Simultaneous Spectrophotometric Determination of Nifuroxime and Furazolidone in Pharmaceutical Preparations

1980 ◽  
Vol 63 (5) ◽  
pp. 992-995
Author(s):  
Laila Elsayed ◽  
Sayed M Hassan ◽  
Khadiga M Kelani ◽  
Hamed M El-Fatatry
Keyword(s):  
Simultaneous Determination ◽  
Spectrophotometric Determination ◽  
Pharmaceutical Preparations ◽  
Spectrophotometric Methods ◽  
First Derivative ◽  
Separation Step ◽  
Preliminary Separation

Abstract Two spectrophotometric methods have been developed for the simultaneous determination of nifuroxime and furazolidone in their pharmaceutical preparations. No preliminary separation step is required in either method. The first, a modified Vierordt method, gives accurate and reproducible results for both drugs. Mean percent recoveries for nifuroxime and furazolidone were 99.50 ±1.59 and 100.20 ±1.16 (P = 0.05), respectively. This method also gives accurate and reproducible results for the determination of nifuroxime and furazolidone in their pharmaceutical preparations: Tricofuran vaginal suppositories and powder. The second method, which involves the use of the first-derivative curves, gives unreliable results; the reasons for these are discussed.

scholarly journals Three Different Spectrophotometric Methods for Simultaneous Determination of Pyriproxyfen and Chlorothalonil Residues in Cucumber and Cabbage Samples

2019 ◽  
Vol 2019 ◽  
pp. 1-11
Author(s):  
Shilan A. Omer ◽  
Nabil A. Fakhre
Keyword(s):  
Simultaneous Determination ◽  
Simultaneous Estimation ◽  
Zero Crossing ◽  
Spectrophotometric Methods ◽  
First Derivative ◽  
The Third ◽  
Mean Centering ◽  
Relative Standard ◽  
One Way Anova

In this study, three simple and accurate spectrophotometric methods for simultaneous determination of pyriproxyfen and chlorothalonil residues in cucumbers and cabbages grown in experimental greenhouse were studied. The first method was based on the zero-crossing technique measurement for first and second derivative spectrophotometry. The second method was based on the first derivative of the ratio spectra. However, the third method was based on mean centering of ratio spectra. These procedures lack any previous separation steps. The calibration curves for three spectrophotometric methods are linear in the concentration range of 1–30 μg·mL−1 and 0.5–7 μg·mL−1 for pyriproxyfen and chlorothalonil successively. The recoveries ranged from 82.12–97.40% for pyriproxyfen and 81.51–97.04% for chlorothalonil with relative standard deviations less than 4.95% and 5.45% in all instances for pyriproxyfen and chlorothalonil, respectively. The results obtained from the proposed methods were compared statistically by using one-way ANOVA, and the results revealed there were no significant differences between ratio spectra and mean centering methods with the zero-crossing technique. The proposed methods are successfully applied for the simultaneous estimation of the residue of both pesticides in cucumber and cabbage samples.

scholarly journals Development of Ecofriendly Derivative Spectrophotometric Methods for the Simultaneous Quantitative Analysis of Remogliflozin and Vildagliptin from Formulation

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6160
Author(s):  
Mahesh Attimarad ◽  
Katharigatta N. Venugopala ◽  
Bandar E. Al-Dhubiab ◽  
Rafea Elamin Elgack Elgorashe ◽  
Sheeba Shafi
Keyword(s):  
Pharmaceutical Preparations ◽  
Peak Height ◽  
Zero Crossing ◽  
Spectrophotometric Methods ◽  
First Derivative ◽  
Relative Standard ◽  
Quality Control Study ◽  
Pharmaceutical Industries ◽  
Control Study

