scholarly journals Challenges in IBD Research: Novel Technologies

2019 ◽  
Vol 25 (Supplement_2) ◽  
pp. S24-S30 ◽  
Author(s):  
Manish Dhyani ◽  
Nitin Joshi ◽  
Willem A Bemelman ◽  
Michael S Gee ◽  
Vijay Yajnik ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Treatment Response ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Septic Complications ◽  
Novel Technologies ◽  
Non Invasive ◽  
Targeted Drug ◽  
Active Inflammation ◽  
Targeted Drug Delivery Systems

This section is focused on prioritizing unmet clinical needs that will benefit from novel technologies applied to non-invasive detection and monitoring of active inflammation and assessment of treatment response, mucosal targeted drug delivery systems, and prevention of post-operative septic complications and treatment of fistulizing complications.

scholarly journals Polysaccharide-Based Nanoparticles for Colon-Targeted Drug Delivery Systems

2021 ◽  
Vol 2 (3) ◽  
pp. 626-647
Author(s):  
Yubia De Anda-Flores ◽  
Elizabeth Carvajal-Millan ◽  
Alma Campa-Mada ◽  
Jaime Lizardi-Mendoza ◽  
Agustin Rascon-Chu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Gi Tract ◽  
Colonic Delivery ◽  
Drug Degradation ◽  
Non Invasive ◽  
Targeted Drug ◽  
Targeted Drug Delivery Systems

Polysaccharide biomaterials have gained significant importance in the manufacture of nanoparticles used in colon-targeted drug delivery systems. These systems are a form of non-invasive oral therapy used in the treatment of various diseases. To achieve successful colonic delivery, the chemical, enzymatic and mucoadhesive barriers within the gastrointestinal (GI) tract must be analyzed. This will allow for the nanomaterials to cross these barriers and reach the colon. This review provides information on the development of nanoparticles made from various polysaccharides, which can overcome multiple barriers along the GI tract and affect encapsulation efficiency, drug protection, and release mechanisms upon arrival in the colon. Also, there is information disclosed about the size of the nanoparticles that are usually involved in the mechanisms of diffusion through the barriers in the GI tract, which may influence early drug degradation and release in the digestive tract.

scholarly journals Design of a novel curcumin-soybean phosphatidylcholine complex-based targeted drug delivery systems

Drug Delivery ◽  
2017 ◽  
Vol 24 (1) ◽  
pp. 707-719 ◽  
Author(s):  
Jiajiang Xie ◽  
Yanxiu Li ◽  
Liang Song ◽  
Zhou Pan ◽  
Shefang Ye ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Targeted Drug ◽  
Targeted Drug Delivery Systems
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