National Registry of Congenital Anomalies of the Czech Republic: Commemorating 50 Years of the Official Registration

Abstract Background The number of children conceived by assisted reproduction techniques (ART) is increasing in the Czech Republic. However, several studies reported increased incidence of congenital anomalies in ART conceived children. The main goal of this study was to evaluate this theoretical risk using population-based data from Czech medial registries. Methods The retrospective epidemiological analysis was performed using data from the National Registry of Congenital Anomalies and National Registry of Newborns, run by the Institute of Health Information and Statistics of the Czech Republic. All diagnoses of congenital anomalies (Q00-Q99) were included. We compared the incidences of congenital anomalies in naturally conceived children and ART conceived children born in the Czech Republic during 5 years period (2013-2017). Statistical analysis was performed by Fisher's exact test. Results During the selected period there were 547 675 children born in the Czech Republic (531 064 were naturally conceived children and 16 611 were ART conceived children). The incidence of congenital anomalies was 3.90% in naturally conceived children group and 4.35% in ART conceived children. This difference is statistically significant (p = 0.003). Conclusions In our population-based study, we confirmed a significantly higher general incidence of congenital anomalies in ART conceived children. Key messages The general incidence of congenital anomalies in ART conceived children is higher (compared to the incidence of congenital anomalies in naturally conceived children). Possible causes of this phenomenon shall be further analysed.

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Incidence of Hospitalized Stroke in the Czech Republic: The National Registry of Hospitalized Patients

Journal of Stroke and Cerebrovascular Diseases ◽

10.1016/j.jstrokecerebrovasdis.2016.11.006 ◽

2017 ◽

Vol 26 (5) ◽

pp. 979-986 ◽

Cited By ~ 10

Author(s):

Petra Sedova ◽

Robert D. Brown ◽

Miroslav Zvolsky ◽

Pavla Kadlecova ◽

Tomas Bryndziar ◽

...

Keyword(s):

Czech Republic ◽

National Registry ◽

Hospitalized Patients ◽

The Czech Republic

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RG-001 Perinatal outcomes of children born as a result of IVF in the Czech Republic during 2000–2006: congenital anomalies and biosocial factors

Reproductive BioMedicine Online ◽

10.1016/s1472-6483(10)61576-3 ◽

2008 ◽

Vol 16 ◽

pp. S-44

Author(s):

A Sipek ◽

T Mardesic ◽

A Sipek ◽

V Gregor ◽

J Horacek ◽

...

Keyword(s):

Czech Republic ◽

Congenital Anomalies ◽

Perinatal Outcomes ◽

The Czech Republic

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Neonatal outcomes after fetal exposure to methadone and buprenorphine: national registry studies from the Czech Republic and Norway

Addiction ◽

10.1111/add.14192 ◽

2018 ◽

Vol 113 (7) ◽

pp. 1286-1294 ◽

Cited By ~ 14

Author(s):

Blanka Nechanská ◽

Viktor Mravčík ◽

Svetlana Skurtveit ◽

Ingunn Olea Lund ◽

Roman Gabrhelík ◽

...

Keyword(s):

Czech Republic ◽

National Registry ◽

Neonatal Outcomes ◽

Fetal Exposure ◽

The Czech Republic

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Socioeconomic characteristics of women with substance use disorder during pregnancy and neonatal outcomes in their newborns: A national registry study from the Czech Republic

Drug and Alcohol Dependence ◽

10.1016/j.drugalcdep.2020.107933 ◽

2020 ◽

Vol 209 ◽

pp. 107933

Author(s):

Viktor Mravčík ◽

Blanka Nechanská ◽

Roman Gabrhelík ◽

Marte Handal ◽

Milada Mahic ◽

...

Keyword(s):

Substance Use ◽

Czech Republic ◽

Substance Use Disorder ◽

National Registry ◽

Neonatal Outcomes ◽

Registry Study ◽

The Czech Republic ◽

Socioeconomic Characteristics

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Development of percutaneous coronary interventions in the Czech Republic in 2005-2018. Results of the National Registry of Cardiovascular Interventions

Intervenční a akutní kardiologie ◽

10.36290/kar.2020.015 ◽

2020 ◽

Vol 19 (1) ◽

pp. 25-29

Author(s):

Michael Želízko ◽

Světlana Drábková ◽

Ingrid Kováčová ◽

Martin Mates

Keyword(s):