Three rapid, accurate, and ecofriendly processed spectrophotometric methods were validated for the concurrent quantification of remogliflozin (RGE) and vildagliptin (VGN) from formulations using water as dilution solvent. The three methods developed were based on the calculation of the peak height of the first derivative absorption spectra at zero-crossing points, the peak amplitude difference at selected wavelengths of the peak and valley of the ratio spectra, and the peak height of the ratio first derivative spectra. All three methods were validated adapting the ICH regulations. Both the analytes showed a worthy linearity in the concentration of 1 to 60 µg/mL and 2 to 90 µg/mL for VGN and RGE, respectively, with an exceptional regression coefficient (r2 ≥ 0.999). The developed methods demonstrated an excellent recovery (98.00% to 102%), a lower percent relative standard deviation, and a relative error (less than ±2%), confirming the specificity, precision, and accuracy of the proposed methods. In addition, validated spectrophotometric methods were commendably employed for the simultaneous determination of VGN and RGE from solutions prepared in the laboratory and the formulation. Hence, these methods can be utilized for the routine quality control study of the pharmaceutical preparations of VGN and RGE in pharmaceutical industries and laboratories. The ecofriendly nature of the anticipated spectrophotometric procedures was confirmed by the evaluation of the greenness profile by a semi-quantitative method and the quantitative and qualitative green analytical procedure index (GAPI) method.

First Derivative Spectrophotometric Determination of Anhydrotetracyclines in Tetracyclines

1988 ◽  
Vol 71 (4) ◽  
pp. 768-772 ◽  
Author(s):  
Abdel-Aziz M Wahbi ◽  
Hamad A Al-Khamees ◽  
Ahmad M A Yousef
Keyword(s):  
Rapid Method ◽  
Spectrophotometric Determination ◽  
Absorption Curve ◽  
British Pharmacopoeia ◽  
Spectrophotometric Methods ◽  
First Derivative ◽  
Tetracycline Hcl

Abstract A rapid method is presented for detection and determination of anhydrotetracycline- HCl (ATC-HC1) and 4-epianhydrotetracycline-HCl (4-EATC-HCl) in tetracycline-HCl (TC-HCl). The method determines the 2 compounds as a sum, not individually. The first derivative absorption curve has a trough (D1) at 460 nm which is linearly related to concentration (1-10 mg/mL). ATC-HC1 + 4-EATC-HCl content was determined in TC-HCl powder and capsules by the D1 and the compensation D1 spectrophotometric methods. The results were compared with those obtained using U.S. Pharmacopeia and British Pharmacopoeia methods

scholarly journals Spectrophotometric Determination of Antidepressant Drug Duloxetine in Pharmaceutical Preparations using π-Acceptors

2012 ◽  
Vol 9 (1) ◽  
pp. 323-329 ◽  
Author(s):  
Sidika Ertürk Toker ◽  
Armagan Önal
Keyword(s):  
Spectrophotometric Determination ◽  
Electron Donor ◽  
Pharmaceutical Analysis ◽  
Antidepressant Drug ◽  
Pharmaceutical Preparations ◽  
Reaction Conditions ◽  
Colored Complex ◽  
Complex Species ◽  
Spectrophotometric Methods

In this study, two simple and accurate spectrophotometric methods were presented for the determination of duloxetine hydrochloride (DLX) in pharmaceutical preparations. The methods were based on the reaction of DLX asn-electron donor with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and 7,7,8,8-tetracyanoquinodimethane (TCNQ) as π-acceptors to give highly colored complex species. The colored products were quantitated spectro-photometrically at 477 and 841 for DDQ, TCNQ, respectively. All variables were studied in order to optimize the reaction conditions. Beer's law was obeyed in the concentration ranges 10.0-50.0 and 15-60 μg mL−1for DDQ and TCNQ method, respectively. The proposed methods have been successfully applied to the pharmaceutical analysis without any interference from excipients. The suggested procedures could be used for the determination of DLX in pharmaceutical preparations being sensitive, simple and selective.

scholarly journals New Spectrophotometric Determination of Tinofovir in Bulk and Pharmaceutical Dosage Form

2009 ◽  
Vol 6 (2) ◽  
pp. 537-540 ◽  
Author(s):  
Manish Majumder ◽  
B. Gopinath ◽  
Girish Koni ◽  
Sanjeev Kumar Singh
Keyword(s):  
Acid Hydrolysis ◽  
Spectrophotometric Determination ◽  
Dosage Form ◽  
Estimation Method ◽  
Pharmaceutical Preparations ◽  
Pharmaceutical Formulations ◽  
Alkaline Condition ◽  
Pharmaceutical Dosage Form ◽  
Spectrophotometric Methods

