708Incidence of congenital anomalies in children born after assisted reproduction in the Czech Republic

Abstract Background The number of children conceived by assisted reproduction techniques (ART) is increasing in the Czech Republic. However, several studies reported increased incidence of congenital anomalies in ART conceived children. The main goal of this study was to evaluate this theoretical risk using population-based data from Czech medial registries. Methods The retrospective epidemiological analysis was performed using data from the National Registry of Congenital Anomalies and National Registry of Newborns, run by the Institute of Health Information and Statistics of the Czech Republic. All diagnoses of congenital anomalies (Q00-Q99) were included. We compared the incidences of congenital anomalies in naturally conceived children and ART conceived children born in the Czech Republic during 5 years period (2013-2017). Statistical analysis was performed by Fisher's exact test. Results During the selected period there were 547 675 children born in the Czech Republic (531 064 were naturally conceived children and 16 611 were ART conceived children). The incidence of congenital anomalies was 3.90% in naturally conceived children group and 4.35% in ART conceived children. This difference is statistically significant (p = 0.003). Conclusions In our population-based study, we confirmed a significantly higher general incidence of congenital anomalies in ART conceived children. Key messages The general incidence of congenital anomalies in ART conceived children is higher (compared to the incidence of congenital anomalies in naturally conceived children). Possible causes of this phenomenon shall be further analysed.

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747Incidence of anencephaly in the Czech Republic: Long-term population based study

International Journal of Epidemiology ◽

10.1093/ije/dyab168.618 ◽

2021 ◽

Vol 50 (Supplement_1) ◽

Author(s):

Antonin Sipek ◽

Vladimir Gregor ◽

Jan Klaschka ◽

Marek Maly ◽

Antonin Sipek

Keyword(s):

Czech Republic ◽

Population Based ◽

National Registry ◽

Ultrasound Screening ◽

Population Based Study ◽

The Czech Republic ◽

Exact Test ◽

Total Incidence ◽

The Central Nervous System

Abstract Background Anencephaly is a lethal anomaly of the central nervous system from the group of neural tube defects. The main goal of our study was to evaluate the incidence of anencephaly (and its possible trends) during the 53 years period. Methods For this study, we used data from the National Registry of Congenital Anomalies of the Czech Republic. We analysed the incidence of anencephaly in births and in prenatally diagnosed cases during the 1964-2016 period. We also evaluated maternal age in these cases. The statistical analysis was performed by Poisson regression and Fisher's exact test. Results During the study period there were 6 891 062 children born in the Czech Republic. Among those, 1232 children were born with anencephaly. Another 966 cases of anencephaly were diagnosed during prenatal diagnosis and these pregnancies were electively terminated, the total number of anencephaly cases was 2198. The total incidence of anencephaly significantly decreased during the study period (p = 0.0136). The incidence in births decreased significantly as well (p < 0.001). We found statistically higher incidence of anencephaly in elder mothers (42 years and over). Conclusions Gradual implementation of ultrasound prenatal diagnostics started in the 80s of the last century and lead to a very significant decrease in the incidence of anencephaly cases in births. Additionally, the total incidence of anencephaly decreased significantly as well. Key messages Incidence of anencephaly in births decreased rapidly with gradual implementation of population wide ultrasound screening.

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Neighbourhood socioeconomic indicators and depressive symptoms in the Czech Republic: a population based study

International Journal of Public Health ◽

10.1007/s00038-009-8029-1 ◽

2009 ◽

Vol 54 (4) ◽

pp. 283-293 ◽

Cited By ~ 11

Author(s):

Jitka Pikhartova ◽

Tarani Chandola ◽

Ruzena Kubinova ◽

Martin Bobak ◽

Amanda Nicholson ◽

...

