Single-Dose Hepatitis A Immunization: 7.5-Year Observational Pilot Study in Nicaraguan Children to Assess Protective Effectiveness and Humoral Immune Memory Response

ABSTRACTBoosting adult travelers with the virosome-formulated, aluminum-free hepatitis A vaccine Epaxal up to 128 months after a single primary dose confers full protection against hepatitis A, even in travelers aged 50 years and above. Delaying the booster dose did not influence the immune memory response to Epaxal.

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Insights into the naturally acquired immune response toPlasmodium vivaxmalaria

Parasitology ◽

10.1017/s0031182015000670 ◽

2016 ◽

Vol 143 (2) ◽

pp. 154-170 ◽

Cited By ~ 30

Author(s):

RHEA J. LONGLEY ◽

JETSUMON SATTABONGKOT ◽

IVO MUELLER

Keyword(s):

Immune Response ◽

Plasmodium Falciparum ◽

Humoral Immune Response ◽

Immune Dysfunction ◽

Epidemiological Studies ◽

Immune Memory ◽

Acquired Immunity ◽

Memory Response ◽

Humoral Immune

SUMMARYPlasmodium vivaxis the most geographically widespread of the malaria parasites causing human disease, yet it is comparatively understudied compared withPlasmodium falciparum.In this article we review what is known about naturally acquired immunity toP. vivax, and importantly, how this differs to that acquired againstP. falciparum.Immunity to clinicalP. vivaxinfection is acquired more quickly than toP. falciparum, and evidence suggests humans in endemic areas also have a greater capacity to mount a successful immunological memory response to this pathogen. Both of these factors give promise to the idea of a successfulP. vivaxvaccine. We review what is known about both the cellular and humoral immune response, including the role of cytokines, antibodies, immunoregulation, immune memory and immune dysfunction. Furthermore, we discuss where the future lies in terms of advancing our understanding of naturally acquired immunity toP. vivax, through the use of well-designed longitudinal epidemiological studies and modern tools available to immunologists.

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Immune memory at 17-years of follow-up of a single dose of live attenuated hepatitis A vaccine

Vaccine ◽

10.1016/j.vaccine.2017.11.036 ◽

2018 ◽

Vol 36 (1) ◽

pp. 114-121 ◽

Cited By ~ 13

Author(s):

Ying Chen ◽

Chen-Liang Zhou ◽

Xin-Jiang Zhang ◽

Zhi-Yong Hao ◽

Yan-Hong Zhang ◽

...

Keyword(s):

Single Dose ◽

Hepatitis A ◽

Immune Memory

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SARS-CoV-2-specific Humoral Immune Responses after A Single Dose of Inactivated Whole-virus SARS-CoV-2 Vaccine in Kidney Transplant Recipients: An Initial Report

10.1101/2021.07.19.21260694 ◽

2021 ◽

Author(s):

Jackrapong Bruminhent ◽

Sarinya Boongird ◽

Montira Assanatham ◽

Sasisopin Kiertiburanakul ◽

Kumthorn Malathum ◽

...

Keyword(s):

Single Dose ◽

Pilot Study ◽

Immune Responses ◽

Kidney Transplant ◽

Transplant Recipients ◽

Kidney Transplant Recipients ◽

Igg Antibody ◽

Initial Report ◽

Humoral Immune ◽

Humoral Immune Responses

We presented an initial pilot study report focused on immunogenicity and safety following an inactivated whole virus severe acute respiratory syndrome coronavirus 2 vaccination among kidney transplant (KT) recipients. At four weeks after the first dose of vaccine, the level of anti RBD IgG antibody was not significantly different compared to before vaccination in 30 KT recipients (p = 0.45). Moreover, a significant lower mean (95% CI) anti RBD IgG antibody was observed compared to 30 immunocompetent controls (2.4 [95% CI 1.3 to 3.5] vs. 173.1 [95% CI 88.3-2,457.9] AU/mL, p < 0.001). Mild adverse events included fever (17%) and localized pain at the injection site (14%) were observed after vaccination.

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