P–493 Couples joint narratives of coping with and making sense of recurrent pregnancy loss: a dyadic interview study

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
E Koert ◽  
H S Nielsen ◽  
L Schmidt

Abstract Study question What are couples’ joint narratives of coping with, and making sense of recurrent pregnancy loss? Summary answer Couples can become stuck in patterns of communication and coping roles that may be dissatisfying and not reflect the complexity of their experience of RPL. What is known already Fertility problems such as recurrent pregnancy loss (RPL) are unique health issues because they are a couple problem, in that they involve a blocked parenthood goal for both members of the couple regardless of the cause or source of the fertility issue. Previous research has focused on the psychosocial impact on the individual or examined gender differences in men and women’s response to RPL. Research suggests that couples’ relationships are impacted, but few examine this issue in interviews with couples as participants. We need appropriate study designs to examine and understand the couple’s experience and process on a dyadic level. Study design, size, duration This was a qualitative study using dyadic interviews and analysis. This method facilitates a co-construction of meaning and joint narrative between couples through sharing and comparing their experience in a conjoint dyadic interview. Thirteen couples who were referred to the RPL program, in Rigshospitalet, Copenhagen, Denmark were interviewed over a two-month period in 2017–2018. Interviews were held at Rigshospitalet and ranged between 81 and 109 minutes (average 91 minutes). Participants/materials, setting, methods: Inclusion criteria included: heterosexual couples with at least three pregnancy losses (PL) under 12 weeks gestation with no children/one child and willing to be interviewed in English. Thirty invitations were sent to couples who met the inclusion criteria and 15 couples contacted the interviewer to schedule an interview. Semi-structured dyadic interviews were conducted in person with 13 couples. Data was analyzed using dyadic analysis with a focus on common themes in co-constructed meaning across couples. Main results and the role of chance On average, participants had been in their relationship for 8.4 years, experienced three PLs (range three–six), with most recent PL occurring 4.3 months before the interview. Couples described becoming stuck in patterns of communication and in rigid roles of coping and relating (e.g., the optimist, the emotional one) that could be dissatisfying and not meet their needs and not reflect the nuances and complexity of their experience of RPL. Common roles included the “optimist” versus the “pessimist”, the “talker” versus the “listener” and the “emotional” versus the “rational / problem solver”. While these roles were rooted in some truth of their experience, the rigidity of these roles did not create space and flexibility for the full spectrum of their reactions and experience. For example, a woman said, “I hope for him to be the pessimist so I get to be the optimist sometimes” and several men shared the depth of their grief for the first time. The interviews were a way to highlight and create a new dynamic by allowing couples to respond to and correct their partner’s assumptions about their experience or role (e.g., “that’s not how I feel all the time”) and try new ways of communicating. Limitations, reasons for caution The findings cannot be generalized to all couples who have experienced RPL given the study design. Whilst dyadic interviews allow for a fuller, more nuanced narrative account, couples may omit some of their experience in the interview due to social desirability. Wider implications of the findings: This study provides a better understanding of the complexity of communication patterns and roles in couples with RPL that can improve provision of support and counselling. Dyadic interviews can provide opportunities for couples to communicate differently and break out of dissatisfying patterns while creating common ground and generating shared meaning. Trial registration number N/A

2009 ◽  
Vol 36 (2) ◽  
pp. 279-287 ◽  
Author(s):  
CARL A. LASKIN ◽  
KAREN A. SPITZER ◽  
CHRISTINE A. CLARK ◽  
MARK R. CROWTHER ◽  
JEFF S. GINSBERG ◽  
...  

Objective.To compare live birth rates in women with recurrent pregnancy loss (RPL) and either autoantibodies or a coagulation abnormality, treated with low molecular weight heparin plus aspirin (LMWH/ASA) or ASA alone, and to place our results in context with other randomized clinical trials (RCT) with similar cohorts.Methods.The HepASA Trial was an RCT including patients with a history of RPL and at least 1 of the following: antiphospholipid antibody (aPL), an inherited thrombophilia, or antinuclear antibody. Treatment groups were stratified by aPL status and history of early versus late pregnancy losses. Patients received either LMWH/ASA or ASA alone. The primary outcome was live birth; secondary outcomes included adverse events and bone loss at the spine and femoral neck. Literature over the past 20 years was reviewed to identify comparable RCT.Results.Over 4 years, 859 women with RPL were screened: 88 (10.2%) fulfilled inclusion criteria, became pregnant and were randomized to receive either LMWH/ASA or ASA alone. aPL were present in 42 (47.7%) patients in each group. The trial was stopped after 4 years when an interim analysis showed no difference in live birth rates in the 2 groups, and a lower rate of pregnancy loss in the ASA only group than expected. In the LMWH/ASA group, 35/45 (77.8%) had a live birth versus 34/43 (79.1%) in the ASA only group (p = 0.71). Neither number of prior losses nor aPL status was correlated with pregnancy outcome. There were no cases of pregnancy related thrombosis in either group. Mean change in BMD did not differ by treatment group at either the lumbar spine (p = 0.57) or femoral neck (p = 0.15). RCT since 2000 for aPL positive women with RPL and similar inclusion criteria report a mean live birth rate of 75% with either LMWH or ASA.Conclusion.LMWH/ASA did not confer incremental benefit compared to ASA alone for this population. Regardless of treatment regimen, number of prior losses, or aPL positivity, almost 80% of women in our RPL cohort had a successful pregnancy outcome. These findings contribute to a growing body of literature that contests the emerging standard of care comprising LMWH/ASA for this population.


Blood ◽  
2016 ◽  
Vol 127 (13) ◽  
pp. 1650-1655 ◽  
Author(s):  
Leslie Skeith ◽  
Marc Carrier ◽  
Risto Kaaja ◽  
Ida Martinelli ◽  
David Petroff ◽  
...  

Abstract We performed a meta-analysis of randomized controlled trials comparing low-molecular-weight heparin (LMWH) vs no LMWH in women with inherited thrombophilia and prior late (≥10 weeks) or recurrent early (<10 weeks) pregnancy loss. Eight trials and 483 patients met our inclusion criteria. There was no significant difference in livebirth rates with the use of LMWH compared with no LMWH (relative risk, 0.81; 95% confidence interval, 0.55-1.19; P = .28), suggesting no benefit of LMWH in preventing recurrent pregnancy loss in women with inherited thrombophilia.


Author(s):  
Sofie Bliddal ◽  
Nielsen Henriette Svarre ◽  
Aase Krogh-Rasmussen ◽  
Kolte Astrid Marie ◽  
Christiansen Ole Bjarne ◽  
...  

2019 ◽  
Vol 87 (March) ◽  
pp. 195-199
Author(s):  
MAHMOUD F. MAHDIA, M.Sc. TAREK M. EL-HAWARY, M.D. ◽  
SHAHENAZ H. EL-SHORBAGY, M.D. NAREMAAN M. EL-HAMAMY, M.D.

Gene ◽  
2021 ◽  
Vol 768 ◽  
pp. 145334
Author(s):  
Deeba S. Jairajpuri ◽  
Zainab H. Malalla ◽  
Naeema Mahmood ◽  
Farah Khan ◽  
Wassim Y. Almawi

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