Keyword(s):

Czech Republic ◽

Depressive Symptoms ◽

Population Based ◽

Socioeconomic Indicators ◽

Population Based Study ◽

The Czech Republic

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Incidence and prevalence of psoriatic arthritis, ankylosing spondylitis, and reactive arthritis in the first descriptive population-based study in the Czech Republic

Scandinavian Journal of Rheumatology ◽

10.3109/03009740903544212 ◽

2010 ◽

Vol 39 (4) ◽

pp. 310-317 ◽

Cited By ~ 40

Author(s):

P Hanova ◽

K Pavelka ◽

I Holcatova ◽

H Pikhart

Keyword(s):

Czech Republic ◽

Psoriatic Arthritis ◽

Ankylosing Spondylitis ◽

Reactive Arthritis ◽

Population Based ◽

Population Based Study ◽

The Czech Republic

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National Registry of Congenital Anomalies of the Czech Republic: Commemorating 50 Years of the Official Registration

Central European Journal of Public Health ◽

10.21101/cejph.a4201 ◽

2014 ◽

Vol 22 (4) ◽

pp. 287-290 ◽

Cited By ~ 2

Author(s):

Antonín Šípek ◽

Vladimír Gregor ◽

Jiří Horáček ◽

Antonín Šípek

Keyword(s):

Czech Republic ◽

Congenital Anomalies ◽

National Registry ◽

The Czech Republic

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Recent epidemiology of patients with Gastro-Entero-Pancreatic Neuroendocrine Neoplasms (GEP-NEN) in Japan: a population-based study

10.21203/rs.3.rs-18847/v2 ◽

2020 ◽

Author(s):

Toshihiko Masui ◽

Tetsuhide Ito ◽

Izumi Komoto ◽

Shinji Uemoto

Keyword(s):

Cancer Registry ◽

Population Data ◽

Population Based ◽

National Registry ◽

Neuroendocrine Neoplasms ◽

Population Based Study ◽

National Cancer Registry ◽

Exact Etiology ◽

Using Data ◽

Population Based Registry

Abstract Background: The worldwide prevalence and incidence of neuroendocrine neoplasms (NEN) have been increasing recently, although few studies have analyzed data on the current situation of NENs in Japan. Here, the Japan Neuroendocrine Tumor Society (JNETS) planned to investigate the recent incidence and distribution of these tumors using data from the national cancer registry started in 2016. This study examined the incidence and distribution of primary sites as well as disease progression from this population-based registry. Methods: A retrospective, population-based study using data from the national cancer registry in Japan (NCR) was conducted to evaluate patients with gastro-entero-pancreatic NEN (GEP-NEN) in 2016. Associated population data were used to determine annual age-adjusted incidences. Results: A total of 6735 individuals were diagnosed with GEP-NEN in Japan in 2016. Annual onset incidence was 0.70/100,000 for pancreatic NEN and 2.84/100,000 for gastrointestinal NEN. NEN in the ileum accounted for only 1% of total GEP-NENs in Japan. Most NENs in the esophagus or lungs were neuroendocrine carcinomas (NECs), while the majority of those in the duodenum, ileum, appendix and rectum were grade 1 neuroendocrine tumors (NETs). Median age at initial diagnosis was in between 60 to 65. Initial progression of the tumor was mostly limited to local for tumors in the duodenum, appendix and rectum, while those in the esophagus, stomach and colon tended to show distant metastasis. In Japan, initial treatment for GEP-NENs was resection even if the tumor was NEC.Conclusions: This is the first report of a national registry-based incidence and distribution of GEP-NEN in Japan. These data will serve as an important first step to determining the exact etiology and trends for this pathology in Japan.

