was associated with a bedtime that was 41.1 minutes later (95%CI 10.3,72.0, p=0.009) and a waketime that was 48.7 minutes later (95%CI 12.5,84.9, p=0.008), but no difference in sleep duration. No statistically significant effects were seen for either type of skin cancer, melanoma or non-melanoma. Conclusion Prostate cancer was associated with an earlier bedtime and associated increased sleep time. Breast cancer, on the other hand, was associated with a phase delay of the sleep period but no change in sleep duration. Skin cancer was not associated with differences in sleep duration or timing. These findings may have implications for not only treatment of sleep problems in different types of cancer, but also possible circadian mechanisms. Support Dr. Grandner is supported by R01MD011600

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Need For Improved Skin Cancer Surveillance in Pediatric Cancer Survivors

American Journal of Clinical Dermatology ◽

10.1007/s40257-016-0241-1 ◽

2016 ◽

Vol 18 (2) ◽

pp. 165-168 ◽

Cited By ~ 2

Author(s):

Divya Sharma ◽

Thomas Lee ◽

Adam J. Friedman ◽

Kelley Pagliai Redbord

Keyword(s):

Skin Cancer ◽

Cancer Survivors ◽

Pediatric Cancer ◽

Cancer Surveillance ◽

Pediatric Cancer Survivors

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Association of Sociodemographics with Out-of-Pocket Expenditure and Underinsurance in Skin Cancer Survivors

10.1101/2021.07.17.21251600 ◽

2021 ◽

Author(s):

Mohammad A. Karim ◽

Robert L. Ohsfeldt ◽

Nima Khodakarami ◽

Hye-Chung Kum

Keyword(s):

Skin Cancer ◽

Cancer Survivors ◽

Private Insurance ◽

College Education ◽

Medical Expenditure ◽

Reference Level ◽

Lower Probability ◽

Marginal Effect ◽

Poverty Level ◽

Sociodemographic Predictors

Background: The sociodemographic predictors of either out-of-pocket expenditure (OOP) or underinsurance among skin cancer survivors is not well reported in the literature. In this study we estimated all-cause healthcare related OOP expenditure and probability of underinsurance among insured skin cancer survivors and identified the sociodemographic predictors of these measures. Data and Method: We pooled Medical Expenditure Panel Survey (MEPS) data from 2011 to 2015 and identified skin cancer using Clinical Classifications Software (CCS) code. Only adult (≥18 years) skin cancer survivors with full year insurance coverage were included in our study (n = 1825). We used a generalized linear model (GLM) with log link and gamma distribution to estimate OOP and a logit model to estimate the probability of underinsurance. We estimated the Average Marginal Effect (AME) to quantify the variations and their statistical significance between reference level and other levels of each predictor. Our analyses accounted for the complex survey design of MEPS. Results: The average all-cause OOP was $1766 per person per year for a skin cancer survivor. Among all skin cancer survivors, females, those aged 60-64 years, with some college education or a degree, with income ≥400% of federal poverty level (FPL) and with non-managed-care private insurance incurred significantly higher OOP expenditure compared to their respective counterparts. In terms of underinsurance, females and those aged 60-64 years had higher probability, whereas, survivors with non-white race/ethnicity and income 200% of FPL or higher had lower probability of being underinsured compared to their respective counterparts. Conclusion: Our study demonstrates that OOP expenditure and underinsurance varies significantly by sociodemographic factors among skin cancer survivors.

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The Time Has Come to Enhance Skin Cancer Screening for Adult Childhood Cancer Survivors

JNCI Journal of the National Cancer Institute ◽

10.1093/jnci/djy213 ◽

2019 ◽

Vol 111 (8) ◽

pp. 760-761

Author(s):

Alan C Geller ◽

Karen M Emmons

Keyword(s):

Cancer Screening ◽

Skin Cancer ◽

Cancer Survivors ◽

Childhood Cancer ◽

Childhood Cancer Survivors ◽

Skin Cancer Screening

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Skin Cancer Risk Among Testicular Germ‐Cell Cancer Survivors: A Systematic Review and Meta‐Analysis

Journal of the European Academy of Dermatology and Venereology ◽

10.1111/jdv.17932 ◽

2022 ◽

Author(s):

Ofer Reiter ◽

Vanessa B. Voss ◽

Ronen Fluss ◽

Lindsay M. Boyce ◽

Jennifer L. DeFazio ◽

...

