High Performance Liquid Chromatographic Analysis of Diflubenzuron and Its Formulations: Collaborative Study

1983 ◽  
Vol 66 (2) ◽  
pp. 312-316 ◽  
Author(s):  
Bram Van Rossum ◽  
Albertus Martijn ◽  
Albert A De Reijke ◽  
Jakob Zeeman ◽  
◽  
...  
Keyword(s):  
Chromatographic Analysis ◽  
High Performance ◽  
Collaborative Study ◽  
Internal Standard ◽  
High Performance Liquid Chromatographic ◽  
Water Dispersible ◽  
Liquid Chromatographic Method ◽  
Powder Samples ◽  
Liquid Chromatographic Analysis ◽  
Liquid Chromatographic

Abstract Diflubenzuron 90% pre-concentrate and its 25% water-dispersible powder were analyzed by a high performance liquid chromatographic method. Six samples were extracted with 1,4-dioxane, linuron was added as internal standard, and diflubenzuron was separated on a 25 cm × 4.6 mm column packed with Zorbax BP-C8 with acetonitrile-water-l,4-dioxane (450 + 450 + 100) at 1.3 mL/min and monitored at 254 nm. Results were obtained from 17 laboratories. Within-laboratory repeatability was 0.6% for both the pre-concentrate and the water-dispersible powder samples and the reproducibility was 1.2%. The method has been adopted as a full CIPAC method and was adopted official first action by AOAC.

Liquid-chromatographic analysis for methylphenidate (Ritalin) in serum.

1979 ◽  
Vol 25 (3) ◽  
pp. 401-404 ◽  
Author(s):  
S J Soldin ◽  
Y P Chan ◽  
B M Hill ◽  
J M Swanson
Keyword(s):  
Chromatographic Analysis ◽  
High Performance ◽  
Plasma Sample ◽  
Potassium Phosphate ◽  
Internal Standard ◽  
High Performance Liquid Chromatographic ◽  
Column Temperature ◽  
Liquid Chromatographic Method ◽  
Liquid Chromatographic Analysis ◽  
Liquid Chromatographic

Abstract We describe a "high performance" liquid chromatographic method for quantitating methylphenidate in serum. The internal standard, 4,5-diphenylimidazole, and serum or plasma sample are extracted in chloroform, evaporated, and redissolved in 20 mmol/L potassium phosphate (pH 3.5)/high-purity acetonitrile, 80/20 by vol. A centrifuged aliquot is chromatographed on mu-Bondapak C-18 with the phosphate/acetonitrile solvent as mobile phase, a flow rate of 1.6 mL/min, and a column temperature of 40 degrees C. Absorbances are read at 192 nm. This method reliably measures concentrations greater than 20 micrograms/L and has analytical recoveries of 74%.

Liquid chromatographic analysis of disopyramide and its mono-N-dealkylated metabolite.

1979 ◽  
Vol 25 (3) ◽  
pp. 405-408 ◽  
Author(s):  
J J Lima
Keyword(s):  
Chromatographic Analysis ◽  
Mobile Phase ◽  
High Performance ◽  
Antiarrhythmic Drugs ◽  
Internal Standard ◽  
High Performance Liquid Chromatographic ◽  
Coefficients Of Variation ◽  
Liquid Chromatographic Analysis ◽  
Liquid Chromatographic ◽  
Lower Limits

Abstract We describe a rapid, sensitive, and specific "high performance" liquid chromatographic analysis for disopyramide and its mono-N-dealkylated metabolite in serum, urine, and saliva. We used a mu-Bondapak CN column and an acetate buffer mobile phase containing methanol. Retention times for the two compounds and the internal standard, p-chlorodisopyramide, were 3.4, 4.1, and 6.3 min, respectively. The lower limits of sensitivity for drug and metabolite were 50 and 80 micrograms/L, respectively, with maximum coefficients of variation of 4.6 and 12%, respectively. Currently used antiarrhythmic drugs did not interfere with the analysis of disopyramide, and the pharmacokinetics of the drug, obtained from studies of one subject, agree well with reported values.

scholarly journals The high-performance liquid-chromatographic analysis of ficaprenol and dolichol

1977 ◽  
Vol 165 (2) ◽  
pp. 405-408 ◽  
Author(s):  
R W Keenan ◽  
N Rice ◽  
R Quock
Keyword(s):  
Chromatographic Analysis ◽  
High Performance ◽  
Chromatographic Method ◽  
High Performance Liquid Chromatographic ◽  
Pig Liver ◽  
Liquid Chromatographic Method ◽  
Liquid Chromatographic Analysis ◽  
Liquid Chromatographic ◽  
Derivatives Of

A high-performance liquid-chromatographic method was devised which is capable of resolving the p-nitrobenzoyl derivatives of polyprenols containing 35-110 or more carbon atoms. This procedure was used for the determination of ficaprenol and pig liver dolichol composition and can be applied to mixtures of polyprenols as an analytical or preparative technique.

High Performance Liquid Chromatographic Method for Determination of Temephos in Technical and Formulated Products: Collaborative Study

1982 ◽  
Vol 65 (3) ◽  
pp. 580-583
Author(s):  
James W Miles ◽  
Dwight L Mount
Keyword(s):  
Ethyl Acetate ◽  
High Performance ◽  
Collaborative Study ◽  
Internal Standard ◽  
High Performance Liquid Chromatographic ◽  
Hplc Method ◽  
Water Dispersible ◽  
Coefficients Of Variation ◽  
Liquid Chromatographic

Abstract An HPLC method for the determination of temephos in temephos technical and formulated products has been subjected to an international collaborative study with 14 laboratories participating. Samples were extracted with ethyl acetate and eluted on a silica gel column with ethyl acetate-hexane (1 + 9); p-nitrophenyl p-nitrobenzoate served as the internal standard. Collaborators were furnished samples of technical, 20 and 50% emulsifiable concentrates, 50% water-dispersible powder, and 1% sand granules. The coefficients of variation of the values obtained on the 5 samples were 1.21,2.02,1.26,1.89, and 9.90%, respectively. The method has been adopted official first action.

High Pressure Liquid Chromatographic Analysis of Chlorpyrifos Containing Insecticidal Formulations: Collaborative Study

1981 ◽  
Vol 64 (3) ◽  
pp. 628-634 ◽  
Author(s):  
Norman E Skelly ◽  
David J Jackson ◽  
Phyllis K Anderson ◽  
◽  
J B Audino ◽  
...  
Keyword(s):  
High Pressure ◽  
Chromatographic Analysis ◽  
Collaborative Study ◽  
Internal Standard ◽  
High Pressure Liquid Chromatographic ◽  
Coefficients Of Variation ◽  
Liquid Chromatographic Method ◽  
Liquid Chromatographic Analysis ◽  
Standard Solution ◽  
Liquid Chromatographic

Abstract A high pressure liquid chromatographic method for determining chlorpyrifos was collaboratively studied. Three liquid and 2 solid formulations were analyzed by 12 collaborators. Samples were weighed and diluted with acetonitrile containing the internal standard, 1,4-dibromonaphthalene. Chlorpyriphos is separated on a Zorbax ODS column with acetonitrile- water-acetic acid (82 ± 17.5 ± 0.5) at 2 mL/min and monitored at 300 nm. Clay samples are extracted with the internal standard solution by agitation for 5 min. Coefficients of variation ranged from 1.28 to 2.40%. Results of all 12 collaborators fell within the 5% two-tail limits. The method has been adopted official first action.

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