scholarly journals Fibronectin-binding protein I of Streptococcus pyogenes promotes T cell- independent proliferation of murine B lymphocytes and enhances the expression of MHC class II molecules on antigen-presenting cells [In Process Citation]

1998 ◽  
Vol 10 (11) ◽  
pp. 1657-1664 ◽  
Author(s):  
E Medina
Keyword(s):  
T Cell ◽  
B Lymphocytes ◽  
Mhc Class Ii ◽  
Streptococcus Pyogenes ◽  
Antigen Presenting Cells ◽  
Class Ii ◽  
Fibronectin Binding Protein ◽  
Fibronectin Binding ◽  
Antigen Presenting ◽  
Mhc Class Ii Molecules

Endocytosis and Biosynthetic Transport of Murine MHC Class II Molecules in Antigen Presenting Cells

Endocytosis ◽  
1992 ◽  
pp. 341-342
Author(s):  
J. Davoust ◽  
P. Cosson ◽  
J. M. Escola ◽  
J. Henry ◽  
M. Humbert ◽  
...  
Keyword(s):  
Mhc Class Ii ◽  
Antigen Presenting Cells ◽  
Class Ii ◽  
Antigen Presenting ◽  
Mhc Class Ii Molecules

scholarly journals Quantitative Analysis of the Efficiency of Clonal Deletion in the Thymus

1994 ◽  
Vol 4 (1) ◽  
pp. 43-53 ◽  
Author(s):  
Lisa M. Spain ◽  
Leslie J. Berg
Keyword(s):  
Epithelial Cells ◽  
Mhc Class Ii ◽  
Negative Selection ◽  
Gene Dosage ◽  
Antigen Presenting Cells ◽  
Class Ii ◽  
Clonal Deletion ◽  
Self Tolerance ◽  
Antigen Presenting ◽  
Mhc Class Ii Molecules

One of the major mechanisms for establishing self-tolerance is the clonal deletion of self-reactive T cells during their development in the thymus. Using a TCR transgenic mouse model, we have established a quantitativeex vivoassay for examining the sensitivity and specificity of negative selection. Thymic organ cultures established from mice of varying MHC haplotypes were incubated with antigen, and the efficiency of clonal deletion assessed. We show here that clonal deletion of CD4+8+thymocytes is sensitive to both the gene dosage and the allelic variation of MHC class II molecules expressed on thymic antigen-presenting cells. We also find that when epithelial cells in the thymic cortex are the only antigen-presenting cells expressing the appropriate MHC class II molecules, negative selection of CD4+8+cells is as efficient as when antigen is presented on all thymic antigen-presenting cells. These studies demonstrate that the induction of self-tolerance via clonal deletion in the thymus is a function not only of antigen concentration, but also of MHC class II cell-surface density. In addition, together with the reports of others, these results confirm that cortical epithelial cells can mediate negative selection, and demonstrate that they do so in the intact thymic microenvironment.

scholarly journals Host MHC class II+ antigen-presenting cells and CD4 cells are required for CD8-mediated graft-versus-leukemia responses following delayed donor leukocyte infusions

Blood ◽  
2006 ◽  
Vol 108 (6) ◽  
pp. 2106-2113 ◽  
Author(s):  
Ronjon Chakraverty ◽  
Hyeon-Seok Eom ◽  
Jessica Sachs ◽  
Jennifer Buchli ◽  
Pete Cotter ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Mhc Class Ii ◽  
Antigen Presenting Cells ◽  
Class Ii ◽  
Cd4 T Cell ◽  
Graft Versus Host ◽  
Graft Versus Leukemia ◽  
T Cell Help ◽  
Antigen Presenting

Abstract Following bone marrow transplantation, delayed donor leukocyte infusions (DLIs) can induce graft-versus-leukemia (GVL) effects without graft-versus-host disease (GVHD). These antitumor responses are maximized by the presence of host hematopoietic antigen-presenting cells (APCs) at the time of DLI. Using a tumor-protection model, we demonstrate here that GVL activity following administration of DLIs to established mixed chimeras is dependent primarily on reactivity to allogeneic MHC antigens rather than minor histocompatibility or tumor-associated antigens. CD8+ T-cell–dependent GVL responses against an MHC class II–negative tumor following delayed DLI require CD4+ T-cell help and are reduced significantly when host APCs lack MHC class II expression. CD4+ T cells primed by host APCs were required for maximal expansion of graft-versus-host reactive CD8+ T cells but not their synthesis of IFN-γ. In contrast, the GVL requirement for CD4+ T-cell help was bypassed almost completely when DLI was administered to freshly irradiated recipients, indicating that the host environment is a major factor influencing the cellular mechanisms of GVL.

scholarly journals Mouse γδ T cells are capable of expressing MHC class II molecules, and of functioning as antigen-presenting cells

2008 ◽  
Vol 203 (1) ◽  
pp. 3-11 ◽  
Author(s):  
Lan Cheng ◽  
Yan Cui ◽  
Hui Shao ◽  
Gencheng Han ◽  
Ling Zhu ◽  
...  
Keyword(s):  
T Cells ◽  
Mhc Class Ii ◽  
Γδ T Cells ◽  
Antigen Presenting Cells ◽  
Class Ii ◽  
Antigen Presenting ◽  
Mhc Class Ii Molecules

scholarly journals Direct binding of a myasthenia gravis related epitope to MHC class II molecules on living murine antigen-presenting cells.

1989 ◽  
Vol 8 (13) ◽  
pp. 4049-4052 ◽  
Author(s):  
E. Mozes ◽  
M. Dayan ◽  
E. Zisman ◽  
S. Brocke ◽  
A. Licht ◽  
...  
Keyword(s):  
Myasthenia Gravis ◽  
Mhc Class Ii ◽  
Antigen Presenting Cells ◽  
Class Ii ◽  
Direct Binding ◽  
Antigen Presenting ◽  
Mhc Class Ii Molecules
Sign in / Sign up

Export Citation Format

Share Document