Spectrophotometric Determination of Oxazepam and Dipyridamole in Two-Component Mixtures

1982 ◽  
Vol 65 (1) ◽  
pp. 144-147
Author(s):  
Mohamed A Korany ◽  
Rolf Haller
Keyword(s):  
Simultaneous Determination ◽  
Spectrophotometric Determination ◽  
Coefficient Of Variation ◽  
Component Analysis ◽  
Simultaneous Equations ◽  
Two Component

Abstract The λpj method is applied to simultaneous determination of oxazepam and dipyridamole in 2-component mixtures. Authentic mixtures and tablets containing oxazepam and dipyridamole were assayed by measuring the absorbances in 0.1N H2SO4 and 0.05M borax solutions and calculating the λp2 at 2 wavelength sets: 272-312 nm (at 8 nm intervals) and 288-328' nm (at 8 nm intervals). The concentration is evaluated by solving a pair of simultaneous equations. The results obtained are reasonably reproducible with a coefficient of variation less than 2%. The proposed method is compared with the λA modification of Vierordt's method of 2-component analysis. The λpj method gave more accurate and precise results.

U.V. and U.V. Derivative Spectrophotometric Determination of Two- Component Mixtures

1991 ◽  
Vol 24 (3) ◽  
pp. 451-470 ◽  
Author(s):  
Hesham Salem ◽  
Magda El-Maamli ◽  
Mohamed El-Sadek ◽  
Afaf Aboul Kheir
Keyword(s):  
Spectrophotometric Determination ◽  
Two Component

Spectrophotometric Determination of Thiabendazole in Feeds

1965 ◽  
Vol 48 (2) ◽  
pp. 288-295
Author(s):  
C R Szalkowski ◽  
J Kanora
Keyword(s):  
Hydrogen Sulfide ◽  
Spectrophotometric Determination ◽  
Coefficient Of Variation ◽  
Zinc Dust ◽  
Improved Method ◽  
Subsequent Oxidation ◽  
Color Development ◽  
Thiazine Dye

Abstract An improved method has been developed for thiabendazole in feeds. Thiabendazole is extracted from the feed with 0.2N HCl in 50% methanol; interfering substances are removed by making the extract alkaline and extracting into chloroform. The thiabendazole is re-extracted with dilute HCl; the solution is reduced with zinc dust in the presence of p-phenylenediamine to form a hydrogen sulfide complex. After subsequent oxidation with ferric solution to form a thiazine dye, the dye is extracted into n-butanol and measured at 605 mμ. More than 30 commercial unmedicated cattle and swine feeds show an apparent thiabendazole content of 0.00006–0.00044%. Recoveries on feeds made to contain 0.0025–10.0% thiabendazole ranged from 97.6 to 106.6%, with a coefficient of variation of 2.44%. In studies of 30 other drugs added to feeds, only nithiazide, Enheptin, and sulfathiazole interfere. Many variables involved in the color development were studied. The method gives the most accurate and reproducible results on solutions containing 0.2–2.0 μg thiabendazole/ml.

Spectrophotometric Determination of Aminacrine Hydrochloride in Creams, Jellies, and Suppositories: Interlaboratory Study

1987 ◽  
Vol 70 (3) ◽  
pp. 560-565
Author(s):  
Elaine A Bunch
Keyword(s):  
Thin Layer ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Coefficient Of Variation ◽  
Visible Spectrum ◽  
Interlaboratory Study ◽  
Commercial Products ◽  
Absorbance Maximum

Abstract A previously reported visible spectrophotometric method for the analysis of aminacrine hydrochloride in creams, jellies, and suppositories was studied collaboratively by 8 laboratories. Aminacrine hydrochloride was extracted into acidic ethanol and its visible spectrum recorded. The amount present was calculated by determining the net absorbance between the absorbance maximum at about 402 nm and one-half the sum of the absorbance of the minima at about 389 and 412 nm. Each collaborator received 4 creams (0.2%), 1 jel (0.2%), 1 molded suppository (6 mg/3.198 g), and 2 gelatin-encapsulated suppository samples (12 mg/6.661 g and 14 mg/6.863 g). The cream samples included blind duplicates prepared to contain 0.212% aminacrine hydrochloride, 15% sulfanilamide, and 2% allantoin. Mean recovery for the authentic cream was 104.7% with a coefficient of variation (CV) of 9.22%. The commercial products contained these respective amounts (CVs): creams, 100.0% (2.48%) and 101.5% (2.16%); jel, 118.0% (9.58%); molded suppository, 102.7% (1.88%); and gelatin encapsulated suppositories, 93.1% (1.0%) and 94.3% (1.60%). Standard aminacrine hydrochloride provided for the study was 99.6% pure by nonaqueous titration. Thin layer chromatographic identification of aminacrine hydrochloride was also tested collaboratively. The method was not adopted by AOAC.

