Thyroid peroxidase antibodies do not predict outcome in 900 women with recurrent pregnancy loss

2017 ◽  
Author(s):  
Sofie Bliddal ◽  
Nielsen Henriette Svarre ◽  
Aase Krogh-Rasmussen ◽  
Kolte Astrid Marie ◽  
Christiansen Ole Bjarne ◽  
...  
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Thyroid Peroxidase ◽  
Thyroid Peroxidase Antibodies

Thyroid Peroxidase Antibodies and Prospective Live Birth Rate: A Cohort Study of Women with Recurrent Pregnancy Loss

Thyroid ◽  
2019 ◽  
Vol 29 (10) ◽  
pp. 1465-1474 ◽  
Author(s):  
Sofie Bliddal ◽  
Ulla Feldt-Rasmussen ◽  
Åse Krogh Rasmussen ◽  
Astrid Marie Kolte ◽  
Linda Marie Hilsted ◽  
...  
Keyword(s):  
Cohort Study ◽  
Live Birth ◽  
Pregnancy Loss ◽  
Birth Rate ◽  
Recurrent Pregnancy Loss ◽  
Live Birth Rate ◽  
Thyroid Peroxidase ◽  
Thyroid Peroxidase Antibodies

scholarly journals Prevalence of Thyroid Autoimmunity in Women with Recurrent Pregnancy Loss

Medicina ◽  
2021 ◽  
Vol 57 (2) ◽  
pp. 96
Author(s):  
Myrna Souraye Godines-Enriquez ◽  
Silvia Miranda-Velásquez ◽  
María Magdalena Enríquez-Pérez ◽  
Lidia Arce-Sánchez ◽  
Nayeli Martínez-Cruz ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Thyroid Autoimmunity ◽  
Cross Sectional Study ◽  
Thyroid Peroxidase ◽  
Cross Sectional ◽  
Increased Risk ◽  
Significant Difference ◽  
Thyroid Profile

Background and objectives: Thyroid autoimmunity (TAI) has been associated with a significantly increased risk of miscarriage in women with recurrent pregnancy loss (RPL). The aim of this study was to determine the prevalence of TAI in women with RPL and compare the clinical characteristics of positive and negative TAI women. Materials and Methods: This is a retrospective cross-sectional study; 203 women with RPL were included. Thyroid profile, anti-thyroid peroxidase (TPO-Ab), and anti-thyroglobulin (TG-Ab) antibodies were measured in all participants. Clinical characteristics and causes of RPL were compared between positive and negative TAI. Results: Prevalence of TAI was 14.8%; prevalence of positive TPO-Ab and TG-Ab was 12.3% and 4.9%, respectively. Women with TAI had significantly higher concentrations of thyrotropin (TSH) compared to women without TAI (4.8 ± 3.8 versus 3.1 ± 1.1, p = 0.001). There was no significant difference in age, the number of gestations, miscarriages, state of antiphospholipid antibodies (aPL), or causes of RPL between women that were TAI-positive versus TAI-negative. Prevalence of positive TAI by cause of RPL was: endocrine 7/25 (28%), genetic 1/5 (20%), autoimmune 1/5 (20%), anatomic 8/55 (14.5%), and unexplained cause 13/112 (11.6%). Conclusions: The prevalence of TAI in women with RPL is 14.8%. Women with an endocrine cause have the highest prevalence of TAI.

scholarly journals Peri conceptional association of the triad of hyperhomocsteinemia, hypothyroidism and impaired carbohydrate metabolism with recurrent pregnancy loss

2021 ◽  
Vol 10 (9) ◽  
pp. 3549
Author(s):  
Bhagyashree Mallinath Gadwal ◽  
Revathi S. Rajan ◽  
Kamini A. Rao
Keyword(s):  
Carbohydrate Metabolism ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Early Recognition ◽  
Thyroid Peroxidase ◽  
Thyroid Peroxidase Antibody ◽  
Two Factors ◽  
Potential Risk Factors ◽  
Hospital Protocols ◽  
Antibody Tests

Background: Recurrent pregnancy loss is a cause of great concern to the affected couple as well as the treating physician. We evaluated the periconceptional association of the triad of hyperhomocystienemia, hypothyroidism, and impaired carbohydrate metabolism with RPL and to identify the potential risk factors for RPL which are probably nutritional.Methods: Seven hundred ninety-six consecutive pregnancies with two or more abortions referring to our Infertility clinic were selected to be studied in a descriptive, prospective observational study in 2012-2014. All the pregnant women were subjected to routine blood tests/ examination/ imaging as per hospital protocols. All underwent TSH, FT4, GTT 75 gm (fasting and 2 h postprandial) as per routine antenatal workup. Additionally, fasting plasma homocysteine, antinuclear antibody, anti phospholipid antibody, anti- thyroid peroxidase antibody tests were performed for patients with RPL. All the patients were studied for the triad of hypothyroidism, hyperhomocysteinemia and impaired carbohydrate metabolism.Results: The incidence of RPL was found to be 5.65 %. Majority of women (51.1%) were in the age group 30-34 years. Majority of the women (55.6%) had 2 previous abortions. Majority of women (57.7%) had conceived normally. Majority of women (46.7%) had BMI<25. PCOS was reported in 28.9% women. HHcy, hypothyroidism and impaired carbohydrate metabolism was found in 78%, 73% and 73% women, respectively. The presence of two factors was reported in 60 to 65% women. 56% women reported the presence of the triad. About 7% of the patients underwent repeat abortion in second trimester of which 66.6% had the association of triad.Conclusions: Investigating these three factors in patients with RPL would help in early recognition, monitoring, and aggressive surveillance, which will help prevent obstetric complications. Simple nutritional correction may allow for better maternal and fetal programming and appropriate risk modulation.

Prophylactic Measures in Early Recurrent Pregnancy Loss in Women with Polycystic Ovary Syndrome and Hyperhomocysteinemia

2019 ◽  
Vol 87 (March) ◽  
pp. 195-199
Author(s):  
MAHMOUD F. MAHDIA, M.Sc. TAREK M. EL-HAWARY, M.D. ◽  
SHAHENAZ H. EL-SHORBAGY, M.D. NAREMAAN M. EL-HAMAMY, M.D.
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Prophylactic Measures
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