scholarly journals Application of an in vitro drug screening assay based on the release of phosphoglucose isomerase to determine the structure-activity relationship of thiazolides against Echinococcus multilocularis metacestodes

2010 ◽  
Vol 65 (3) ◽  
pp. 512-519 ◽  
Author(s):  
B. Stadelmann ◽  
S. Scholl ◽  
J. Muller ◽  
A. Hemphill
Keyword(s):  
Drug Screening ◽  
Echinococcus Multilocularis ◽  
Phosphoglucose Isomerase ◽  
Activity Relationship ◽  
Screening Assay ◽  
Structure Activity ◽  
In Vitro Drug Screening ◽  
Drug Screening Assay ◽  
Relationship Of

scholarly journals Development of a preliminary in vitro drug screening assay based on a newly established culturing system for pre-adult fifth-stage Onchocerca volvulus worms

2019 ◽  
Vol 13 (1) ◽  
pp. e0007108 ◽  
Author(s):  
Denis Voronin ◽  
Nancy Tricoche ◽  
Shabnam Jawahar ◽  
Michael Shlossman ◽  
Christina A. Bulman ◽  
...  
Keyword(s):  
Drug Screening ◽  
Onchocerca Volvulus ◽  
Screening Assay ◽  
In Vitro Drug Screening ◽  
Drug Screening Assay

scholarly journals Microengineered peripheral nerve-on-a-chip for preclinical physiological testing

Lab on a Chip ◽  
2015 ◽  
Vol 15 (10) ◽  
pp. 2221-2232 ◽  
Author(s):  
Renee M. Huval ◽  
Oliver H. Miller ◽  
J. Lowry Curley ◽  
Yuwei Fan ◽  
Benjamin J. Hall ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Drug Screening ◽  
Late Stage ◽  
Nerve Tissue ◽  
Physiological Measures ◽  
Screening Assay ◽  
Lead Compounds ◽  
Drug Screening Assay

A microscale, organotypicin vitromodel of sensory peripheral nerve tissue may be assessed with clinically-relevant morphological and physiological measures for use as a drug screening assay for selecting promising lead compounds with higher chances of late-stage success.

scholarly journals From in vitro to in cellulo: structure–activity relationship of (2-nitrophenyl)methanol derivatives as inhibitors of PqsD in Pseudomonas aeruginosa

2014 ◽  
Vol 12 (32) ◽  
pp. 6094-6104 ◽  
Author(s):  
Michael P. Storz ◽  
Giuseppe Allegretta ◽  
Benjamin Kirsch ◽  
Martin Empting ◽  
Rolf W. Hartmann
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Relationship Of ◽  
Derivatives Of

More than 60 derivatives of (2-nitrophenyl)methanol were synthesized and evaluated regarding their potency to inhibit PqsD. In vitro and in cellulo structure–activity relationships were derived.

Discovery and Structure−Activity Relationship of Antagonists of B-Cell Lymphoma 2 Family Proteins with Chemopotentiation Activity in Vitro and in Vivo

2006 ◽  
Vol 49 (3) ◽  
pp. 1165-1181 ◽  
Author(s):  
Michael D. Wendt ◽  
Wang Shen ◽  
Aaron Kunzer ◽  
William J. McClellan ◽  
Milan Bruncko ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of
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