scholarly journals Sevoflurane provides better haemodynamic stability than propofol during right ventricular ischaemia–reperfusion

2019 ◽  
Vol 30 (1) ◽  
pp. 129-135
Author(s):  
Pernille Haraldsen ◽  
Doris Cunha-Goncalves ◽  
Carsten Metzsch ◽  
Lars Algotsson ◽  
Sandra Lindstedt ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Coronary Artery ◽  
Right Ventricular ◽  
Vascular Resistance ◽  
Right Coronary Artery ◽  
Stroke Work ◽  
Artery Blood Flow ◽  
Ischaemia Reperfusion ◽  
Haemodynamic Stability

Abstract OBJECTIVES To assess whether sevoflurane provides better haemodynamic stability than propofol in acute right ventricular (RV) ischaemia–reperfusion. METHODS Open-chest pigs (mean ± standard deviation, 68.8 ± 4.2 kg) anaesthetized with sevoflurane (n = 6) or propofol (n = 6) underwent 60 min of RV free wall ischaemia and 150 min of reperfusion. Haemodynamic parameters and blood flow in the 3 major coronary arteries were continuously monitored. Biomarkers of cardiac ischaemia were analysed. RESULTS Mean arterial pressure and stroke volume decreased, whereas pulmonary vascular resistance increased equally in both groups. Heart rate increased 7.5% with propofol (P < 0.05) and 17% with sevoflurane (P < 0.05). At reperfusion, left atrial pressure and systemic vascular resistance decreased with sevoflurane. While RV stroke work (mmHg·ml) and cardiac output (l·min−1) decreased in the propofol group (4.2 ± 1.2 to 2.9 ± 1.7 and 2.65 ± 0.44 to 2.28 ± 0.56, respectively, P < 0.05 both), they recovered to baseline levels in the sevoflurane group (4.1 ± 1.5 to 4.0 ± 1.5 and 2.77 ± 0.6 to 2.6 ± 0.5, respectively, P > 0.05). Circumflex and left anterior descending coronary artery blood flow decreased in both groups. Right coronary artery blood flow (ml·min−1) decreased with propofol (38 ± 9 to 28 ± 9, P < 0.05), but not with sevoflurane (28 ± 11 to 28 ± 17, P > 0.05). Biomarkers of cardiac ischaemia increased in both groups. CONCLUSIONS Compared to propofol, sevoflurane-anaesthetized pigs showed higher RV stroke work, cardiac output and right coronary artery blood flow during reperfusion. These findings warrant a clinical trial of sevoflurane in RV ischaemia in humans.

scholarly journals Phasic right coronary artery blood flow in conscious dogs with normal and elevated right ventricular pressures.

1976 ◽  
Vol 39 (6) ◽  
pp. 760-766 ◽  
Author(s):  
H S Lowensohn ◽  
E M Khouri ◽  
D E Gregg ◽  
R L Pyle ◽  
R E Patterson
Keyword(s):  
Blood Flow ◽  
Coronary Artery ◽  
Right Ventricular ◽  
Right Coronary Artery ◽  
Conscious Dogs ◽  
Artery Blood Flow

Effects of vasopressin on left anterior descending coronary artery blood flow during extremely low cardiac output

Resuscitation ◽  
2004 ◽  
Vol 62 (2) ◽  
pp. 229-235 ◽  
Author(s):  
Viktoria D Mayr ◽  
Volker Wenzel ◽  
Tilko Müller ◽  
Herwig Antretter ◽  
Klaus Rheinberger ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Coronary Artery ◽  
Artery Blood Flow ◽  
Low Cardiac Output

Effects of pulmonary balloon valvuloplasty on right coronary artery blood flow in pulmonary valve stenosis

1998 ◽  
Vol 82 (5) ◽  
pp. 692-696 ◽  
Author(s):  
Ioannis E. Kallikazaros ◽  
Costas G. Stratos ◽  
Costas P. Tsioufis ◽  
Christodoulos I. Stefanadis ◽  
Pavlos K. Toutouzas
Keyword(s):  
Blood Flow ◽  
Coronary Artery ◽  
Right Coronary Artery ◽  
Pulmonary Valve ◽  
Balloon Valvuloplasty ◽  
Artery Blood Flow ◽  
Pulmonary Valve Stenosis

Effects of exercise, hypoxia and feeding on the gastrointestinal blood flow in the Atlantic cod Gadus morhua

1991 ◽  
Vol 158 (1) ◽  
pp. 181-198 ◽  
Author(s):  
M. Axelsson ◽  
R. Fritsche
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Vascular Resistance ◽  
Mesenteric Artery ◽  
Gadus Morhua ◽  
Atlantic Cod ◽  
Control Mechanisms ◽  
Artery Blood Flow ◽  
Blood Flows ◽  
Mesenteric Artery Blood Flow

