scholarly journals PM347. Postnatal exposure to valproic acid in postnatal day 2–4 rats shows deficit of social interaction

2016 ◽  
Vol 19 (Suppl_1) ◽  
pp. 27-27
Keyword(s):  
Valproic Acid ◽  
Social Interaction ◽  
Postnatal Exposure

Oxytocin attenuates deficits in social interaction but not recognition memory in a prenatal valproic acid-induced mouse model of autism

2017 ◽  
Vol 96 ◽  
pp. 130-136 ◽  
Author(s):  
Yuta Hara ◽  
Yukio Ago ◽  
Momoko Higuchi ◽  
Shigeru Hasebe ◽  
Takanobu Nakazawa ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Social Interaction ◽  
Recognition Memory ◽  
Mouse Model

493. Improvement of Social Interaction and Cognition by Oxytocin for Autism-Like Behaviors in Valproic Acid-Exposed Rats

2017 ◽  
Vol 81 (10) ◽  
pp. S200-S201
Author(s):  
Kazuya Matsuo ◽  
Yasushi Yabuki ◽  
Kohji Fukunaga
Keyword(s):  
Valproic Acid ◽  
Social Interaction

mS-11, a mimetic of the mSin3-binding helix in NRSF, ameliorates social interaction deficits in a prenatal valproic acid-induced autism mouse model

2019 ◽  
Vol 176 ◽  
pp. 1-5 ◽  
Author(s):  
Haruki Kawase ◽  
Yukio Ago ◽  
Megumi Naito ◽  
Momoko Higuchi ◽  
Yuta Hara ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Social Interaction ◽  
Mouse Model

scholarly journals Effects of rapamycin treatment on impaired social interaction and gene expression in mice treated prenatally with valproic acid

IBRO Reports ◽  
2019 ◽  
Vol 6 ◽  
pp. S463
Author(s):  
Hiroko Kotajima ◽  
Toshiyuki Kobayashi ◽  
Hirofumi Kashii ◽  
Atsushi Sato ◽  
Yoko Hagino ◽  
...  
Keyword(s):  
Gene Expression ◽  
Valproic Acid ◽  
Social Interaction ◽  
Rapamycin Treatment

scholarly journals Altered behavioral development in Nrf2 knockout mice following early postnatal exposure to valproic acid

2014 ◽  
Vol 109 ◽  
pp. 132-142 ◽  
Author(s):  
Melody A. Furnari ◽  
Constance Lay-Lay Saw ◽  
Ah-Ng Kong ◽  
George C. Wagner
Keyword(s):  
Valproic Acid ◽  
Knockout Mice ◽  
Behavioral Development ◽  
Postnatal Exposure ◽  
Nrf2 Knockout

scholarly journals Effects of rapamycin on social interaction deficits and gene expression in mice exposed to valproic acid in utero

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Hiroko Kotajima-Murakami ◽  
Toshiyuki Kobayashi ◽  
Hirofumi Kashii ◽  
Atsushi Sato ◽  
Yoko Hagino ◽  
...  
Keyword(s):  
Gene Expression ◽  
Valproic Acid ◽  
Social Interaction ◽  
In Utero

scholarly journals Autism-like behaviours with transient histone hyperacetylation in mice treated prenatally with valproic acid

2013 ◽  
Vol 16 (1) ◽  
pp. 91-103 ◽  
Author(s):  
Shunsuke Kataoka ◽  
Kazuhiro Takuma ◽  
Yuta Hara ◽  
Yuko Maeda ◽  
Yukio Ago ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Social Interaction ◽  
Prenatal Exposure ◽  
Apoptotic Cell ◽  
Autism Spectrum ◽  
Prenatally Exposed ◽  
Histone Deacetylase Inhibition ◽  
Histone Hyperacetylation ◽  
The Social ◽  
Cortical Pathology

Abstract Maternal use of valproic acid (VPA) during pregnancy has been implicated in the aetiology of autism spectrum disorders in children, and rodents prenatally exposed to VPA showed behavioural alterations similar to those observed in humans with autism. However, the exact mechanism for VPA-induced behavioural alterations is not known. To study this point, we examined the effects of prenatal exposure to VPA and valpromide, a VPA analog lacking histone deacetylase inhibition activity, on behaviours, cortical pathology and histone acetylation levels in mice. Mice exposed to VPA at embryonic day 12.5 (E12.5), but not at E9 and E14.5, displayed social interaction deficits, anxiety-like behaviour and memory deficits at age 4–8 wk. In contrast to male mice, the social interaction deficits (a decrease in sniffing behaviour) were not observed in female mice at age 8 wk. The exposure to VPA at E12.5 decreased the number of Nissl-positive cells in the middle and lower layers of the prefrontal cortex and in the lower layers of the somatosensory cortex at age 8 wk. Furthermore, VPA exposure caused a transient increase in acetylated histone levels in the embryonic brain, followed by an increase in apoptotic cell death in the neocortex and a decrease in cell proliferation in the ganglionic eminence. In contrast, prenatal exposure to valpromide at E12.5 did not affect the behavioural, biochemical and histological parameters. Furthermore, these findings suggest that VPA-induced histone hyperacetylation plays a key role in cortical pathology and abnormal autism-like behaviours in mice.

scholarly journals Psilocybin rescues sociability deficits in an animal model of autism

2020 ◽  
Author(s):  
Irene Mollinedo-Gajate ◽  
Chenchen Song ◽  
Marcos Sintes-Rodriguez ◽  
Tobias Whelan ◽  
Anaïs Soula ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Valproic Acid ◽  
Animal Model ◽  
Social Interaction ◽  
Mouse Model ◽  
Therapeutic Agent ◽  
Autism Spectrum ◽  
The Core ◽  
Acute Response ◽  
The Social

AbstractAutism spectrum disorder (ASD) is characterized by core deficits in social interaction. The classic serotonergic psychedelic psilocybin has been suggested as a therapeutic agent that may ameliorate in the core symptomology of ASD. We found that the acute response to psilocybin was attenuated in the prenatal valproic acid exposure mouse model of ASD, and importantly, psilocybin rescued the social behavioural abnormalities present in these ASD model mice.

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