Keyword(s):

Systematic Review ◽

Skin Cancer ◽

Cancer Risk ◽

Cancer Survivors ◽

Germ Cell ◽

Meta Analysis ◽

Cell Cancer ◽

Germ Cell Cancer ◽

Testicular Germ Cell ◽

Testicular Germ Cell Cancer

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Impact of Depression on Health-Related Quality of Life among Skin Cancer Survivors

SKIN The Journal of Cutaneous Medicine ◽

10.25251/skin.3.6.3 ◽

2019 ◽

Vol 3 (6) ◽

pp. 381-394

Author(s):

Kaustuv Bhattacharya ◽

Namita Joshi ◽

Ruchit Shah ◽

Vinayak K. Nahar

Keyword(s):

Skin Cancer ◽

Cancer Survivors ◽

Activity Limitations ◽

General Health Status ◽

Comorbid Depression ◽

Related Quality ◽

Health Related ◽

Nationally Representative ◽

The Relationship

Introduction: Skin cancers are one of the most common cancers in the United States (US). Studies have reported depression to be a common comorbid condition among individuals with skin cancer. This study aimed to evaluate the relationship of depression with health-related quality of life (HRQOL) among individuals with a skin cancer diagnosis.Methods: A cross-sectional study design using the 2017 Behavioral Risk Factor Surveillance System (BRFSS) data, a nationally representative sample of non-institutionalized US adults, was utilized for the study. Multivariable logistic regression was used to assess the relationship between depression and the HRQOL domains (general health status, physical health, mental health, and activity limitations due to poor physical or mental health) among survivors of skin cancer.Results: Comorbid depression was identified in 20% of skin cancer survivors. After adjusting for covariates, skin cancer survivors with depression had higher odds of having poor general health status (Odds Ratio [OR] = 1.67, 95% Confidence Interval [CI] 1.41-1.98) as compared to skin cancer survivors without depression. Skin cancer survivors with depression also had greater odds of having poor physical HRQOL (OR = 1.82, 95% CI 1.53-2.15), poor mental HRQOL (OR = 6.38, 95% CI 5.26-7.74), and activity limitations (OR = 2.42, 95% CI 2.03-2.89) as compared to those without depression.Conclusion: This study highlights the significant negative impact of comorbid depression on HRQOL in a nationally representative sample of skin cancer survivors, and serves as evidence for the need for more active surveillance and management of depression in this population.

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Prevalence and Age-Related Patterns in Health Information Seeking Behaviors and Technology Use Among Skin Cancer Survivors: Survey Study (Preprint)

10.2196/preprints.36256 ◽

2022 ◽

Author(s):

Michael Armando Marchetti ◽

Liliane Sar-Graycar ◽

Stephen W Dusza ◽

Japbani K Nanda ◽

Nicholas Kurtansky ◽

...

Keyword(s):

Skin Cancer ◽

Cancer Survivors ◽

Health Information ◽

Technology Use ◽

Information Seeking ◽

Unmet Need ◽

Population Based ◽

Health Information Seeking ◽

Age Related ◽

Information Seeking Behaviors

BACKGROUND Information is an unmet need among cancer survivors. There is a paucity of population-based data examining the health information seeking behaviors and attitudes of skin cancer survivors (SCSs). OBJECTIVE To identify prevalence and patterns of health information seeking behaviors and attitudes among SCSs across age groups. METHODS Analysis of National Cancer Institute population-based 2019 Health Information National Trends Survey 5, Cycle 3. RESULTS The 5438 respondents included 346 (6.4%) SCSs. Skin cancer respondents had a mean age of 65.8; the majority were white (96%, and 171 were men (48%). Most reported having ever looked for health (86%) or cancer (77%) information; 28% stated their last search took a lot of effort and 22% were frustrated. The internet was most often cited as being the first source that was recently used for health or medical information (46%). Compared to SCSs <65 years old, those ≥65 years of age were more likely to see a doctor first for important health information (68% vs. 36%, p<0.001) and less likely to have health/wellness apps (26% vs. 65%, p=0.1), to have watched a health-related YouTube video (13% vs. 27%, p=0.02), and to have used electronic means to look for information (61% vs. 82%, p<0.001) CONCLUSIONS Health information searches are common among SCSs, but behaviors and attitudes are associated with age, highlighting the importance of access to doctors and personalized information sources.

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