Czech Republic ◽

National Registry ◽

Percutaneous Coronary Interventions ◽

The Czech Republic ◽

Coronary Interventions ◽

Percutaneous Coronary ◽

Cardiovascular Interventions

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747Incidence of anencephaly in the Czech Republic: Long-term population based study

International Journal of Epidemiology ◽

10.1093/ije/dyab168.618 ◽

2021 ◽

Vol 50 (Supplement_1) ◽

Author(s):

Antonin Sipek ◽

Vladimir Gregor ◽

Jan Klaschka ◽

Marek Maly ◽

Antonin Sipek

Keyword(s):

Czech Republic ◽

Population Based ◽

National Registry ◽

Ultrasound Screening ◽

Population Based Study ◽

The Czech Republic ◽

Exact Test ◽

Total Incidence ◽

The Central Nervous System

Abstract Background Anencephaly is a lethal anomaly of the central nervous system from the group of neural tube defects. The main goal of our study was to evaluate the incidence of anencephaly (and its possible trends) during the 53 years period. Methods For this study, we used data from the National Registry of Congenital Anomalies of the Czech Republic. We analysed the incidence of anencephaly in births and in prenatally diagnosed cases during the 1964-2016 period. We also evaluated maternal age in these cases. The statistical analysis was performed by Poisson regression and Fisher's exact test. Results During the study period there were 6 891 062 children born in the Czech Republic. Among those, 1232 children were born with anencephaly. Another 966 cases of anencephaly were diagnosed during prenatal diagnosis and these pregnancies were electively terminated, the total number of anencephaly cases was 2198. The total incidence of anencephaly significantly decreased during the study period (p = 0.0136). The incidence in births decreased significantly as well (p < 0.001). We found statistically higher incidence of anencephaly in elder mothers (42 years and over). Conclusions Gradual implementation of ultrasound prenatal diagnostics started in the 80s of the last century and lead to a very significant decrease in the incidence of anencephaly cases in births. Additionally, the total incidence of anencephaly decreased significantly as well. Key messages Incidence of anencephaly in births decreased rapidly with gradual implementation of population wide ultrasound screening.

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Comparison of Therapies in MS Patients After the First Demyelinating Event in Real Clinical Practice in the Czech Republic: Data From the National Registry ReMuS

Frontiers in Neurology ◽

10.3389/fneur.2020.593527 ◽

2021 ◽

Vol 11 ◽

Author(s):

Zbyšek Pavelek ◽

Lukáš Sobíšek ◽

Jana Šarláková ◽

Pavel Potužník ◽

Marek Peterka ◽

...

Keyword(s):

Czech Republic ◽

Clinical Practice ◽

National Registry ◽

Term Therapy ◽

The Czech Republic ◽

Significant Difference ◽

The Central Nervous System ◽

Edss Score ◽

Long Term Therapy ◽

Real Clinical Practice

Background: Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system. Well-established drugs used for MS patients after the first demyelinating event in the Czech Republic include glatiramer acetate (GA), interferon beta-1a (IFNβ-1a), IFN beta-1b (IFNβ-1b), peginterferon beta-1a (peg-IFNβ-1a), and teriflunomide.Objective: The objective of this observational study was to compare the effectiveness of the abovementioned drugs in patients with MS who initiated their therapy after the first demyelinating event. Patients were followed for up to 2 years in real clinical practice in the Czech Republic.Methods: A total of 1,654 MS patients treated after the first demyelinating event and followed up for 2 years were enrolled. Evaluation parameters (endpoints) included the annualized relapse rate (ARR), time to next relapse, change in the Expanded Disability Status Scale (EDSS) score, and time of confirmed disease progression (CDP). When patients ended the therapy before the observational period, the reason for ending the therapy among different treatments was compared.Results: No significant difference was found among the groups of patients treated with IFNβ-1a/1b, GA, or teriflunomide for the following parameters: time to the first relapse, change in the EDSS score, and the proportion of patients with CDP. Compared to IFNβ-1a (44 mcg), a significant increase in the percentage of relapse-free patients was found for GA, but this treatment effect was not confirmed by the validation analysis. Compared to the other drugs, there was a significant difference in the reasons for terminating GA therapy.Conclusion: Small differences were found among GA, IFNβ and teriflunomide therapies, with no significant impact on the final outcome after 2 years. Therefore, in clinical practice, we recommend choosing the drug based on individual potential risk from long-term therapy and on patient preferences and clinical characteristics.

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