Spectrophotometric Determination of Atropine Sulfate in the Presence of Phenylmercury (II) Acetate

1981 ◽  
Vol 64 (4) ◽  
pp. 855-859
Author(s):  
Abdel Aziz M Wahbi ◽  
Magda Barary
Keyword(s):  
Least Squares ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Atropine Sulfate ◽  
Official Method ◽  
Method Of Least Squares ◽  
Orthogonal Function ◽  
Two Component ◽  
Good Agreement

Abstract Two-component spectrophotometric method of analysis using 2 wavelengths, the method of least squares using absorbances, the method using 2-orthogonal function coefficients, and the method of least squares using orthogonal function coefficients have been applied to the determination of atropine sulfate in the presence of phenylmercury (II) acetate, compounds whose spectra overlap. The first method gave erroneous results; the second method gave satisfactory results for synthetic mixtures. The fourth method was superior, especially in the presence of irrelevant absorption. It has been successfully used for determining atropine sulfate in injection solutions in which a cubic irrelevant absorption was present. Results were in good agreement with those obtained by the official method.

Application of a vidicon spectrometer for simultaneous multicomponent drug determinations.

1976 ◽  
Vol 22 (11) ◽  
pp. 1862-1867 ◽  
Author(s):  
A E McDowell ◽  
R S Harner ◽  
H L Pardue
Keyword(s):  
Simultaneous Determination ◽  
Small Computer ◽  
Ultraviolet Region ◽  
Matrix Equations ◽  
Aqueous Mixtures ◽  
Two Component ◽  
On Line ◽  
Absorbance Data ◽  
Rapid Scanning

Abstract A rapid scanning vidicon spectrometer has been evaluated for the simultaneous determination of drugs in mixtures, without a separation step. Spectral data in the ultraviolet region are collected on-line with a small computer at repetition rates of 100 scans per second. Absorbance data at several wavelengths are processed by matrix equations to resolve them into the concentration of each component in each mixture. Results are reported for two-component mixtures of procainamide and N-acetylprocainamide in serum, for two-component aqueous mixtures of butabarbital and seconbarbital, and for seven-component aqueous mixtures of phenobarbital, diphenylhydantoin, aminophylline, acetaminophen, salicylamide, phenylbutazone, and secobarbital. We conclude that the computer-inter-faced vidicon spectrometer is a viable tool for simultaneous multicomponent determinations.

Simultaneous Spectrophotometric Determination of Nifuroxime and Furazolidone in Pharmaceutical Preparations

1980 ◽  
Vol 63 (5) ◽  
pp. 992-995
Author(s):  
Laila Elsayed ◽  
Sayed M Hassan ◽  
Khadiga M Kelani ◽  
Hamed M El-Fatatry
Keyword(s):  
Simultaneous Determination ◽  
Spectrophotometric Determination ◽  
Pharmaceutical Preparations ◽  
Spectrophotometric Methods ◽  
First Derivative ◽  
Separation Step ◽  
Preliminary Separation

Abstract Two spectrophotometric methods have been developed for the simultaneous determination of nifuroxime and furazolidone in their pharmaceutical preparations. No preliminary separation step is required in either method. The first, a modified Vierordt method, gives accurate and reproducible results for both drugs. Mean percent recoveries for nifuroxime and furazolidone were 99.50 ±1.59 and 100.20 ±1.16 (P = 0.05), respectively. This method also gives accurate and reproducible results for the determination of nifuroxime and furazolidone in their pharmaceutical preparations: Tricofuran vaginal suppositories and powder. The second method, which involves the use of the first-derivative curves, gives unreliable results; the reasons for these are discussed.

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