Two new, selective and sensitive visible spectrophotometric methods (method A and B) have been developed for the estimation of tinofovir in bulk and in pharmaceutical preparations. Tinofovir was subjected to acid hydrolysis and this acid hydrolyzed drug was used for the estimation. Method A is based on the reaction with 3-methyl-2-benzothiazolinone hydrazone in the presence of ferric chloride, to form a colored species with a λmaxat 628.5 nm. Method B is based on the reaction with Folin-ciocalteu phenol’s reagent under alkaline condition with a λmaxat 768 nm. Beer’s law is obeyed in the concentration range of 5-40 µg/mL for method A and 2-30 µg/mL for method B, respectively. The methods were extended to pharmaceutical formulations and there was no interference from any common pharmaceutical excepients and diluents. The result of analysis has been validated statistically and by recovery studies.

FIRST-DERIVATIVE SPECTROPHOTOMETRIC DETERMINATION OF PYRIDOXINE HYDROCHLORIDE IN PHARMACEUTICAL PREPARATIONS

2001 ◽  
Vol 34 (11) ◽  
pp. 1875-1888 ◽  
Author(s):  
Vladi Olga Consigliere ◽  
Nelson Rafael Matta Vals ◽  
João Fernandes Magalhãs
Keyword(s):  
Spectrophotometric Determination ◽  
Pharmaceutical Preparations ◽  
Pyridoxine Hydrochloride ◽  
First Derivative

scholarly journals USE OF ION ASSOCIATION COMPLEX FORMATION FOR THE SPECTROPHOTOMETRIC DETERMINATION OF ITOPRIDE HCL IN BULK AND ITS PHARMACEUTICAL PREPARATIONS

2016 ◽  
Vol 9 (1) ◽  
pp. 81
Author(s):  
P. V. Lakshmana Rao ◽  
C. Rambabu
Keyword(s):  
Complex Formation ◽  
Spectrophotometric Determination ◽  
Pharmaceutical Preparations ◽  
Ion Association ◽  
Pharmaceutical Formulations ◽  
Spectrophotometric Methods ◽  
Itopride Hydrochloride ◽  
Soluble Ion ◽  
Association Complex

Objective: The authors report two simple, accurate and economic spectrophotometric methods A and B for the determination of Itopride hydrochloride in bulk and dosage forms.Methods: The proposed methods are based on the formation of chloroform soluble ion-associates in the presence of acidic dyes namely BPB (Method A) and BCP (Method B) exhibiting lmax at 418 and 418 nm respectively.Results: Beer’s law is found to be obeyed in the concentration range of 2.0-10.0 µg/ml and 2.0-10.0 µg/ml. The molar absorptivities are found to be 1.42x104 and 9.61x103L/mol. cm for methods A and B. These methods are successfully applied for the assay of Itopride hydrochloride in pharmaceutical formulations.

scholarly journals Simple Spectrophotometric Methods for Determination of Tenofovir Fumarate and Emtricitabine in Bulk Powder and in Tablets

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Mohammad H. AbdelHay ◽  
Azza A. Gazy ◽  
Rasha A. Shaalan ◽  
Heba K. Ashour
Keyword(s):  
Simultaneous Determination ◽  
Analytical Performance ◽  
Derivative Spectrophotometry ◽  
Spectrophotometric Methods ◽  
First Derivative ◽  
Linearity Range ◽  
Bulk Powder ◽  
First Derivative Spectrophotometry

Two simple and selective methods were developed for the simultaneous determination of tenofovir fumarate (TEN) and emtricitabine (EMT) in combined tablets. The first method involves the application of first derivative spectrophotometry where the first derivative amplitudes were measured at 298.5 nm for determination of EMT in presence of TEN. The second method involves first derivative of ratio spectra spectrophotometry where the amplitudes at 251.5 nm have been used for quantitation of TEN in the presence of EMT. Different variables affecting each method were carefully investigated and optimized. Reliability and analytical performance of the proposed methods, including linearity, range, precision, accuracy, detection, and quantitation limits, were statistically validated. The methods were successfully applied for the determination of EMT and TEN in laboratory-prepared mixtures and in their combined tablets.

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