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Recent epidemiology of patients with Gastro-Entero-Pancreatic Neuroendocrine Neoplasms (GEP-NEN) in Japan: a population-based study

10.21203/rs.3.rs-18847/v4 ◽

2020 ◽

Author(s):

Toshihiko Masui ◽

Tetsuhide Ito ◽

Izumi Komoto ◽

Shinji Uemoto ◽

project study group

Keyword(s):

Cancer Registry ◽

Population Data ◽

Population Based ◽

National Registry ◽

Neuroendocrine Neoplasms ◽

Population Based Study ◽

National Cancer Registry ◽

Exact Etiology ◽

Using Data ◽

Population Based Registry

Abstract Background: The worldwide prevalence and incidence of neuroendocrine neoplasms (NEN) have been increasing recently, although few studies have analyzed data on the current situation of NENs in Japan. Here, the Japan Neuroendocrine Tumor Society (JNETS) planned to investigate the recent incidence and distribution of these tumors using data from the national cancer registry started in 2016. This study examined the incidence and distribution of primary sites as well as rate of advanced disease from this population-based registry.Methods: A retrospective, population-based study using data from the national cancer registry in Japan (NCR) was conducted to evaluate patients with gastro-entero-pancreatic NEN (GEP-NEN) in 2016. Associated population data were used to determine annual age-adjusted incidences.Results: A total of 6735 individuals were diagnosed with GEP-NEN in Japan in 2016. Annual onset incidence was 0.70/100,000 for pancreatic NEN and 2.84/100,000 for gastrointestinal NEN. NEN in the ileum accounted for only 1% of total GEP-NENs in Japan. Most NENs in the esophagus or lungs were neuroendocrine carcinomas (NECs), while the majority of those in the duodenum, ileum, appendix and rectum were grade 1 neuroendocrine tumors (NETs). Median age at initial diagnosis was in between 60 to 65. Tumors in the duodenum, appendix and rectum were mostly limited to local, while those in the esophagus, stomach and colon tended to show distant metastasis. In Japan, initial treatment for GEP-NENs was resection even if the tumor was NEC.Conclusions: This is the first report of a national registry-based incidence and distribution of GEP-NEN in Japan. These data will serve as an important first step to determining the exact etiology and trends for this pathology in Japan.

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Recent epidemiology of patients with Gastro-Entero-Pancreatic Neuroendocrine Neoplasms (GEP-NEN) in Japan: a population-based study

10.21203/rs.3.rs-18847/v5 ◽

2020 ◽

Author(s):

Toshihiko Masui ◽

Tetsuhide Ito ◽

Izumi Komoto ◽

Shinji Uemoto ◽

project study group

Keyword(s):

Cancer Registry ◽

Population Data ◽

Population Based ◽

National Registry ◽

Neuroendocrine Neoplasms ◽

Population Based Study ◽

National Cancer Registry ◽

Exact Etiology ◽

Using Data ◽

Population Based Registry

Abstract Background: The worldwide prevalence and incidence of neuroendocrine neoplasms (NEN) have been increasing recently, although few studies have analyzed data on the current situation of NENs in Japan. Here, the Japan Neuroendocrine Tumor Society (JNETS) planned to investigate the recent incidence and distribution of these tumors using data from the national cancer registry started in 2016. This study examined the incidence and distribution of primary sites as well as rate of advanced disease from this population-based registry.Methods: A retrospective, population-based study using data from the national cancer registry in Japan (NCR) was conducted to evaluate patients with gastro-entero-pancreatic NEN (GEP-NEN) in 2016. Associated population data were used to determine annual age-adjusted incidences.Results: A total of 6735 individuals were diagnosed with GEP-NEN in Japan in 2016. Annual onset incidence was 0.70/100,000 for pancreatic NEN and 2.84/100,000 for gastrointestinal NEN. NEN in the ileum accounted for only 1% of total GEP-NENs in Japan. Most NENs in the esophagus or lungs were neuroendocrine carcinomas (NECs), while the majority of those in the duodenum, ileum, appendix and rectum were grade 1 neuroendocrine tumors (NETs). Median age at initial diagnosis was in between 60 to 65. Tumors in the duodenum, appendix and rectum were mostly limited to local, while those in the esophagus, stomach and colon tended to show distant metastasis. In Japan, initial treatment for GEP-NENs was resection even if the tumor was NEC.Conclusions: This is the first report of a national registry-based incidence and distribution of GEP-NEN in Japan. These data will serve as an important first step to determining the exact etiology and trends for this pathology in Japan.

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