Cardiac output, ventral and dorsal aortic blood pressure, heart rate, and coeliac and mesenteric artery blood flow were recorded simultaneously in the Atlantic cod, Gadus morhua L., at rest, during exercise, during hypoxia and after feeding. In the resting unfed animals, coeliac artery blood flow was 4.1 +/− 0.8 ml min-1 kg-1 and mesenteric artery blood flow was 3.5 +/− 1.1 ml min-1 kg-1 (mean +/− S.E.M., N = 10); together, these flows represent approximately 40% of the cardiac output. Exercise or exposure to hypoxia resulted in increased visceral vascular resistance, leading to reductions in the coeliac and mesenteric artery blood flows. Coeliac and mesenteric blood flows were increased 24 h after feeding and the coeliac and systemic vascular resistances decreased in comparison with the prefeeding values. Phentolamine did not affect the gastrointestinal artery blood flow, but produced a significant decrease in the mesenteric and systemic vascular resistance. Treatment with bretylium and phentolamine revealed differences between the coeliac and the mesenteric vasculature regarding the control mechanisms during hypoxia and during exercise and feeding. During hypoxia, an adrenergic control of the gastrointestinal vasculature with both nervous and humoral components was found, whereas during exercise and after feeding an additional non-adrenergic mechanism controlling gut blood flow was demonstrated.

scholarly journals Elevated oxidative stress and endothelial dysfunction in right coronary artery of right ventricular hypertrophy

2011 ◽  
Vol 110 (6) ◽  
pp. 1674-1681 ◽  
Author(s):  
Xiao Lu ◽  
Charles Q. Dang ◽  
Xiaomei Guo ◽  
Sabee Molloi ◽  
Cynthia D. Wassall ◽  
...  
Keyword(s):  
Blood Flow ◽  
Shear Stress ◽  
Coronary Artery ◽  
Endothelial Dysfunction ◽  
Wall Shear Stress ◽  
Endothelial Function ◽  
Right Ventricular ◽  
Right Coronary Artery ◽  
Ventricular Hypertrophy ◽  
Basal Tone

Remodeling of right coronary artery (RCA) occurs during right ventricular hypertrophy (RVH) induced by banding of the pulmonary artery (PA). The effect of RVH on RCA endothelial function and reactive oxygen species (ROS) in vessel wall remains unclear. A swine RVH model ( n = 12 pigs) induced by PA banding was used to study RCA endothelial function and ROS level. To obtain longitudinal coronary hemodynamic and geometric data, digital subtraction angiography was used during the progression of RVH. Blood flow in the RCA increased by 82% and lumen diameter of RCA increased by 22% over a 4-wk period of RVH. The increase in blood flow and the commensurate increase in diameter resulted in a constant wall shear stress in RCA throughout the RVH period. ROS was elevated by ∼100% in RCA after 4 wk of PA banding. The expressions of p47phox, NADPH oxidase (NOX1, NOX2, and NOX4) were upregulated in the range of 20–300% in RCA of RVH. The endothelial function was compromised in RCA of RVH as attributed to insufficient endothelial nitric oxide synthase cofactor tetrahydrobiopterin. In vivo angiographic analysis suggests an increased basal tone in the RCA during RVH. In conclusion, stretch due to outward remodeling of RCA during RVH (at constant wall shear stress), similar to vessel stretch in hypertension, appears to induce ROS elevation, endothelial dysfunction, and an increase in basal tone.

scholarly journals Right coronary artery becomes stiffer with increase in elastin and collagen in right ventricular hypertrophy

2009 ◽  
Vol 106 (4) ◽  
pp. 1338-1346 ◽  
Author(s):  
Marisa Garcia ◽  
Ghassan S. Kassab
Keyword(s):  
Blood Flow ◽  
Coronary Artery ◽  
Right Ventricular ◽  
Right Coronary Artery ◽  
Vessel Wall ◽  
Ventricular Hypertrophy ◽  
Elastic Moduli ◽  
Multiphoton Microscopy ◽  
Right Ventricular Hypertrophy ◽  
Adventitial Layer

Changes in blood flow influence the structure, function, mechanical properties, and remodeling of arteries. The objective of the present study was to investigate the role of increased blood flow on the biaxial incremental elastic moduli of the porcine right coronary artery (RCA) and to determine the microstructural basis for the changes in moduli. We hypothesized that an increase in RCA flow will lead to increased stiffness in conjunction with remodeling of elastin and collagen in the vessel wall. The control and experimental groups consisted of five RCA vessels each. The RCA of the experimental group was exposed to 4 wk of flow-overload in right ventricular hypertrophy induced by pulmonary artery banding. Stress-strain relationships were determined and the incremental elastic moduli were derived in the circumferential, axial, and cross directions. The results show a significant increase in the elastic moduli in the circumferential (262.7 ± 15.7 vs. 120.2 ± 12.4 kPa; P < 0.001), axial (177.8 ± 25.5 vs. 100.3 ± 11.9 kPa; P = 0.025), and cross directions (104.8 ± 8.2 vs. 68.2 ± 8.6 kPa; P = 0.016) of the experimental RCA compared with controls. Multiphoton microscopy was used to assess the changes in elastin and collagen content in the media and adventitia of the vessel wall. We found a significant increase in elastin and collagen area fraction particularly in the adventitial layer. These data suggest stiffening of the vessel wall as a result of increased elastin and more predominantly collagen.

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